Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DM75Q34)

Drug Name

NADPH Drug Info

Synonyms

NADP-reduced; reduced Cozymase II; reduced Coenzyme II; b-NADPH; reduced Codehydrase II; Dihydrocodehydrogenase II; dihydronicotinamide adenine dinucleotide-P; GTPL3041; Triphosphopyridine nucleotide reduced; Reduced triphosphopyridine nucleotide; dihydrotriphosphopyridine nucleotide reduced; Nicotinamide-adenine-dinucleotide-phosphorate; b-Nicotinamide-adenine-dinucleotide-phosphorate; Nicotinamide-adenine-dinucleotide-phosphoric acid; beta-Nicotinamide-adenine-dinucleotide-phosphorate

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

Cross-matching ID

PubChem CID: 5884
ChEBI ID: CHEBI:16474
CAS Number: CAS 53-57-6
TTD Drug ID: DM75Q34

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Clinical Trial Drug(s)

Investigative Drug(s)

Download the Complete Related Drug List

Drug(s) Targeting Plasmodium Oxoacyl-[acyl-carrier protein] reductase (Malaria fabG)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Epigallocatechin gallate	DMCGWBJ	Hepatic fibrosis	DB93.0	Phase 3	[3]
Chrysin	DM7V2LG	Discovery agent	N.A.	Investigative	[3]
KAEMPFEROL	DMHEMUB	Discovery agent	N.A.	Investigative	[3]
MORIN	DM2OGZ5	Discovery agent	N.A.	Investigative	[3]
3,7,3',4'-TETRAHYDROXYFLAVONE	DMES906	Discovery agent	N.A.	Investigative	[3]
(-)-CATECHINGALLATE	DMZOGSK	Discovery agent	N.A.	Investigative	[3]
2-Hexadecynoic acid	DMTFIPZ	Discovery agent	N.A.	Investigative	[4]
GALLOCATECHIN GALLATE	DMX2084	Discovery agent	N.A.	Investigative	[3]
ISORHAMNETIN	DMQ4Z6E	Discovery agent	N.A.	Investigative	[3]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

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Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Plasmodium Oxoacyl-[acyl-carrier protein] reductase (Malaria fabG)	TTBE4IR	Q965D6_PLAFA	Cofactor	[2]

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References

1	URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 3041).
2	Functional characterization of beta-ketoacyl-ACP reductase (FabG) from Plasmodium falciparum. Biochem Biophys Res Commun. 2003 Mar 28;303(1):387-92.
3	Inhibition of Plasmodium falciparum fatty acid biosynthesis: evaluation of FabG, FabZ, and FabI as drug targets for flavonoids. J Med Chem. 2006 Jun 1;49(11):3345-53.
4	2-Hexadecynoic acid inhibits plasmodial FAS-II enzymes and arrests erythrocytic and liver stage Plasmodium infections. Bioorg Med Chem. 2010 Nov 1;18(21):7475-85.