Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DM76BGZ)

Drug Name
Dihydroorotate Drug Info
Synonyms
Dihydroorotic acid; hydroorotic acid; 4,5-dihydroorotic acid; DL-Dihydroorotic acid; 155-54-4; 5,6-dihydroorotate; dihydroorotate; 2,6-dioxohexahydropyrimidine-4-carboxylic acid; 2,6-dioxo-1,3-diazinane-4-carboxylic acid; hexahydro-2,6-dioxo-4-Pyrimidinecarboxylic acid; 6202/10/4; CHEBI:30865; L-Hydroorotic acid; 4,5-dihydroorotate; 2,6-Dioxohexahydro-4-pyrimidinecarboxylic acid; Orotic acid, 4,5-dihydro-; L-hydroorotate; R,S-Hydroorotate; 2,6-dioxohexahydro-4-pyrimidincarbons; DL-dihydroortotic acid; AC1Q6GGT; Dihydroorotic Acid
Indication
Disease Entry ICD 11 Status REF
Discovery agent N.A. Investigative [1]
Cross-matching ID
PubChem CID
5461056
ChEBI ID
CHEBI:30867
TTD Drug ID
DM76BGZ

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
Drug Status:
Approved Drug(s)
Clinical Trial Drug(s)
Investigative Drug(s)
Download the Complete Related Drug List
Drug(s) Targeting Plasmodium Dihydroorotate dehydrogenase (Malaria DHOdehase)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Artemisinin DMOY7W3 Malaria 1F40-1F45 Approved [3]
Leflunomide DMR8ONJ Arthritis FA20 Approved [4]
Teriflunomide DMQ2FKJ Hyperlipidaemia 5C80 Approved [5]
Atovaquone DMY4UMW Fungal infection 1F29-1F2F Approved [6]
Avastin+/-Tarceva DMA86FL Non-small-cell lung cancer 2C25.Y Phase 3 [7]
Acetate Ion DMD08RH Discovery agent N.A. Investigative [1]
B-Octylglucoside DMMO75G Discovery agent N.A. Investigative [1]
Orotate DMMB29S Discovery agent N.A. Investigative [8]
Lauryl Dimethylamine-N-Oxide DM3W2OE Discovery agent N.A. Investigative [1]
1,4-Naphthoquinone DMTCMH7 Discovery agent N.A. Investigative [7]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Targeting Plasmodium Dihydroorotase (Malaria dho)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Orotate DMMB29S Discovery agent N.A. Investigative [8]
Lysine Nz-Carboxylic Acid DMW1YK3 Discovery agent N.A. Investigative [1]
5-Fluoro orotate DMLSC10 Discovery agent N.A. Investigative [8]
5-bromo orotate DM0HCG6 Discovery agent N.A. Investigative [8]
N-Carbamoyl-L-Aspartate DMJ13TR Discovery agent N.A. Investigative [1]
5-iodo orotate DMDKFIO Discovery agent N.A. Investigative [8]
5-methyl orotate DMYNFIP Discovery agent N.A. Investigative [8]
⏷ Show the Full List of 7 Drug(s)

Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas
Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Plasmodium Dihydroorotase (Malaria dho) TT09NOX A9CSR1_PLAFA Inhibitor [1]
Plasmodium Dihydroorotate dehydrogenase (Malaria DHOdehase) TT3PQ2Y PYRD_PLAF7 Inhibitor [2]

References

1 How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6.
2 Structure-activity relationships of pyrimidines as dihydroorotate dehydrogenase inhibitors. Biochem Pharmacol. 1988 Oct 15;37(20):3807-16.
3 The fight against drug-resistant malaria: novel plasmodial targets and antimalarial drugs. Curr Med Chem. 2008;15(2):161-71.
4 Identification and characterization of potential new therapeutic targets in inflammatory and autoimmune diseases. Eur J Biochem. 1999 Dec;266(3):1184-91.
5 Expression and characterization of E. coli-produced soluble, functional human dihydroorotate dehydrogenase: a potential target for immunosuppression. J Mol Microbiol Biotechnol. 1999 Aug;1(1):183-8.
6 Inhibitor binding in a class 2 dihydroorotate dehydrogenase causes variations in the membrane-associated N-terminal domain. Protein Sci. 2004 Apr;13(4):1031-42.
7 Kinetics of inhibition of human and rat dihydroorotate dehydrogenase by atovaquone, lawsone derivatives, brequinar sodium and polyporic acid. Chem Biol Interact. 2000 Jan 3;124(1):61-76.
8 Antimalarial activity of orotate analogs that inhibit dihydroorotase and dihydroorotate dehydrogenase. Biochem Pharmacol. 1992 Mar 17;43(6):1295-301.