Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DM7F3RY)

Drug Name
Nitrobenzylthioinosine Drug Info
Synonyms
Oprea1_621177; ZINC13818312; AC1Q1ZDM; AC1L1JO9; SCHEMBL290702; CHEMBL306550; 4-Nitrobenzyl-6-mercaptoinosine; 6-[(4-nitrobenzyl)sulfanyl]-9-pentofuranosyl-9h-purine; CTK8G3023; MolPort-003-721-850; HMS3370O01; AKOS021983903; MCULE-8321028996; TRA0060654; S-(p-NITROBENZYL)-6-THIOINOSINE; NCGC00163303-01; NCGC00015732-02; ST085314; S-(4-Nitrobenzyl)-6-thioinosine (NBTI, NBMPR); SR-01000393938; SR-01000393938-1; 6-[(4-nitrobenzyl)thio]-9- beta-D
Indication
Disease Entry ICD 11 Status REF
Discovery agent N.A. Investigative [1]
Cross-matching ID
PubChem CID
5129
CAS Number
CAS 38048-32-7
TTD Drug ID
DM7F3RY

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
Drug Status:
Approved Drug(s)
Investigative Drug(s)
Download the Complete Related Drug List
Drug(s) Targeting Solute carrier family 29 member 1 (SLC29A1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
LIDOFLAZINE DMV23GL Angina pectoris BA40 Approved [3]
N6-CYCLOPENTYLADENOSINE DMD6AJO Discovery agent N.A. Investigative [4]
Dilazep DMOD5Y0 Discovery agent N.A. Investigative [5]
S6-nitrobenzyl mercaptopurine riboside DMIKJNL Discovery agent N.A. Investigative [6]
[3H]nitrobenzylmercaptopurine ribonucleoside DM5TDFQ Discovery agent N.A. Investigative [7]
KF24345 DMK6SMW Discovery agent N.A. Investigative [8]
NBTGR DMVF420 Discovery agent N.A. Investigative [7]
9-Benzyl-6-(4-nitro-benzylsulfanyl)-9H-purine DMNY5P1 Discovery agent N.A. Investigative [9]
6-(4-Nitro-benzylsulfanyl)-9-phenethyl-9H-purine DMPL5XV Discovery agent N.A. Investigative [9]
⏷ Show the Full List of 9 Drug(s)

Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas
Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Solute carrier family 29 member 1 (SLC29A1) TTLXAKE S29A1_HUMAN Inhibitor [2]

References

1 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 4512).
2 The role of human nucleoside transporters in uptake of 3'-deoxy-3'-fluorothymidine. Mol Pharmacol. 2008 Nov;74(5):1372-80.
3 Synthesis, flow cytometric evaluation, and identification of highly potent dipyridamole analogues as equilibrative nucleoside transporter 1 inhibit... J Med Chem. 2007 Aug 9;50(16):3906-20.
4 Inhibition of nucleoside transport proteins by C8-alkylamine-substituted purines. J Med Chem. 2005 Jan 13;48(1):321-9.
5 Residues Met89 and Ser160 in the human equilibrative nucleoside transporter 1 affect its affinity for adenosine, guanosine, S6-(4-nitrobenzyl)-merc... Mol Pharmacol. 2005 Mar;67(3):837-44.
6 Synthesis and biological evaluation of phloridzin analogs as human concentrative nucleoside transporter 3 (hCNT3) inhibitors. Bioorg Med Chem Lett. 2009 Feb 1;19(3):917-21.
7 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1117).
8 Interaction of the novel adenosine uptake inhibitor 3-[1-(6,7-diethoxy-2-morpholinoquinazolin-4-yl)piperidin-4-yl]-1,6-dimethyl-2,4(1H,3H)-quinazol... J Pharmacol Exp Ther. 2004 Mar;308(3):1083-93.
9 Inhibition of nucleoside transport by new analogues of 4-nitrobenzylthioinosine: replacement of the ribose moiety by substituted benzyl groups. J Med Chem. 2004 Oct 21;47(22):5441-50.