Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DM7QUN0)

• Drug Name: HQK-1001 Drug Info
• Synonyms: Sodium ST-20; Hematological disease therapeutic (oral), HemaQuest

Indication

Disease Entry	ICD 11	Status	REF
Beta thalassemia	3A50.2	Phase 2	[1]

• Cross-matching ID:
  PubChem CID: 53247304
  CAS Number: CAS 3934-02-9
  TTD Drug ID: DM7QUN0

Molecule-Related Drug Atlas

Drug(s) Targeting Hemoglobin (HB)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Voxelotor	DMCS6M5	Sickle-cell disorder	3A51	Approved	[3]
Iron	DMAP8MV	Anemia of prematurity		Approved	[4]
Iron Dextran	DM5OY70	Iron-deficiency anemia	3A00	Approved	[4]
PolyHeme	DMV8EXG	Blood forming organ disorder	JB64.1	Phase 3	[5]
Efaproxyn	DMX7BM4	Lung cancer	2C25.0	Phase 3	[6]
Hemoglobin raffimer	DMMTL7V	Anemia	3A00-3A9Z	Phase 2/3	[7]
GBT021601	DMD3C21	Sickle-cell disorder	3A51	Phase 2/3	[8]
FBS-0701	DMR3952	Iron overload disease	5C64.10	Phase 2	[9]
5-hydroxymethyl-2-furfural	DMPFVJB	Anemia	3A00-3A9Z	Phase 2	[10]
OXY-111A	DMTH75R	Cardiovascular disease	BA00-BE2Z	Phase 1/2	[11]

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Hemoglobin (HB)	TTQO71U	HBA_HUMAN	Inducer	[2]

References

• [1] A phase 2 trial of HQK-1001 in HbE-beta thalassemia demonstrates HbF induction and reduced anemia. Blood. 2014 Mar 20;123(12):1956-7.
• [2] A phase 2 study of HQK-1001, an oral fetal haemoglobin inducer, in beta-thalassaemia intermedia. Br J Haematol. 2014 Feb;164(3):456-8.
• [3] Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health Human Services. 2019
• [4] Efficacy and safety of total dose infusion of low molecular weight iron dextran in the treatment of iron deficiency anemia during pregnancy. J Coll Physicians Surg Pak. 2008 Jul;18(7):424-7.
• [5] Blood substitutes- the polyheme trials. Mcgill J Med. 2008 January; 11(1): 59-65.
• [6] Increased oxygenation of intracranial tumors by efaproxyn (efaproxiral), an allosteric hemoglobin modifier: In vivo EPR oximetry study. Int J Radiat Oncol Biol Phys. 2005 Apr 1;61(5):1503-9.
• [7] Use of hemoglobin raffimer for postoperative life-threatening anemia in a Jehovah's Witness. Can J Anaesth. 2005 Apr;52(4):369-73.
• [8] GBT021601 improves red blood cell health and the pathophysiology of sickle cell disease in a murine model. Br J Haematol. 2023 Jul;202(1):173-183.
• [9] A high-affinity fully human anti-IL-6 mAb, 1339, for the treatment of multiple myeloma. Clin Cancer Res. 2009 Dec 1;15(23):7144-52.
• [10] 5-hydroxymethyl-2-furfural modifies intracellular sickle haemoglobin and inhibits sickling of red blood cells. Br J Haematol. 2005 Feb;128(4):552-61.
• [11] Modulating the oxygen affinity of human fetal haemoglobin with synthetic allosteric modulators. Br J Haematol. 1998 Sep;102(5):1165-71.