Details of the Drug

General Information of Drug (ID: DM5OY70)

Drug Name

Iron Dextran

Synonyms

Chinofer; Dexferrum; Dextrofer; Eisendextran; Fenate; Ferridextran; Ferrodextran; Ferroglucin; Hematran; Icar; Imfergen; Imferon; Imperon; Imposil; Infed; Norferan; Polyfer; Proferdex; Prolongal; Ursoferran; Dextran iron complex; Eisendextran [German]; Fero Gradumet; Ferric dextran; Iron dextran complex; Iron dextran injection; Iron hydrogenated dextran; Ironorm injection; B 75; Dextrofer 75; Ferdex 100; Ferroglukin 75; Myofer 100; A 100 (Pharmaceutical); American Regent Brand of Iron-Dextran Complex; Dextran-Iron Complex; Fe-Dextran; GlaxoSmithKline Brand of Iron-Dextran Complex; Goldline Brand of Iron-Dextran Complex; Hauck Brand of Iron-Dextran Complex; Hawthron Brand of Iron-Dextran Complex; Iro-Jex; Iron-dextran complex; Sanofi Brand of Iron-Dextran Complex; Sulfuric acid, iron salt; Sulphuric acid, iron salt; Vortech Brand of Iron-Dextran Complex; Watson Brand of Iron-Dextran Complex; Sulfuric acid iron salt (1:1); Sulfuric acid, iron salt (1:); Sulfuric acid iron(2+) salt (1:1)

Indication

Disease Entry	ICD 11	Status	REF
Iron-deficiency anemia	3A00	Approved	[1]
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Therapeutic Class

Iron Supplement

Drug Type

Small molecular drug

Structure

3D MOL

2D MOL

#Ro5 Violations (Lipinski):
0

Molecular Weight

153.93

Logarithm of the Partition Coefficient

Not Available

Rotatable Bond Count

0

Hydrogen Bond Donor Count

2

Hydrogen Bond Acceptor Count

4

ADMET Property

Half-life: The concentration or amount of drug in body reduced by one-half in 5 hours [2]

Chemical Identifiers

Formula: FeH2O4S
IUPAC Name: iron;sulfuric acid
Canonical SMILES: OS(=O)(=O)O.[Fe]
InChI: InChI=1S/Fe.H2O4S/c;1-5(2,3)4/h;(H2,1,2,3,4)
InChIKey: MVZXTUSAYBWAAM-UHFFFAOYSA-N

Cross-matching ID

PubChem CID: 105075
CAS Number: 9004-66-4
DrugBank ID: DB00893
TTD ID: D08OKJ

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Hemoglobin (HB)	TTQO71U	HBA_HUMAN	Activator	[3]

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Drug Off-Target (DOT)

DOT Name	DOT ID	UniProt ID	Interaction	REF
Caspase-3 (CASP3)	OTIJRBE7	CASP3_HUMAN	Gene/Protein Processing	[4]
Catalase (CAT)	OTHEBX9R	CATA_HUMAN	Gene/Protein Processing	[4]
Nitric oxide synthase 3 (NOS3)	OTLDT7NR	NOS3_HUMAN	Post-Translational Modifications	[4]
Putative hydrolase DDAH2 (DDAH2)	OT8Q40G2	DDAH2_HUMAN	Gene/Protein Processing	[4]

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Molecular Interaction Atlas (MIA)

MIA Detail

Jump to Detail Molecular Interaction Atlas of This Drug

Drug-Drug Interaction (DDI) Information of This Drug

Coadministration of a Drug Treating the Same Disease as Iron Dextran

DDI Drug Name	DDI Drug ID	Severity	Mechanism	Disease	REF
Iron	DMAP8MV	Moderate	Altered absorption of Iron Dextran caused by Iron.	Iron deficiency anaemia [3A00]	[5]
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References

1	FDA Approved Drug Products from FDA Official Website. 2009. Application Number: (NDA) 010787.
2	Trend Analysis of a Database of Intravenous Pharmacokinetic Parameters in Humans for 1352 Drug Compounds
3	Efficacy and safety of total dose infusion of low molecular weight iron dextran in the treatment of iron deficiency anemia during pregnancy. J Coll Physicians Surg Pak. 2008 Jul;18(7):424-7.
4	Tetramethylpyrazine alleviates iron overload damage in vascular endothelium via upregulating DDAHII expression. Toxicol In Vitro. 2020 Jun;65:104817. doi: 10.1016/j.tiv.2020.104817. Epub 2020 Mar 2.
5	Product Information. Feraheme (ferumoxytol). Alza Pharmaceuticals, Mountain View, CA.