Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DM7T1CR)

Drug Name
LY3016859 Drug Info
Synonyms TGF-alpha.epiregulin mAb
Indication
Disease Entry ICD 11 Status REF
Chronic kidney disease GB61 Phase 1/2 [1]
Cross-matching ID
TTD Drug ID
DM7T1CR

Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas
Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Epiregulin (EREG) TTYSB89 EREG_HUMAN Modulator [2]
Transforming growth factor alpha (TGFA) TTTLQFR TGFA_HUMAN Modulator [2]

References

1 ClinicalTrials.gov (NCT01774981) Study of LY3016859 in Participants With Diabetic Nephropathy. U.S. National Institutes of Health.
2 Generation and activity of a humanized monoclonal antibody that selectively neutralizes the epidermal growth factor receptor ligands transforming growth factor-alpha and epiregulin. J Pharmacol Exp Ther. 2014 May;349(2):330-43.