Details of the Drug

General Information of Drug (ID: DM7T1CR)

Drug Name

LY3016859

Synonyms

TGF-alpha.epiregulin mAb

Indication

Disease Entry	ICD 11	Status	REF
Chronic kidney disease	GB61	Phase 1/2	[1]
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Cross-matching ID

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Epiregulin (EREG)	TTYSB89	EREG_HUMAN	Modulator	[2]
Transforming growth factor alpha (TGFA)	TTTLQFR	TGFA_HUMAN	Modulator	[2]

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Molecular Interaction Atlas (MIA)

Jump to Detail Molecular Interaction Atlas of This Drug

References

1	ClinicalTrials.gov (NCT01774981) Study of LY3016859 in Participants With Diabetic Nephropathy. U.S. National Institutes of Health.
2	Generation and activity of a humanized monoclonal antibody that selectively neutralizes the epidermal growth factor receptor ligands transforming growth factor-alpha and epiregulin. J Pharmacol Exp Ther. 2014 May;349(2):330-43.