Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DM804UR)

Drug Name
Hyoscyamine Drug Info
Synonyms
L-Hyoscyamine; hyoscyamine; 101-31-5; (-)-Hyoscyamine; Daturine; Duboisine; (-)-Atropine; L-Tropine tropate; (S)-Atropine; (S)-(-)-Hyoscyamine; Hyoscyamine (L); UNII-PX44XO846X; Tropine, (-)-tropate; Levbid; PX44XO846X; Levsinex SR; CHEBI:17486; Hyoscyamine, l-; [3(S)-endo]-alpha-(hydroxymethyl)benzeneacetic acid 8-methyl-8-azabicyclo[321]oct-3-yl ester; (2S)-(1R,5S)-8-Methyl-8-azabicyclo[321]octan-3-yl 3-hydroxy-2-phenylpropanoate; (1R,5S)-8-METHYL-8-AZABICYCLO[321]OCT-3-YL (2R)-3-HYDROXY-2-PHENYLPROPANOATE; Hyocyamine
Indication
Disease Entry ICD 11 Status REF
Dysuria MF50.7 Approved [1]
Gastrointestinal disease DE2Z Approved [2]
Peptic ulcer DA61 Approved [3]
Sick sinus syndrome 2, autosomal dominant Approved [1]
Vernal keratoconjunctivitis Approved [1]
Therapeutic Class
Antiarrhythmic Agents
Cross-matching ID
PubChem CID
154417
ChEBI ID
CHEBI:17486
CAS Number
CAS 101-31-5
TTD Drug ID
DM804UR

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
Drug Status:
Approved Drug(s)
Download the Complete Related Drug List
Drug(s) Targeting Muscarinic acetylcholine receptor M5 (CHRM5)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Promazine DMZAL7W Acute intermittent hepatic porphyria 5C58.11 Approved [5]
ACECLIDINE DMOLNCZ Glaucoma/ocular hypertension 9C61 Approved [6]
Pilocarpine DMV9ADG Glaucoma/ocular hypertension 9C61 Approved [7]
Anisodine DMNOSWU Central and peripheral nervous disease 8A04-8E7Z Approved [8]
Atropine DMEN6X7 Organophosphate poisoning NE6Z Approved [9]
Propiverine DMUWBIJ Urinary incontinence MF50.2 Approved [10]
Umeclidinium DM4E8O9 Chronic obstructive pulmonary disease CA22 Approved [11]
Cimetropium bromide DMZHPNE Gastric motility disorder DA21 Approved [12]
Butylscopolamine DMZKXB7 Dysmenorrhea GA34.3 Approved [13]
Trospium DMX6RTG Overactive bladder GC50.0 Approved [14]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas
Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Muscarinic acetylcholine receptor M5 (CHRM5) TTH18TF ACM5_HUMAN Antagonist [4]

References

1 A standard database for drug repositioning. Sci Data. 2017 Mar 14;4:170029.
2 Emerging drugs for irritable bowel syndrome. Expert Opin Emerg Drugs. 2006 May;11(2):293-313.
3 Clinical significance of M1 receptor antagonists. Pharmacology. 1988;37 Suppl 1:54-63.
4 Reconstitution of the purified porcine atrial muscarinic acetylcholine receptor with purified porcine atrial inhibitory guanine nucleotide binding protein. Biochemistry. 1987 Dec 15;26(25):8175-82.
5 Muscarinic cholinergic and histamine H1 receptor binding of phenothiazine drug metabolites. Life Sci. 1988;43(5):405-12.
6 Design, synthesis, and neurochemical evaluation of 5-(3-alkyl-1,2,4- oxadiazol-5-yl)-1,4,5,6-tetrahydropyrimidines as M1 muscarinic receptor agonists. J Med Chem. 1993 Apr 2;36(7):842-7.
7 Retinoic acid prevents virus-induced airway hyperreactivity and M2 receptor dysfunction via anti-inflammatory and antiviral effects. Am J Physiol Lung Cell Mol Physiol. 2009 Aug;297(2):L340-6.
8 Medicinal plants in therapy. Bull World Health Organ. 1985;63(6):965-81.
9 Additive protective effects of donepezil and nicotine against salsolinol-induced cytotoxicity in SH-SY5Y cells. Neurotox Res. 2009 Oct;16(3):194-204.
10 Affinity profiles of various muscarinic antagonists for cloned human muscarinic acetylcholine receptor (mAChR) subtypes and mAChRs in rat heart and submandibular gland. Life Sci. 1999;64(25):2351-8.
11 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7354).
12 Natural products as sources of new drugs over the last 25 years. J Nat Prod. 2007 Mar;70(3):461-77.
13 Comparison of pharmacological effects of L- and DL-n-butyl-scopolamine in rat uterus. Yao Xue Xue Bao. 1994;29(1):24-7.
14 Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34.