General Information of Drug (ID: DMZAL7W)

Drug Name
Promazine
Synonyms
Ampazine; Berophen; Esparin; Liranol; Prazin; Prazine; Promazin; Promazina; Promazinum; Promwill; Propazinum; Protactyl; Romtiazin; Sinophenin; Tomil; Verophen; Combelen [veterinary]; Promazina [Italian]; A 145; RP 3276; WY 1094; Combelen [veterinary] (TN); Neo-Hibernex; Promazina [INN-Spanish]; Promazine (INN); Promazine [INN:BAN]; Promazinum [INN-Latin]; Sparine (TN); Wy-1094; N-(3-Dimethylaminopropyl)phenothiazine; N-Dimethylamino-1-methylethyl thiodiphenylamine; Dimethyl(3-phenothiazin-10-ylpropyl)amine; N,N-dimethyl-3-phenothiazin-10-ylpropan-1-amine; N,N-dimethyl-3-(10H-phenothiazin-10-yl)propan-1-amine; 10-(3-(Dimethylamino)propyl)phenothiazine; 10-[3-(Dimethylamino)propyl]phenothiazine; 10H-Phenothiazine-10-propanamine, N,N-dimethyl-(9CI); 10H-Phenothiazine-10-propanamine, N,N-dimethyl-, monohydrochloride
Indication
Disease Entry ICD 11 Status REF
Acute intermittent hepatic porphyria 5C58.11 Approved [1]
Allergic rhinitis CA08.0 Approved [1]
Angioedema 4A00.15 Approved [1]
Disruptive behavior disorder N.A. Approved [1]
Nausea MD90 Approved [1]
Psychomotor agitation MB23.M Approved [2]
Psychotic disorder 6A20-6A25 Approved [1]
Urticaria EB00-EB05 Approved [1]
Vomiting MD90 Approved [1]
Pruritus EC90 Investigative [1]
⏷ Show the Full List of Indication(s)
Therapeutic Class
Antipsychotic Agents
Drug Type
Small molecular drug
Structure
3D MOL 2D MOL
#Ro5 Violations (Lipinski): 0 Molecular Weight (mw) 284.4
Logarithm of the Partition Coefficient (xlogp) 4.5
Rotatable Bond Count (rotbonds) 4
Hydrogen Bond Donor Count (hbonddonor) 0
Hydrogen Bond Acceptor Count (hbondacc) 3
ADMET Property
BDDCS Class
Biopharmaceutics Drug Disposition Classification System (BDDCS) Class 1: high solubility and high permeability [3]
Clearance
The drug present in the plasma can be removed from the body at the rate of 14 mL/min/kg [4]
Elimination
2% of drug is excreted from urine in the unchanged form [3]
Half-life
The concentration or amount of drug in body reduced by one-half in 7.9 hours [4]
Metabolism
The drug is metabolized via the hepatic []
MRTD
The Maximum Recommended Therapeutic Dose (MRTD) of drug that ensured maximising efficacy and moderate side effect is 50.2258 micromolar/kg/day [5]
Unbound Fraction
The unbound fraction of drug in plasma is 0.11% [4]
Vd
Fluid volume that would be required to contain the amount of drug present in the body at the same concentration as in the plasma 8.1 L/kg [4]
Water Solubility
The ability of drug to dissolve in water is measured as 333.33 mg/mL [3]
Chemical Identifiers
Formula
C17H20N2S
IUPAC Name
N,N-dimethyl-3-phenothiazin-10-ylpropan-1-amine
Canonical SMILES
CN(C)CCCN1C2=CC=CC=C2SC3=CC=CC=C31
InChI
InChI=1S/C17H20N2S/c1-18(2)12-7-13-19-14-8-3-5-10-16(14)20-17-11-6-4-9-15(17)19/h3-6,8-11H,7,12-13H2,1-2H3
InChIKey
ZGUGWUXLJSTTMA-UHFFFAOYSA-N
Cross-matching ID
PubChem CID
4926
ChEBI ID
CHEBI:8459
CAS Number
58-40-2
DrugBank ID
DB00420
TTD ID
D00NAX
VARIDT ID
DR00887
INTEDE ID
DR1351
Repurposed Drugs (RPD) Click to Jump to the Detailed RPD Information of This Drug

Molecular Interaction Atlas of This Drug


Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Muscarinic acetylcholine receptor M5 (CHRM5) TTH18TF ACM5_HUMAN Binder [6]

Drug-Metabolizing Enzyme (DME)
DME Name DME ID UniProt ID MOA REF
Cytochrome P450 3A4 (CYP3A4) DE4LYSA CP3A4_HUMAN Substrate [7]
Cytochrome P450 2C9 (CYP2C9) DE5IED8 CP2C9_HUMAN Substrate [8]
Mephenytoin 4-hydroxylase (CYP2C19) DEGTFWK CP2CJ_HUMAN Substrate [7]
Cytochrome P450 1A2 (CYP1A2) DEJGDUW CP1A2_HUMAN Substrate [7]

Drug Off-Target (DOT)
DOT Name DOT ID UniProt ID Interaction REF
Cholinesterase (BCHE) OTOH3WQ9 CHLE_HUMAN Gene/Protein Processing [9]
Corticoliberin (CRH) OT2MOC4T CRF_HUMAN Gene/Protein Processing [10]
Potassium voltage-gated channel subfamily H member 2 (KCNH2) OTZX881H KCNH2_HUMAN Gene/Protein Processing [11]
Molecular Interaction Atlas (MIA) Jump to Detail Molecular Interaction Atlas of This Drug

Drug-Drug Interaction (DDI) Information of This Drug

Coadministration of a Drug Treating the Disease Different from Promazine (Comorbidity)
DDI Drug Name DDI Drug ID Severity Mechanism Comorbidity REF
Ivosidenib DM8S6T7 Major Increased risk of prolong QT interval by the combination of Promazine and Ivosidenib. Acute myeloid leukaemia [2A60] [12]
Midostaurin DMI6E0R Moderate Increased risk of prolong QT interval by the combination of Promazine and Midostaurin. Acute myeloid leukaemia [2A60] [13]
Daunorubicin DMQUSBT Moderate Increased risk of prolong QT interval by the combination of Promazine and Daunorubicin. Acute myeloid leukaemia [2A60] [13]
Arn-509 DMT81LZ Moderate Increased risk of prolong QT interval by the combination of Promazine and Arn-509. Acute myeloid leukaemia [2A60] [14]
Gilteritinib DMTI0ZO Moderate Increased risk of prolong QT interval by the combination of Promazine and Gilteritinib. Acute myeloid leukaemia [2A60] [15]
Oliceridine DM6MDCF Major Additive CNS depression effects by the combination of Promazine and Oliceridine. Acute pain [MG31] [16]
Scopolamine DMOM8AL Moderate Additive anticholinergic effects by the combination of Promazine and Scopolamine. Addictive disorder [6C50-6C5Z] [17]
Mepyramine DMB4SFH Moderate Additive anticholinergic effects by the combination of Promazine and Mepyramine. Allergic/hypersensitivity disorder [4A80-4A8Z] [18]
Memantine DMD9WSC Moderate Additive anticholinergic effects by the combination of Promazine and Memantine. Alzheimer disease [8A20] [17]
Galantamine DMEO794 Moderate Antagonize the effect of Promazine when combined with Galantamine. Alzheimer disease [8A20] [19]
Rivastigmine DMG629M Moderate Antagonize the effect of Promazine when combined with Rivastigmine. Alzheimer disease [8A20] [19]
Donepezil DMIYG7Z Moderate Antagonize the effect of Promazine when combined with Donepezil. Alzheimer disease [8A20] [19]
Metronidazole DMTIVEN Minor Increased risk of prolong QT interval by the combination of Promazine and Metronidazole. Amoebiasis [1A36] [20]
Isosorbide dinitrate DMBI4JG Moderate Additive hypotensive effects by the combination of Promazine and Isosorbide dinitrate. Anal fissure/fistula [DB50] [21]
Ivabradine DM0L594 Major Increased risk of ventricular arrhythmias by the combination of Promazine and Ivabradine. Angina pectoris [BA40] [14]
Dronedarone DMA8FS5 Major Increased risk of prolong QT interval by the combination of Promazine and Dronedarone. Angina pectoris [BA40] [13]
Amyl nitrite DMJKO05 Moderate Additive hypotensive effects by the combination of Promazine and Amyl nitrite. Angina pectoris [BA40] [21]
Nifedipine DMSVOZT Moderate Additive hypotensive effects by the combination of Promazine and Nifedipine. Angina pectoris [BA40] [21]
Bedaquiline DM3906J Major Increased risk of prolong QT interval by the combination of Promazine and Bedaquiline. Antimicrobial drug resistance [MG50-MG52] [22]
Hydroxyzine DMF8Y74 Moderate Additive anticholinergic effects by the combination of Promazine and Hydroxyzine. Anxiety disorder [6B00-6B0Z] [17]
Cilostazol DMZMSCT Moderate Increased risk of prolong QT interval by the combination of Promazine and Cilostazol. Arterial occlusive disease [BD40] [13]
Posaconazole DMUL5EW Moderate Increased risk of prolong QT interval by the combination of Promazine and Posaconazole. Aspergillosis [1F20] [13]
Levalbuterol DM5YBO1 Moderate Increased risk of ventricular arrhythmias by the combination of Promazine and Levalbuterol. Asthma [CA23] [23]
Terbutaline DMD4381 Moderate Increased risk of ventricular arrhythmias by the combination of Promazine and Terbutaline. Asthma [CA23] [24]
Pirbuterol DMI5678 Moderate Increased risk of prolong QT interval by the combination of Promazine and Pirbuterol. Asthma [CA23] [23]
Salbutamol DMN9CWF Moderate Increased risk of ventricular arrhythmias by the combination of Promazine and Salbutamol. Asthma [CA23] [23]
Formoterol DMSOURV Moderate Increased risk of ventricular arrhythmias by the combination of Promazine and Formoterol. Asthma [CA23] [24]
Lisdexamfetamine DM6W8V5 Moderate Antagonize the effect of Promazine when combined with Lisdexamfetamine. Attention deficit hyperactivity disorder [6A05] [25]
Methylphenidate DM7SJD6 Moderate Antagonize the effect of Promazine when combined with Methylphenidate. Attention deficit hyperactivity disorder [6A05] [25]
Ofloxacin DM0VQN3 Moderate Increased risk of prolong QT interval by the combination of Promazine and Ofloxacin. Bacterial infection [1A00-1C4Z] [26]
Ciprofloxacin XR DM2NLS9 Moderate Increased risk of prolong QT interval by the combination of Promazine and Ciprofloxacin XR. Bacterial infection [1A00-1C4Z] [13]
Clarithromycin DM4M1SG Moderate Increased risk of prolong QT interval by the combination of Promazine and Clarithromycin. Bacterial infection [1A00-1C4Z] [13]
Sulfamethoxazole DMB08GE Minor Increased risk of prolong QT interval by the combination of Promazine and Sulfamethoxazole. Bacterial infection [1A00-1C4Z] [13]
Linezolid DMGFPU2 Moderate Additive hypotensive effects by the combination of Promazine and Linezolid. Bacterial infection [1A00-1C4Z] [27]
Gemifloxacin DMHT34O Moderate Increased risk of prolong QT interval by the combination of Promazine and Gemifloxacin. Bacterial infection [1A00-1C4Z] [26]
Norfloxacin DMIZ6W2 Moderate Increased risk of prolong QT interval by the combination of Promazine and Norfloxacin. Bacterial infection [1A00-1C4Z] [20]
Telithromycin DMZ4P3A Moderate Increased risk of prolong QT interval by the combination of Promazine and Telithromycin. Bacterial infection [1A00-1C4Z] [13]
Retigabine DMGNYIH Moderate Increased risk of prolong QT interval by the combination of Promazine and Retigabine. Behcet disease [4A62] [28]
Cariprazine DMJYDVK Moderate Additive anticholinergic effects by the combination of Promazine and Cariprazine. Bipolar disorder [6A60] [17]
Loperamide DMOJZQ9 Moderate Additive antimotility effects by the combination of Promazine and Loperamide. Bowel habit change [ME05] [29]
Eribulin DM1DX4Q Moderate Increased risk of prolong QT interval by the combination of Promazine and Eribulin. Breast cancer [2C60-2C6Y] [13]
Tamoxifen DMLB0EZ Moderate Increased risk of prolong QT interval by the combination of Promazine and Tamoxifen. Breast cancer [2C60-2C6Y] [13]
Toremifene DMQYUWG Major Increased risk of prolong QT interval by the combination of Promazine and Toremifene. Breast cancer [2C60-2C6Y] [13]
Sotalol DML60TN Major Increased risk of prolong QT interval by the combination of Promazine and Sotalol. Cardiac arrhythmia [BC9Z] [13]
Acetylcholine DMDF79Z Moderate Antagonize the effect of Promazine when combined with Acetylcholine. Cataract [9B10] [30]
PF-04449913 DMSB068 Moderate Increased risk of prolong QT interval by the combination of Promazine and PF-04449913. Chronic myelomonocytic leukaemia [2A40] [31]
Umeclidinium DM4E8O9 Moderate Additive anticholinergic effects by the combination of Promazine and Umeclidinium. Chronic obstructive pulmonary disease [CA22] [32]
Olodaterol DM62B78 Moderate Increased risk of ventricular arrhythmias by the combination of Promazine and Olodaterol. Chronic obstructive pulmonary disease [CA22] [24]
Vilanterol DMF5EK1 Moderate Increased risk of ventricular arrhythmias by the combination of Promazine and Vilanterol. Chronic obstructive pulmonary disease [CA22] [23]
Tiotropium DMFDC0Q Moderate Additive anticholinergic effects by the combination of Promazine and Tiotropium. Chronic obstructive pulmonary disease [CA22] [32]
Salmeterol DMIEU69 Moderate Increased risk of prolong QT interval by the combination of Promazine and Salmeterol. Chronic obstructive pulmonary disease [CA22] [24]
Revefenacin DMMP5SI Moderate Additive anticholinergic effects by the combination of Promazine and Revefenacin. Chronic obstructive pulmonary disease [CA22] [32]
Indacaterol DMQJHR7 Moderate Increased risk of ventricular arrhythmias by the combination of Promazine and Indacaterol. Chronic obstructive pulmonary disease [CA22] [24]
Dihydrocodeine DMB0FWL Major Additive CNS depression effects by the combination of Promazine and Dihydrocodeine. Chronic pain [MG30] [16]
Oxaliplatin DMQNWRD Moderate Increased risk of prolong QT interval by the combination of Promazine and Oxaliplatin. Colorectal cancer [2B91] [13]
Isoproterenol DMK7MEY Moderate Increased risk of ventricular arrhythmias by the combination of Promazine and Isoproterenol. Conduction disorder [BC63] [23]
Olopatadine DMKMWQG Moderate Additive CNS depression effects by the combination of Promazine and Olopatadine. Conjunctiva disorder [9A60] [33]
Halothane DM80OZ5 Moderate Increased risk of prolong QT interval by the combination of Promazine and Halothane. Corneal disease [9A76-9A78] [13]
Propofol DMB4OLE Moderate Increased risk of prolong QT interval by the combination of Promazine and Propofol. Corneal disease [9A76-9A78] [34]
Sevoflurane DMC9O43 Moderate Increased risk of prolong QT interval by the combination of Promazine and Sevoflurane. Corneal disease [9A76-9A78] [13]
Alfentanil DMVO0UB Major Additive CNS depression effects by the combination of Promazine and Alfentanil. Corneal disease [9A76-9A78] [35]
Remifentanil DMZTXCH Major Additive CNS depression effects by the combination of Promazine and Remifentanil. Corneal disease [9A76-9A78] [35]
Clofazimine DMEBOFW Moderate Increased risk of prolong QT interval by the combination of Promazine and Clofazimine. Crohn disease [DD70] [36]
Mifepristone DMGZQEF Major Increased risk of prolong QT interval by the combination of Promazine and Mifepristone. Cushing syndrome [5A70] [13]
Pasireotide DMHM7JS Major Increased risk of prolong QT interval by the combination of Promazine and Pasireotide. Cushing syndrome [5A70] [13]
Sertraline DM0FB1J Moderate Increased risk of prolong QT interval by the combination of Promazine and Sertraline. Depression [6A70-6A7Z] [13]
Trimipramine DM1SC8M Moderate Increased plasma concentrations of Promazine and Trimipramine due to competitive inhibition of the same metabolic pathway. Depression [6A70-6A7Z] [37]
Imipramine DM2NUH3 Moderate Increased plasma concentrations of Promazine and Imipramine due to competitive inhibition of the same metabolic pathway. Depression [6A70-6A7Z] [37]
Fluoxetine DM3PD2C Moderate Decreased metabolism of Promazine caused by Fluoxetine mediated inhibition of CYP450 enzyme. Depression [6A70-6A7Z] [38]
Nortriptyline DM4KDYJ Moderate Increased plasma concentrations of Promazine and Nortriptyline due to competitive inhibition of the same metabolic pathway. Depression [6A70-6A7Z] [37]
Paroxetine DM5PVQE Moderate Decreased metabolism of Promazine caused by Paroxetine mediated inhibition of CYP450 enzyme. Depression [6A70-6A7Z] [39]
Selegiline DM6034S Moderate Additive hypotensive effects by the combination of Promazine and Selegiline. Depression [6A70-6A7Z] [27]
Duloxetine DM9BI7M Moderate Decreased metabolism of Promazine caused by Duloxetine mediated inhibition of CYP450 enzyme. Depression [6A70-6A7Z] [40]
Isocarboxazid DMAF1NB Moderate Additive hypotensive effects by the combination of Promazine and Isocarboxazid. Depression [6A70-6A7Z] [27]
Escitalopram DMFK9HG Major Increased risk of prolong QT interval by the combination of Promazine and Escitalopram. Depression [6A70-6A7Z] [13]
OPC-34712 DMHG57U Moderate Additive anticholinergic effects by the combination of Promazine and OPC-34712. Depression [6A70-6A7Z] [17]
Phenelzine DMHIDUE Moderate Additive hypotensive effects by the combination of Promazine and Phenelzine. Depression [6A70-6A7Z] [27]
Clomipramine DMINRKW Moderate Increased plasma concentrations of Promazine and Clomipramine due to competitive inhibition of the same metabolic pathway. Depression [6A70-6A7Z] [37]
Trazodone DMK1GBJ Moderate Increased risk of prolong QT interval by the combination of Promazine and Trazodone. Depression [6A70-6A7Z] [41]
Amoxapine DMKITQE Moderate Increased plasma concentrations of Promazine and Amoxapine due to competitive inhibition of the same metabolic pathway. Depression [6A70-6A7Z] [37]
Doxepin DMPI98T Moderate Increased plasma concentrations of Promazine and Doxepin due to competitive inhibition of the same metabolic pathway. Depression [6A70-6A7Z] [42]
Maprotiline DMPWB7T Moderate Additive anticholinergic effects by the combination of Promazine and Maprotiline. Depression [6A70-6A7Z] [17]
Esketamine DMVU687 Moderate Additive CNS depression effects by the combination of Promazine and Esketamine. Depression [6A70-6A7Z] [20]
Nitroglycerin DMQ2491 Moderate Additive hypotensive effects by the combination of Promazine and Nitroglycerin. Diabetic foot ulcer [BD54] [21]
Hyoscyamine DM804UR Moderate Additive anticholinergic effects by the combination of Promazine and Hyoscyamine. Digestive system disease [DE2Z] [17]
Mepenzolate DM8YU2F Moderate Additive anticholinergic effects by the combination of Promazine and Mepenzolate. Digestive system disease [DE2Z] [18]
Oxybutynine DMJPBAX Moderate Additive anticholinergic effects by the combination of Promazine and Oxybutynine. Discovery agent [N.A.] [17]
Tetrabenazine DMYWQ0O Major Additive antidopaminergic effects by the combination of Promazine and Tetrabenazine. Dissociative neurological symptom disorder [6B60] [43]
Meclizine DMS7T13 Moderate Additive anticholinergic effects by the combination of Promazine and Meclizine. Dizziness and giddiness [MB48] [17]
Deutetrabenazine DMUPFLI Major Increased risk of prolong QT interval by the combination of Promazine and Deutetrabenazine. Dystonic disorder [8A02] [44]
Ingrezza DMVPLNC Moderate Increased risk of prolong QT interval by the combination of Promazine and Ingrezza. Dystonic disorder [8A02] [45]
Zonisamide DM0DTF7 Major Increased risk of hyperpyrexia by the combination of Promazine and Zonisamide. Epilepsy/seizure [8A61-8A6Z] [46]
Stiripentol DMMSDOY Moderate Decreased metabolism of Promazine caused by Stiripentol mediated inhibition of CYP450 enzyme. Epilepsy/seizure [8A61-8A6Z] [47]
Guanabenz DM5QWEL Moderate Additive hypotensive effects by the combination of Promazine and Guanabenz. Essential hypertension [BA00] [48]
Ethacrynic acid DM60QMR Moderate Additive hypotensive effects by the combination of Promazine and Ethacrynic acid. Essential hypertension [BA00] [48]
Phenoxybenzamine DM8KSQH Moderate Additive hypotensive effects by the combination of Promazine and Phenoxybenzamine. Essential hypertension [BA00] [21]
Nicardipine DMCDYW7 Moderate Additive hypotensive effects by the combination of Promazine and Nicardipine. Essential hypertension [BA00] [21]
Mecamylamine DMGQFYB Moderate Additive hypotensive effects by the combination of Promazine and Mecamylamine. Essential hypertension [BA00] [21]
Nadolol DMW6GVL Moderate Additive hypotensive effects by the combination of Promazine and Nadolol. Essential hypertension [BA00] [21]
Solifenacin DMG592Q Moderate Increased risk of prolong QT interval by the combination of Promazine and Solifenacin. Functional bladder disorder [GC50] [13]
Tolterodine DMSHPW8 Moderate Additive anticholinergic effects by the combination of Promazine and Tolterodine. Functional bladder disorder [GC50] [17]
Darifenacin DMWXLYZ Moderate Decreased metabolism of Promazine caused by Darifenacin mediated inhibition of CYP450 enzyme. Functional bladder disorder [GC50] [49]
Pentamidine DMHZJCG Moderate Increased risk of prolong QT interval by the combination of Promazine and Pentamidine. Fungal infection [1F29-1F2F] [13]
Terbinafine DMI6HUW Moderate Decreased metabolism of Promazine caused by Terbinafine mediated inhibition of CYP450 enzyme. Fungal infection [1F29-1F2F] [50]
Amphotericin B DMTAJQE Moderate Increased risk of ventricular arrhythmias by the combination of Promazine and Amphotericin B. Fungal infection [1F29-1F2F] [20]
Phentolamine DMXYJOB Moderate Additive hypotensive effects by the combination of Promazine and Phentolamine. Gangrene [MC85] [21]
Propantheline DM2EN6G Moderate Additive anticholinergic effects by the combination of Promazine and Propantheline. Gastric ulcer [DA60] [17]
Sunitinib DMCBJSR Moderate Increased risk of prolong QT interval by the combination of Promazine and Sunitinib. Gastrointestinal stromal tumour [2B5B] [13]
Acetazolamide DM1AF5U Moderate Increased risk of ventricular arrhythmias by the combination of Promazine and Acetazolamide. Glaucoma [9C61] [20]
Brimonidine DMQLT4N Moderate Additive CNS depression effects by the combination of Promazine and Brimonidine. Glaucoma [9C61] [51]
Pilocarpine DMV9ADG Moderate Antagonize the effect of Promazine when combined with Pilocarpine. Glaucoma [9C61] [30]
Spironolactone DM2AQ5N Moderate Additive hypotensive effects by the combination of Promazine and Spironolactone. Heart failure [BD10-BD1Z] [21]
Prazosin DMCD9YG Moderate Additive hypotensive effects by the combination of Promazine and Prazosin. Heart failure [BD10-BD1Z] [21]
Eplerenone DMF0NQR Moderate Additive hypotensive effects by the combination of Promazine and Eplerenone. Heart failure [BD10-BD1Z] [21]
Carvedilol DMHTEAO Moderate Additive hypotensive effects by the combination of Promazine and Carvedilol. Heart failure [BD10-BD1Z] [21]
Chlorothiazide DMLHESP Moderate Increased risk of ventricular arrhythmias by the combination of Promazine and Chlorothiazide. Heart failure [BD10-BD1Z] [20]
Furosemide DMMQ8ZG Moderate Increased risk of ventricular arrhythmias by the combination of Promazine and Furosemide. Heart failure [BD10-BD1Z] [20]
Amiloride DMRTSGP Moderate Additive hypotensive effects by the combination of Promazine and Amiloride. Heart failure [BD10-BD1Z] [21]
Bumetanide DMRV7H0 Moderate Increased risk of ventricular arrhythmias by the combination of Promazine and Bumetanide. Heart failure [BD10-BD1Z] [20]
Hydroflumethiazide DMVPUQI Moderate Increased risk of ventricular arrhythmias by the combination of Promazine and Hydroflumethiazide. Heart failure [BD10-BD1Z] [20]
Procarbazine DMIK367 Moderate Additive CNS depression effects by the combination of Promazine and Procarbazine. Hodgkin lymphoma [2B30] [27]
Efavirenz DMC0GSJ Major Increased risk of prolong QT interval by the combination of Promazine and Efavirenz. Human immunodeficiency virus disease [1C60-1C62] [52]
Saquinavir DMG814N Major Increased risk of prolong QT interval by the combination of Promazine and Saquinavir. Human immunodeficiency virus disease [1C60-1C62] [53]
Rilpivirine DMJ0QOW Moderate Increased risk of prolong QT interval by the combination of Promazine and Rilpivirine. Human immunodeficiency virus disease [1C60-1C62] [13]
Ritonavir DMU764S Moderate Decreased metabolism of Promazine caused by Ritonavir mediated inhibition of CYP450 enzyme. Human immunodeficiency virus disease [1C60-1C62] [54]
Isosorbide mononitrate DMYLMU0 Moderate Additive hypotensive effects by the combination of Promazine and Isosorbide mononitrate. Hydrocephalus [8D64] [21]
Cinacalcet DMCX0K3 Moderate Decreased metabolism of Promazine caused by Cinacalcet mediated inhibition of CYP450 enzyme. Hyper-parathyroidism [5A51] [20]
Eprosartan DM07K2I Moderate Additive hypotensive effects by the combination of Promazine and Eprosartan. Hypertension [BA00-BA04] [21]
Acebutolol DM0TI4U Moderate Additive hypotensive effects by the combination of Promazine and Acebutolol. Hypertension [BA00-BA04] [21]
Moexipril DM26E4B Moderate Additive hypotensive effects by the combination of Promazine and Moexipril. Hypertension [BA00-BA04] [21]
Bisoprolol DM3UZ95 Moderate Additive hypotensive effects by the combination of Promazine and Bisoprolol. Hypertension [BA00-BA04] [21]
Captopril DM458UM Moderate Additive hypotensive effects by the combination of Promazine and Captopril. Hypertension [BA00-BA04] [21]
Trandolapril DM4L6EU Moderate Additive hypotensive effects by the combination of Promazine and Trandolapril. Hypertension [BA00-BA04] [21]
Methyldopa DM5I621 Moderate Additive hypotensive effects by the combination of Promazine and Methyldopa. Hypertension [BA00-BA04] [21]
Clonidine DM6RZ9Q Moderate Additive hypotensive effects by the combination of Promazine and Clonidine. Hypertension [BA00-BA04] [21]
Losartan DM72JXH Moderate Additive hypotensive effects by the combination of Promazine and Losartan. Hypertension [BA00-BA04] [21]
Nebivolol DM7F1PA Moderate Additive hypotensive effects by the combination of Promazine and Nebivolol. Hypertension [BA00-BA04] [21]
Levamlodipine DM92S6N Moderate Additive hypotensive effects by the combination of Promazine and Levamlodipine. Hypertension [BA00-BA04] [21]
Fosinopril DM9NJ52 Moderate Additive hypotensive effects by the combination of Promazine and Fosinopril. Hypertension [BA00-BA04] [21]
Doxazosin DM9PLRH Moderate Additive hypotensive effects by the combination of Promazine and Doxazosin. Hypertension [BA00-BA04] [21]
Verapamil DMA7PEW Moderate Additive hypotensive effects by the combination of Promazine and Verapamil. Hypertension [BA00-BA04] [21]
TAK-491 DMCF6SX Moderate Additive hypotensive effects by the combination of Promazine and TAK-491. Hypertension [BA00-BA04] [21]
Fenoldopam DMFAOKP Moderate Additive hypotensive effects by the combination of Promazine and Fenoldopam. Hypertension [BA00-BA04] [21]
Indapamide DMGN1PW Moderate Increased risk of ventricular arrhythmias by the combination of Promazine and Indapamide. Hypertension [BA00-BA04] [20]
Benazepril DMH1M9B Moderate Additive hypotensive effects by the combination of Promazine and Benazepril. Hypertension [BA00-BA04] [21]
Labetalol DMK8U72 Moderate Additive hypotensive effects by the combination of Promazine and Labetalol. Hypertension [BA00-BA04] [21]
Diazoxide DML1538 Moderate Additive hypotensive effects by the combination of Promazine and Diazoxide. Hypertension [BA00-BA04] [21]
Enalapril DMNFUZR Moderate Additive hypotensive effects by the combination of Promazine and Enalapril. Hypertension [BA00-BA04] [21]
Perindopril DMOPZDT Moderate Additive hypotensive effects by the combination of Promazine and Perindopril. Hypertension [BA00-BA04] [21]
Felodipine DMOSW35 Moderate Additive hypotensive effects by the combination of Promazine and Felodipine. Hypertension [BA00-BA04] [21]
Quinapril DMR8H31 Moderate Additive hypotensive effects by the combination of Promazine and Quinapril. Hypertension [BA00-BA04] [21]
Telmisartan DMS3GX2 Moderate Additive hypotensive effects by the combination of Promazine and Telmisartan. Hypertension [BA00-BA04] [21]
Irbesartan DMTP1DC Moderate Additive hypotensive effects by the combination of Promazine and Irbesartan. Hypertension [BA00-BA04] [21]
Hydralazine DMU8JGH Moderate Additive hypotensive effects by the combination of Promazine and Hydralazine. Hypertension [BA00-BA04] [21]
Lisinopril DMUOK4C Moderate Additive hypotensive effects by the combination of Promazine and Lisinopril. Hypertension [BA00-BA04] [21]
Hydrochlorothiazide DMUSZHD Moderate Increased risk of ventricular arrhythmias by the combination of Promazine and Hydrochlorothiazide. Hypertension [BA00-BA04] [20]
Fludrocortisone DMUDIR8 Moderate Increased risk of ventricular arrhythmias by the combination of Promazine and Fludrocortisone. Hypo-osmolality/hyponatraemia [5C72] [20]
ITI-007 DMUQ1DO Moderate Additive anticholinergic effects by the combination of Promazine and ITI-007. Insomnia [7A00-7A0Z] [17]
Polyethylene glycol DM4I1JP Moderate Increased risk of lowers seizure threshold by the combination of Promazine and Polyethylene glycol. Irritable bowel syndrome [DD91] [13]
Clidinium DMUMQZ0 Moderate Additive anticholinergic effects by the combination of Promazine and Clidinium. Irritable bowel syndrome [DD91] [17]
Dicyclomine DMZSDGX Moderate Additive anticholinergic effects by the combination of Promazine and Dicyclomine. Irritable bowel syndrome [DD91] [17]
Physostigmine DM2N0TO Moderate Antagonize the effect of Promazine when combined with Physostigmine. Lips/oral mucosa miscellaneous disorder [DA02] [19]
Crizotinib DM4F29C Major Increased risk of prolong QT interval by the combination of Promazine and Crizotinib. Lung cancer [2C25] [55]
Porfimer Sodium DM7ZWNY Moderate Increased risk of photosensitivity reactions by the combination of Promazine and Porfimer Sodium. Lung cancer [2C25] [56]
Ceritinib DMB920Z Major Increased risk of prolong QT interval by the combination of Promazine and Ceritinib. Lung cancer [2C25] [13]
Osimertinib DMRJLAT Major Increased risk of prolong QT interval by the combination of Promazine and Osimertinib. Lung cancer [2C25] [57]
Selpercatinib DMZR15V Major Increased risk of prolong QT interval by the combination of Promazine and Selpercatinib. Lung cancer [2C25] [58]
Lumefantrine DM29GAD Major Increased risk of prolong QT interval by the combination of Promazine and Lumefantrine. Malaria [1F40-1F45] [20]
Chloroquine DMSI5CB Major Increased risk of prolong QT interval by the combination of Promazine and Chloroquine. Malaria [1F40-1F45] [59]
Hydroxychloroquine DMSIVND Major Increased risk of prolong QT interval by the combination of Promazine and Hydroxychloroquine. Malaria [1F40-1F45] [59]
Quinine DMSWYF5 Moderate Increased risk of prolong QT interval by the combination of Promazine and Quinine. Malaria [1F40-1F45] [13]
Primaquine DMWQ16I Moderate Increased risk of prolong QT interval by the combination of Promazine and Primaquine. Malaria [1F40-1F45] [13]
Inotuzumab ozogamicin DMAC130 Moderate Increased risk of prolong QT interval by the combination of Promazine and Inotuzumab ozogamicin. Malignant haematopoietic neoplasm [2B33] [14]
Arsenic trioxide DM61TA4 Major Increased risk of ventricular arrhythmias by the combination of Promazine and Arsenic trioxide. Mature B-cell lymphoma [2A85] [60]
Vemurafenib DM62UG5 Major Increased risk of prolong QT interval by the combination of Promazine and Vemurafenib. Melanoma [2C30] [13]
Allopregnanolone DMNLHAC Moderate Additive CNS depression effects by the combination of Promazine and Allopregnanolone. Mental/behavioural/neurodevelopmental disorder [6E20-6E8Z] [61]
Propranolol DM79NTF Moderate Additive hypotensive effects by the combination of Promazine and Propranolol. Migraine [8A80] [21]
Lasmiditan DMXLVDT Moderate Additive CNS depression effects by the combination of Promazine and Lasmiditan. Migraine [8A80] [62]
Panobinostat DM58WKG Major Increased risk of prolong QT interval by the combination of Promazine and Panobinostat. Multiple myeloma [2A83] [63]
Thalidomide DM70BU5 Moderate Additive CNS depression effects by the combination of Promazine and Thalidomide. Multiple myeloma [2A83] [14]
Siponimod DM2R86O Major Increased risk of ventricular arrhythmias by the combination of Promazine and Siponimod. Multiple sclerosis [8A40] [20]
Fingolimod DM5JVAN Major Increased risk of ventricular arrhythmias by the combination of Promazine and Fingolimod. Multiple sclerosis [8A40] [64]
Ozanimod DMT6AM2 Major Increased risk of ventricular arrhythmias by the combination of Promazine and Ozanimod. Multiple sclerosis [8A40] [14]
Methoxsalen DME8FZ9 Moderate Increased risk of photosensitivity reactions by the combination of Promazine and Methoxsalen. Mycosis fungoides [2B01] [20]
Romidepsin DMT5GNL Moderate Increased risk of prolong QT interval by the combination of Promazine and Romidepsin. Mycosis fungoides [2B01] [28]
Nilotinib DM7HXWT Major Increased risk of prolong QT interval by the combination of Promazine and Nilotinib. Myeloproliferative neoplasm [2A20] [13]
Imatinib DM7RJXL Moderate Decreased metabolism of Promazine caused by Imatinib mediated inhibition of CYP450 enzyme. Myeloproliferative neoplasm [2A20] [65]
Dasatinib DMJV2EK Moderate Increased risk of prolong QT interval by the combination of Promazine and Dasatinib. Myeloproliferative neoplasm [2A20] [66]
Dextroamphetamine DMMIHVP Moderate Antagonize the effect of Promazine when combined with Dextroamphetamine. Narcolepsy [7A20] [25]
Droperidol DM0DXA8 Major Increased risk of prolong QT interval by the combination of Promazine and Droperidol. Nausea/vomiting [MD90] [13]
Dimenhydrinate DM264B3 Moderate Additive anticholinergic effects by the combination of Promazine and Dimenhydrinate. Nausea/vomiting [MD90] [17]
Prochlorperazine DM53SRA Moderate Additive anticholinergic effects by the combination of Promazine and Prochlorperazine. Nausea/vomiting [MD90] [17]
Promethazine DM6I5GR Moderate Additive anticholinergic effects by the combination of Promazine and Promethazine. Nausea/vomiting [MD90] [17]
Metoclopramide DMFA5MY Major Additive antidopaminergic effects by the combination of Promazine and Metoclopramide. Nausea/vomiting [MD90] [67]
Granisetron DMIUW25 Moderate Increased risk of prolong QT interval by the combination of Promazine and Granisetron. Nausea/vomiting [MD90] [13]
Ondansetron DMOTQ1I Moderate Increased risk of prolong QT interval by the combination of Promazine and Ondansetron. Nausea/vomiting [MD90] [13]
Bupropion DM5PCS7 Major Decreased metabolism of Promazine caused by Bupropion mediated inhibition of CYP450 enzyme. Nicotine use disorder [6C4A] [13]
Entrectinib DMMPTLH Moderate Increased risk of prolong QT interval by the combination of Promazine and Entrectinib. Non-small cell lung cancer [2C25] [14]
Phendimetrazine DM6TS1N Moderate Antagonize the effect of Promazine when combined with Phendimetrazine. Obesity [5B80-5B81] [25]
Amfepramone DM9YSNQ Moderate Antagonize the effect of Promazine when combined with Amfepramone. Obesity [5B80-5B81] [25]
Lorcaserin DMG6OYJ Moderate Decreased metabolism of Promazine caused by Lorcaserin mediated inhibition of CYP450 enzyme. Obesity [5B80-5B81] [68]
Benzphetamine DMIJATC Moderate Antagonize the effect of Promazine when combined with Benzphetamine. Obesity [5B80-5B81] [25]
Metolazone DMB39LO Moderate Increased risk of ventricular arrhythmias by the combination of Promazine and Metolazone. Oedema [MG29] [20]
Polythiazide DMCH80F Moderate Increased risk of ventricular arrhythmias by the combination of Promazine and Polythiazide. Oedema [MG29] [20]
Lofexidine DM1WXA6 Moderate Increased risk of prolong QT interval by the combination of Promazine and Lofexidine. Opioid use disorder [6C43] [13]
Apraclonidine DMO4PVE Moderate Additive CNS depression effects by the combination of Promazine and Apraclonidine. Optic nerve disorder [9C40] [51]
Rucaparib DM9PVX8 Moderate Increased risk of prolong QT interval by the combination of Promazine and Rucaparib. Ovarian cancer [2C73] [13]
Pentazocine DM1XBHS Major Additive CNS depression effects by the combination of Promazine and Pentazocine. Pain [MG30-MG3Z] [35]
Dextropropoxyphene DM23HCX Major Additive CNS depression effects by the combination of Promazine and Dextropropoxyphene. Pain [MG30-MG3Z] [69]
Butorphanol DM5KYPJ Major Additive CNS depression effects by the combination of Promazine and Butorphanol. Pain [MG30-MG3Z] [35]
Oxymorphone DM65AGJ Major Additive CNS depression effects by the combination of Promazine and Oxymorphone. Pain [MG30-MG3Z] [35]
Levorphanol DMGS80V Major Additive CNS depression effects by the combination of Promazine and Levorphanol. Pain [MG30-MG3Z] [35]
Flavoxate DMKV4NL Moderate Additive anticholinergic effects by the combination of Promazine and Flavoxate. Pain [MG30-MG3Z] [17]
Nalbuphine DMOSQGU Major Additive CNS depression effects by the combination of Promazine and Nalbuphine. Pain [MG30-MG3Z] [35]
Methamphetamine DMPM4SK Moderate Antagonize the effect of Promazine when combined with Methamphetamine. Pain [MG30-MG3Z] [70]
Buprenorphine DMPRI8G Major Additive CNS depression effects by the combination of Promazine and Buprenorphine. Pain [MG30-MG3Z] [71]
Hydrocodone DMQ2JO5 Major Additive CNS depression effects by the combination of Promazine and Hydrocodone. Pain [MG30-MG3Z] [35]
Meperidine DMX4GND Major Additive CNS depression effects by the combination of Promazine and Meperidine. Pain [MG30-MG3Z] [35]
Oxycodone DMXLKHV Major Additive CNS depression effects by the combination of Promazine and Oxycodone. Pain [MG30-MG3Z] [35]
Triclabendazole DMPWGBR Moderate Increased risk of prolong QT interval by the combination of Promazine and Triclabendazole. Parasitic worm infestation [1F90] [28]
Pergolide DM14MAE Moderate Antagonize the effect of Promazine when combined with Pergolide. Parkinsonism [8A00] [72]
Opicapone DM1BKA6 Moderate Antagonize the effect of Promazine when combined with Opicapone. Parkinsonism [8A00] [73]
Rasagiline DM3WKQ4 Moderate Additive hypotensive effects by the combination of Promazine and Rasagiline. Parkinsonism [8A00] [27]
Biperiden DME78OA Moderate Antagonize the effect of Promazine when combined with Biperiden. Parkinsonism [8A00] [74]
Entacapone DMLBVKQ Moderate Antagonize the effect of Promazine when combined with Entacapone. Parkinsonism [8A00] [72]
Levodopa DMN3E57 Moderate Additive hypotensive effects by the combination of Promazine and Levodopa. Parkinsonism [8A00] [72]
Pimavanserin DMR7IVC Moderate Increased risk of prolong QT interval by the combination of Promazine and Pimavanserin. Parkinsonism [8A00] [75]
Bromocriptine DMVE3TK Moderate Antagonize the effect of Promazine when combined with Bromocriptine. Parkinsonism [8A00] [72]
Apomorphine DMX38HQ Moderate Antagonize the effect of Promazine when combined with Apomorphine. Parkinsonism [8A00] [76]
Methylscopolamine DM5VWOB Moderate Additive anticholinergic effects by the combination of Promazine and Methylscopolamine. Peptic ulcer [DA61] [17]
Famotidine DMRL3AB Moderate Increased risk of prolong QT interval by the combination of Promazine and Famotidine. Peptic ulcer [DA61] [20]
Macimorelin DMQYJIR Major Increased risk of prolong QT interval by the combination of Promazine and Macimorelin. Pituitary gland disorder [5A60-5A61] [77]
Lefamulin DME6G97 Major Increased risk of prolong QT interval by the combination of Promazine and Lefamulin. Pneumonia [CA40] [12]
Hydrocortisone DMGEMB7 Moderate Increased risk of ventricular arrhythmias by the combination of Promazine and Hydrocortisone. Postoperative inflammation [1A00-CA43] [20]
Degarelix DM3O8QY Moderate Increased risk of prolong QT interval by the combination of Promazine and Degarelix. Prostate cancer [2C82] [14]
ABIRATERONE DM8V75C Moderate Decreased metabolism of Promazine caused by ABIRATERONE mediated inhibition of CYP450 enzyme. Prostate cancer [2C82] [78]
Nilutamide DMFN07X Moderate Increased risk of prolong QT interval by the combination of Promazine and Nilutamide. Prostate cancer [2C82] [14]
Enzalutamide DMGL19D Moderate Increased risk of prolong QT interval by the combination of Promazine and Enzalutamide. Prostate cancer [2C82] [14]
Flutamide DMK0O7U Moderate Increased risk of prolong QT interval by the combination of Promazine and Flutamide. Prostate cancer [2C82] [14]
Bicalutamide DMZMSPF Moderate Increased risk of prolong QT interval by the combination of Promazine and Bicalutamide. Prostate cancer [2C82] [14]
Terazosin DM3JCVS Moderate Additive hypotensive effects by the combination of Promazine and Terazosin. Prostate hyperplasia [GA90] [21]
Tamsulosin DM5QF9V Moderate Additive hypotensive effects by the combination of Promazine and Tamsulosin. Prostate hyperplasia [GA90] [21]
Silodosin DMJSBT6 Moderate Additive hypotensive effects by the combination of Promazine and Silodosin. Prostate hyperplasia [GA90] [21]
Verteporfin DMIY6DB Moderate Increased risk of photosensitivity reactions by the combination of Promazine and Verteporfin. Psoriasis [EA90] [14]
Fluphenazine DMIT8LX Moderate Additive anticholinergic effects by the combination of Promazine and Fluphenazine. Psychotic disorder [6A20-6A25] [17]
Gatifloxacin DMSL679 Major Increased risk of prolong QT interval by the combination of Promazine and Gatifloxacin. Respiratory infection [CA07-CA4Z] [79]
Neupro DMHEAB1 Moderate Antagonize the effect of Promazine when combined with Neupro. Restless legs syndrome [7A80] [72]
Celecoxib DM6LOQU Moderate Decreased metabolism of Promazine caused by Celecoxib mediated inhibition of CYP450 enzyme. Rheumatoid arthritis [FA20] [80]
Cyproheptadine DM92AH3 Moderate Additive anticholinergic effects by the combination of Promazine and Cyproheptadine. Rheumatoid arthritis [FA20] [17]
Quetiapine DM1N62C Moderate Increased risk of prolong QT interval by the combination of Promazine and Quetiapine. Schizophrenia [6A20] [13]
Mesoridazine DM2ZGAN Major Increased risk of prolong QT interval by the combination of Promazine and Mesoridazine. Schizophrenia [6A20] [20]
Thioridazine DM35M8J Major Increased risk of prolong QT interval by the combination of Promazine and Thioridazine. Schizophrenia [6A20] [81]
Aripiprazole DM3NUMH Moderate Additive anticholinergic effects by the combination of Promazine and Aripiprazole. Schizophrenia [6A20] [17]
Iloperidone DM6AUFY Major Increased risk of prolong QT interval by the combination of Promazine and Iloperidone. Schizophrenia [6A20] [13]
Paliperidone DM7NPJS Moderate Increased risk of prolong QT interval by the combination of Promazine and Paliperidone. Schizophrenia [6A20] [13]
Haloperidol DM96SE0 Major Increased risk of prolong QT interval by the combination of Promazine and Haloperidol. Schizophrenia [6A20] [13]
Molindone DMAH70G Moderate Additive anticholinergic effects by the combination of Promazine and Molindone. Schizophrenia [6A20] [17]
Chlorpromazine DMBGZI3 Moderate Additive anticholinergic effects by the combination of Promazine and Chlorpromazine. Schizophrenia [6A20] [17]
Thiothixene DMDINC4 Moderate Additive anticholinergic effects by the combination of Promazine and Thiothixene. Schizophrenia [6A20] [17]
Trifluoperazine DMKBYWI Moderate Additive anticholinergic effects by the combination of Promazine and Trifluoperazine. Schizophrenia [6A20] [17]
Risperidone DMN6DXL Moderate Additive anticholinergic effects by the combination of Promazine and Risperidone. Schizophrenia [6A20] [17]
Amisulpride DMSJVAM Major Increased risk of prolong QT interval by the combination of Promazine and Amisulpride. Schizophrenia [6A20] [82]
Asenapine DMSQZE2 Moderate Increased risk of prolong QT interval by the combination of Promazine and Asenapine. Schizophrenia [6A20] [13]
Pimozide DMW83TP Major Increased risk of prolong QT interval by the combination of Promazine and Pimozide. Schizophrenia [6A20] [14]
Fentanyl DM8WAHT Major Additive CNS depression effects by the combination of Promazine and Fentanyl. Sensation disturbance [MB40] [35]
Vardenafil DMTBGW8 Moderate Increased risk of prolong QT interval by the combination of Promazine and Vardenafil. Sexual dysfunction [HA00-HA01] [13]
LEE011 DMMX75K Major Increased risk of prolong QT interval by the combination of Promazine and LEE011. Solid tumour/cancer [2A00-2F9Z] [13]
Epirubicin DMPDW6T Moderate Increased risk of prolong QT interval by the combination of Promazine and Epirubicin. Solid tumour/cancer [2A00-2F9Z] [13]
Cisplatin DMRHGI9 Moderate Increased risk of ventricular arrhythmias by the combination of Promazine and Cisplatin. Solid tumour/cancer [2A00-2F9Z] [20]
Vandetanib DMRICNP Major Increased risk of prolong QT interval by the combination of Promazine and Vandetanib. Solid tumour/cancer [2A00-2F9Z] [13]
Doxorubicin DMVP5YE Moderate Increased risk of prolong QT interval by the combination of Promazine and Doxorubicin. Solid tumour/cancer [2A00-2F9Z] [13]
Pitolisant DM8RFNJ Moderate Increased risk of prolong QT interval by the combination of Promazine and Pitolisant. Somnolence [MG42] [13]
Telavancin DM58VQX Moderate Increased risk of prolong QT interval by the combination of Promazine and Telavancin. Staphylococcal/streptococcal disease [1B5Y] [13]
Adenosine DMM2NSK Moderate Increased risk of ventricular arrhythmias by the combination of Promazine and Adenosine. Supraventricular tachyarrhythmia [BC81] [13]
Lenvatinib DMB1IU4 Moderate Increased risk of prolong QT interval by the combination of Promazine and Lenvatinib. Thyroid cancer [2D10] [13]
Cabozantinib DMIYDT4 Major Increased risk of prolong QT interval by the combination of Promazine and Cabozantinib. Thyroid cancer [2D10] [14]
Tizanidine DMR2IQ4 Moderate Additive CNS depression effects by the combination of Promazine and Tizanidine. Tonus and reflex abnormality [MB47] [83]
Tacrolimus DMZ7XNQ Moderate Increased risk of prolong QT interval by the combination of Promazine and Tacrolimus. Transplant rejection [NE84] [13]
Atropine DMEN6X7 Moderate Additive anticholinergic effects by the combination of Promazine and Atropine. Unspecific substance harmful effect [NE6Z] [17]
Triprolidine DM7SWIA Moderate Additive anticholinergic effects by the combination of Promazine and Triprolidine. Vasomotor/allergic rhinitis [CA08] [17]
Carbinoxamine DMCT31R Moderate Additive anticholinergic effects by the combination of Promazine and Carbinoxamine. Vasomotor/allergic rhinitis [CA08] [17]
Brompheniramine DMFOVSD Moderate Additive anticholinergic effects by the combination of Promazine and Brompheniramine. Vasomotor/allergic rhinitis [CA08] [17]
Acrivastine DMTIGA0 Moderate Additive anticholinergic effects by the combination of Promazine and Acrivastine. Vasomotor/allergic rhinitis [CA08] [18]
Procainamide DMNMXR8 Major Increased risk of prolong QT interval by the combination of Promazine and Procainamide. Ventricular tachyarrhythmia [BC71] [13]
Propafenone DMPIBJK Moderate Increased risk of prolong QT interval by the combination of Promazine and Propafenone. Ventricular tachyarrhythmia [BC71] [13]
Flecainide DMSQDLE Moderate Increased risk of prolong QT interval by the combination of Promazine and Flecainide. Ventricular tachyarrhythmia [BC71] [13]
⏷ Show the Full List of 286 DDI Information of This Drug

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64 Product Information. Gilenya (fingolimod). Novartis Pharmaceuticals, East Hanover, NJ.
65 Product Information. Gleevec (imatinib mesylate). Novartis Pharmaceuticals, East Hanover, NJ.
66 Product Information. Sprycel (dasatinib). Bristol-Myers Squibb, Princeton, NJ.
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77 Product Information. Macrilen (macimorelin). Aeterna Zentaris, Charleston, SC.
78 Product Information. Zytiga (abiraterone). Centocor Inc, Malvern, PA.
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82 Product Information. Barhemsys (amisulpride). Acacia Pharma, Inc, Indianapolis, IN.
83 Product Information. Zanaflex (tizanidine). Acorda Therapeutics, Hawthorne, NY.