Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DM8ONCL)

Drug Name
Carbamide derivative 25 Drug Info
Synonyms PMID29053063-Compound-12b
Cross-matching ID
TTD Drug ID
DM8ONCL

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
Drug Status:
Approved Drug(s)
Clinical Trial Drug(s)
Patented Agent(s)
Download the Complete Related Drug List
Drug(s) Targeting Fatty acid amide hydrolase (FAAH)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Propofol DMB4OLE Anaesthesia 9A78.6 Approved [2]
Thiopental DMGP8AX Anaesthesia 9A78.6 Approved [3]
JNJ-42165279 DM72GZO Anxiety disorder 6B00-6B0Z Phase 2 [4]
SSR411298 DMGTB2Q Major depressive disorder 6A70.3 Phase 2 [5]
IW-6118 DMP42W1 Inflammation 1A00-CA43.1 Phase 2 [6]
PF-04457845 DMPRYU1 Liver disease DB90-BD99 Phase 2 [7]
IPI-940 DMEIM5G Pain MG30-MG3Z Phase 1 [8]
PMID29053063-Compound-11d DMDRK68 N. A. N. A. Patented [1]
Piperazine carbamic compound 1 DMZSYU4 N. A. N. A. Patented [1]
Piperazine carbamic compound 2 DMMQ0ZO N. A. N. A. Patented [1]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Targeting Monoglyceride lipase (MAGL)
Drug Name Drug ID Indication ICD 11 Highest Status REF
ABX-1431 DM9SYVJ Neuropathic pain 8E43.0 Phase 1 [9]
PMID29053063-Compound-11d DMDRK68 N. A. N. A. Patented [1]
Piperazine carbamic compound 1 DMZSYU4 N. A. N. A. Patented [1]
Piperazine carbamic compound 2 DMMQ0ZO N. A. N. A. Patented [1]
Pyrazole derivative 82 DMETCI3 N. A. N. A. Patented [1]
Pyrazole derivative 81 DMWT437 N. A. N. A. Patented [1]
PMID29053063-Compound-15 DM07U5R N. A. N. A. Patented [1]
Pyrazole derivative 80 DMQ3TGM N. A. N. A. Patented [1]
Carbamide derivative 24 DMD6Y73 N. A. N. A. Patented [1]
Piperazine carbamic compound 4 DMKZUO4 N. A. N. A. Patented [1]
⏷ Show the Full List of 10 Drug(s)

Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas
Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Fatty acid amide hydrolase (FAAH) TTDP1UC NOUNIPROTAC Inhibitor [1]
Monoglyceride lipase (MAGL) TTZ963I MGLL_HUMAN Inhibitor [1]

References

1 A patent review of Monoacylglycerol Lipase (MAGL) inhibitors (2013-2017).Expert Opin Ther Pat. 2017 Dec;27(12):1341-1351.
2 Glutamate- and GABA-based CNS therapeutics. Curr Opin Pharmacol. 2006 Feb;6(1):7-17.
3 The general anesthetic propofol increases brain N-arachidonylethanolamine (anandamide) content and inhibits fatty acid amide hydrolase. Br J Pharmacol. 2003 Jul;139(5):1005-13.
4 Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
5 Pharma & Vaccines. Product Development Pipeline. April 29 2009.
6 The Discovery and Development of Inhibitors of Fatty Acid Amide Hydrolase (FAAH). Bioorg Med Chem Lett. 2011 August 15; 21(16): 4674-4685.
7 Discovery of PF-04457845: A Highly Potent, Orally Bioavailable, and Selective Urea FAAH Inhibitor. ACS Med Chem Lett. 2011 Feb 10;2(2):91-96.
8 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1400).
9 Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)