Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DM8Q54I)

Drug Name

PBIT Drug Info

Synonyms

2514-30-9; PBIT; 2-(4-methylphenyl)-1,2-benzisothiazol-3(2H)-one; 2-(4-methylphenyl)-1,2-benzothiazol-3-one; MLS000583746; 2-(p-Tolyl)benzo[d]isothiazol-3(2H)-one; 2-(p-tolyl)-1,2-benzothiazol-3-one; SMR000200989; 2-(4-methylphenyl)-1,2-benzothiazol-3(2H)-one; 1,2-Benzisothiazol-3(2H)-one, 2-(4-methylphenyl)-; 2-(4-methylphenyl)-2,3-dihydro-1,2-benzothiazol-3-one; ChemDiv3_007090; AC1LIP69; cid_935415; SCHEMBL2443755; GTPL7026; CHEMBL1336959; CTK0J4356; BDBM34737; AOB6896; DTXSID10359056; MolPort-002-285-696; HMS2576N21

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

Cross-matching ID

PubChem CID: 935415
CAS Number: CAS 2514-30-9
TTD Drug ID: DM8Q54I

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Patented Agent(s)

Investigative Drug(s)

Download the Complete Related Drug List

Drug(s) Targeting Lysine-specific demethylase 5A (KDM5A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
6EP	DMN082G	N. A.	N. A.	Patented	[2]
BDBM50158803	DMTWI1H	N. A.	N. A.	Patented	[3]
US10022354, Example 151	DMVCWXD	N. A.	N. A.	Patented	[4]
US9714230, 12	DMEB59T	N. A.	N. A.	Patented	[2]
BDBM50158791	DMU07MO	N. A.	N. A.	Patented	[5]
US10040779, Example 4	DMWDGCH	N. A.	N. A.	Patented	[6]
US9611221, Example 9	DMSD354	N. A.	N. A.	Patented	[7]
US9714230, 46	DMPZS16	N. A.	N. A.	Patented	[8]
BDBM50158794	DMWJZU9	N. A.	N. A.	Patented	[6]
BDBM50158703	DMS7ZLK	N. A.	N. A.	Patented	[2]
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⏷ Show the Full List of 10 Drug(s)

Drug(s) Targeting Lysine-specific demethylase 5C (KDM5C)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
IOX2	DMQ0X7I	Discovery agent	N.A.	Investigative	[9]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Lysine-specific demethylase 5A (KDM5A)	TTIG67W	KDM5A_HUMAN	Inhibitor	[1]
Lysine-specific demethylase 5B (KDM5B)	TTCLI75	KDM5B_HUMAN	Inhibitor	[1]
Lysine-specific demethylase 5C (KDM5C)	TT94UCF	KDM5C_HUMAN	Inhibitor	[1]

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References

1	Identification of small molecule inhibitors of Jumonji AT-rich interactive domain 1B (JARID1B) histone demethylase by a sensitive high throughput screen. J Biol Chem. 2013 Mar 29;288(13):9408-17.
2	Histone demethylase inhibitors. US9714230.
3	Histone demethylase inhibitors. US9617242.
4	IRE-1 inhibitors
5	Histone demethylase inhibitors. US9725441.
6	Histone demethylase inhibitors. US10040779.
7	Histone demethylase inhibitors. US9611221.
8	Histone demethylase inhibitors. US9604961.
9	Selective small molecule probes for the hypoxia inducible factor (HIF) prolyl hydroxylases. ACS Chem Biol. 2013 Jul 19;8(7):1488-96.