General Information of Drug (ID: DM8QZNC)

Drug Name
PMID27998201-Compound-12 Drug Info
Indication
Disease Entry ICD 11 Status REF
Bone cancer 2B5Z Patented [1]
Cancer related pain MG30 Patented [1]
Cross-matching ID
TTD Drug ID
DM8QZNC

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
Drug Status:
Clinical Trial Drug(s)
Patented Agent(s)
Preclinical Drug(s)
Investigative Drug(s)
Drug(s) Targeting Cathepsin K (CTSK)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Odanacatib DM1EO3G Osteoporosis FB83.0 Phase 3 [2]
SAR-114137 DMZ1XR5 Pain MG30-MG3Z Phase 1 [3]
VEL-0230 DMDSC63 Rheumatoid arthritis FA20 Phase 1 [4]
PMID27998201-Compound-5 DMVZ0ND Chronic obstructive pulmonary disease CA22 Patented [1]
PMID27998201-Compound-9 DM1JOZN Rheumatoid arthritis FA20 Patented [1]
PMID25399719-Compound-17 DMRXKJZ N. A. N. A. Patented [5]
PMID27998201-Compound-15 DMOB8LU Pain MG30-MG3Z Patented [1]
Oxotetrahydro-2-H-furo[3.2-b]pyrrol-4(5-H)-yl derivative 1 DM1SH5R Pain MG30-MG3Z Patented [1]
PMID27998201-Compound-8 DMZK0SY N. A. N. A. Patented [1]
PMID27998201-Compound-10 DMVXTIL Osteoporosis FB83.0 Patented [1]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Targeting Cathepsin L (CTSL)
Drug Name Drug ID Indication ICD 11 Highest Status REF
KGP94 DM2NZ6K Coagulation defect 3B10.0 Clinical trial [6]
PMID27998201-Compound-5 DMVZ0ND Chronic obstructive pulmonary disease CA22 Patented [1]
PMID27998201-Compound-9 DM1JOZN Rheumatoid arthritis FA20 Patented [1]
PMID25399719-Compound-17 DMRXKJZ N. A. N. A. Patented [5]
PMID27998201-Compound-17 DMAZVHJ Hair loss ED70 Patented [1]
Phenylalanine derivative 1 DMVYP8K Glioma 2A00.0 Patented [1]
PMID27998201-Compound-7 DMU4QYR Abdominal aortic aneurysm BD50.4 Patented [1]
PMID27998201-Compound-6 DM0LGTY N. A. N. A. Patented [1]
PMID27998201-Compound-1 DM5QH4C Coronavirus infection 1D92 Patented [1]
PMID27998201-Compound-19 DM67RMX Solid tumour/cancer 2A00-2F9Z Patented [1]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Targeting Cathepsin B (CTSB)
Drug Name Drug ID Indication ICD 11 Highest Status REF
PMID27998201-Compound-5 DMVZ0ND Chronic obstructive pulmonary disease CA22 Patented [1]
PMID27998201-Compound-9 DM1JOZN Rheumatoid arthritis FA20 Patented [1]
PMID27998201-Compound-17 DMAZVHJ Hair loss ED70 Patented [1]
PMID27998201-Compound-11 DMTV5NU Metastatic cancer 2D50-2E2Z Patented [1]
PMID27998201-Compound-2 DMMAE3C Alzheimer disease 8A20 Patented [1]
PMID27998201-Compound-22 DMS9QA7 Alzheimer disease 8A20 Patented [1]
PMID27998201-Compound-13 DMZHIM8 Hepatic fibrosis DB93.0 Patented [1]
Dimethoxybenzylidene-2-thio-imidazole-4-one derivative 1 DMZ4B3W Cerebral ischemia 8B11 Patented [1]
PMID27998201-Compound-24 DM25BNZ Glioma 2A00.0 Patented [1]
L-006235-1 DMMEH12 Osteoarthritis FA00-FA05 Preclinical [7]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Targeting Cathepsin S (CTSS)
Drug Name Drug ID Indication ICD 11 Highest Status REF
RG7625 DMDGPKS Autoimmune disease 4A40-4A45 Phase 2 [8]
SAR-114137 DMZ1XR5 Pain MG30-MG3Z Phase 1 [3]
VBY- 891 DMTKPH4 Autoimmune diabetes 5A10 Phase 1 [9]
VBY- 036 DMULRYC Neuropathic pain 8E43.0 Phase 1 [10]
VBY-129 DM4YIWK Autoimmune diabetes 5A10 Phase 1 [11]
PMID27998201-Compound-5 DMVZ0ND Chronic obstructive pulmonary disease CA22 Patented [1]
PMID27998201-Compound-9 DM1JOZN Rheumatoid arthritis FA20 Patented [1]
PMID25399719-Compound-17 DMRXKJZ N. A. N. A. Patented [5]
PMID27998201-Compound-17 DMAZVHJ Hair loss ED70 Patented [1]
Phenylalanine derivative 1 DMVYP8K Glioma 2A00.0 Patented [1]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Targeting Cathepsin F (CTSF)
Drug Name Drug ID Indication ICD 11 Highest Status REF
PMID27998201-Compound-5 DMVZ0ND Chronic obstructive pulmonary disease CA22 Patented [1]
PMID22686657C(R)-26 DM19D7G Discovery agent N.A. Investigative [12]
WRR-99 DM8ZA6K Discovery agent N.A. Investigative [13]
Benzoyl-Arginine-Alanine-Methyl Ketone DMC7TNF Discovery agent N.A. Investigative [13]
WRR-112 DMP761U Discovery agent N.A. Investigative [13]
HOMOPHENYLALANINYLMETHANE DMVBTHA Discovery agent N.A. Investigative [14]
BENZOYL-TYROSINE-ALANINE-METHYL KETONE DMIRD8S Discovery agent N.A. Investigative [14]
⏷ Show the Full List of 7 Drug(s)
Drug(s) Targeting Cathepsin V (CTSV)
Drug Name Drug ID Indication ICD 11 Highest Status REF
PMID21277783C7 DMYBV8Q Discovery agent N.A. Investigative [15]

Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Cathepsin B (CTSB) TTF2LRI CATB_HUMAN Inhibitor [1]
Cathepsin F (CTSF) TTJOKD1 CATF_HUMAN Inhibitor [1]
Cathepsin K (CTSK) TTDZN01 CATK_HUMAN Inhibitor [1]
Cathepsin L (CTSL) TT36ETB CATL1_HUMAN Inhibitor [1]
Cathepsin S (CTSS) TTUMQVO CATS_HUMAN Inhibitor [1]
Cathepsin V (CTSV) TTSD9T1 CATL2_HUMAN Inhibitor [1]

References

1 Cathepsin B and L inhibitors: a patent review (2010 - present).Expert Opin Ther Pat. 2017 Jun;27(6):643-656.
2 A novel c-Met inhibitor, MK8033, synergizes with carboplatin plus paclitaxel to inhibit ovarian cancer cell growth. Oncol Rep. 2013 May;29(5):2011-8.
3 From laboratory to pilot plant: the solid-state process development of a highly potent cathepsin S/K inhibitor. Eur J Pharm Biopharm. 2013 Apr;83(3):436-48.
4 Discovery and parallel synthesis of a new class of cathepsin K inhibitors. Bioorg Med Chem Lett. 2001 Nov 19;11(22):2951-4.
5 An updated patent review of calpain inhibitors (2012 - 2014).Expert Opin Ther Pat. 2015 Jan;25(1):17-31.
6 Functionalized benzophenone, thiophene, pyridine, and fluorene thiosemicarbazone derivatives as inhibitors of cathepsin L. Bioorg Med Chem Lett. 2010 Nov 15;20(22):6610-5.
7 Lysosomotropism of basic cathepsin K inhibitors contributes to increased cellular potencies against off-target cathepsins and reduced functional se... J Med Chem. 2005 Dec 1;48(24):7535-43.
8 Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
9 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 2353).
10 Clinical pipeline report, company report or official report of ViroBay.
11 Clinical pipeline report, company report or official report of ViroBay.
12 Selective nitrile inhibitors to modulate the proteolytic synergism of cathepsins S and F. J Med Chem. 2012 Jun 28;55(12):5982-6.
13 How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6.
14 The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42.
15 Acridone alkaloids as potent inhibitors of cathepsin V. Bioorg Med Chem. 2011 Feb 15;19(4):1477-81.