Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DM8U4HE)

Drug Name

IATX-FVIII Drug Info

Synonyms

ATX-F8 program (hemophilia A); Factor VIII inhibitor apitope (hemophilia A), Apitope; ATX-F8 program (hemophilia A), Apitope Technology

Indication

Disease Entry	ICD 11	Status	REF
Factor VIII deficiency	3B10	Investigative	[1]

Cross-matching ID

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Approved Drug(s)

Clinical Trial Drug(s)

Download the Complete Related Drug List

Drug(s) Targeting Coagulation factor VIII (F8)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Drotrecogin alfa	DM59JCN	Cerebrovascular ischaemia	8B1Z	Approved	[2]
Factor 8	DMAB6PM	Hemophilia	3B10.0	Approved	[1]
Eloctate	DMRCX8K	Haemophilia A	3B10.0	Approved	[3]
Efanesoctocog alfa	DM2CKIJ	Haemophilia A	3B10.0	Approved	[4]
SK-NBP601	DMUY09W	Hemophilia	3B10.0	Preregistration	[5]
Recombinant von Willebrand factor/recombinant Factor VIII complex	DM7JFDO	Von willebrand disease	3B12	Phase 3	[6]
N8-GP	DMY60DT	Factor VIII deficiency	3B10	Phase 3	[7]
OBI-1	DMENDP6	Factor VIII deficiency	3B10	Phase 3	[8]
BAY 94-9027	DM09M3H	Hemophilia	3B10.0	Phase 3	[9]
Plasma derived factor VIII PEGylated liposomal	DM1RWMY	Factor VIII deficiency	3B10	Phase 3	[1]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

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Drug Therapeutic Target (DTT)

References

1	URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 2607).
2	Protein C in critical illness. Am J Health Syst Pharm. 2009 Jun 15;66(12):1089-96.
3	2014 FDA drug approvals. Nat Rev Drug Discov. 2015 Feb;14(2):77-81.
4	Efanesoctocog alfa for hemophilia A: results from a phase 1 repeat-dose study. Blood Adv. 2022 Feb 22;6(4):1089-1094.
5	Clinical pipeline report, company report or official report of SK Chemicals.
6	6 Factor VIII Concentrates, Factor VIII/von Willebrand Factor Concentrates, Factor IX Concentrates, Activated Prothrombin Complex Concentrates. Transfus Med Hemother. 2009 December; 36(6): 409-418.
7	Enhancing the pharmacokinetic properties of recombinant factor VIII: first-in-human trial of glycoPEGylated recombinant factor VIII in patients with hemophilia A. J Thromb Haemost. 2013 Apr;11(4):670-8.
8	Efficacy and safety of OBI-1, an antihaemophilic factor VIII (recombinant), porcine sequence, in subjects with acquired haemophilia A. Haemophilia. 2015 Mar;21(2):162-70.
9	Phase I study of BAY 94-9027, a PEGylated B-domain-deleted recombinant factor VIII with an extended half-life, in subjects with hemophilia A. J Thromb Haemost. 2014 Apr;12(4):488-96.