Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DM8ZA6K)

Drug Name
WRR-99 Drug Info
Synonyms
WRR-99; N-[3-CARBOXY-2-HYDROXY-PROPIONYL]-D-HOMOPHENYLALANYL-AMINO-2-METHYLBUTANE; AC1NRCYX; DB03573; (3S)-3-hydroxy-4-[[(2R)-1-(3-methylbutylamino)-1-oxo-4-phenylbutan-2-yl]amino]-4-oxobutanoic acid; (3S)-3-hydroxy-4-({(2R)-1-[(3-methylbutyl)amino]-1-oxo-4-phenylbutan-2-yl}amino)-4-oxobutanoic acid; (3S)-3-hydroxy-3-{[(1R)-1-[(3-methylbutyl)carbamoyl]-3-phenylpropyl]carbamoyl}propanoic acid
Indication
Disease Entry ICD 11 Status REF
Discovery agent N.A. Investigative [1]
Cross-matching ID
PubChem CID
5289258
TTD Drug ID
DM8ZA6K

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
Drug Status:
Approved Drug(s)
Clinical Trial Drug(s)
Discontinued Drug(s)
Investigative Drug(s)
Patented Agent(s)
Download the Complete Related Drug List
Drug(s) Targeting Trypanosoma Cruzipain (Trypano CYSP)
Drug Name Drug ID Indication ICD 11 Highest Status REF
TRICLABENDAZOLE DMPWGBR Helminth infection 1F90.0 Approved [2]
MANIDIPINE DMJPGUA N. A. N. A. Phase 3 [2]
L-755507 DMPWBNU N. A. N. A. Terminated [3]
GNF-PF-4478 DMCDU8K Discovery agent N.A. Investigative [4]
K-777 DMIFCMW Discovery agent N.A. Investigative [5]
Benzoyl-Arginine-Alanine-Methyl Ketone DMC7TNF Discovery agent N.A. Investigative [1]
Vinylsulphones DMNFVO7 Infection of P. falciparum 1F40 Investigative [6]
WRR-112 DMP761U Discovery agent N.A. Investigative [1]
1-(3-Methoxy-benzyl)-5-methyl-1H-indole-2,3-dione DM30M9H Discovery agent N.A. Investigative [7]
3-amino-5-(furan-2-yl)biphenyl-2,4-dicarbonitrile DM6Y2KW Discovery agent N.A. Investigative [3]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Targeting Cathepsin F (CTSF)
Drug Name Drug ID Indication ICD 11 Highest Status REF
PMID27998201-Compound-12 DM8QZNC Bone cancer 2B5Z Patented [8]
PMID27998201-Compound-5 DMVZ0ND Chronic obstructive pulmonary disease CA22 Patented [8]
PMID22686657C(R)-26 DM19D7G Discovery agent N.A. Investigative [9]
Benzoyl-Arginine-Alanine-Methyl Ketone DMC7TNF Discovery agent N.A. Investigative [1]
WRR-112 DMP761U Discovery agent N.A. Investigative [1]
HOMOPHENYLALANINYLMETHANE DMVBTHA Discovery agent N.A. Investigative [10]
BENZOYL-TYROSINE-ALANINE-METHYL KETONE DMIRD8S Discovery agent N.A. Investigative [10]
⏷ Show the Full List of 7 Drug(s)

Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas
Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Cathepsin F (CTSF) TTJOKD1 CATF_HUMAN Inhibitor [1]
Trypanosoma Cruzipain (Trypano CYSP) TTEAID7 CYSP_TRYCR Inhibitor [1]

References

1 How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6.
2 Colloid formation by drugs in simulated intestinal fluid. J Med Chem. 2010 May 27;53(10):4259-65.
3 Quantitative analyses of aggregation, autofluorescence, and reactivity artifacts in a screen for inhibitors of a thiol protease. J Med Chem. 2010 Jan 14;53(1):37-51.
4 Complementarity between a docking and a high-throughput screen in discovering new cruzain inhibitors. J Med Chem. 2010 Jul 8;53(13):4891-905.
5 Novel non-peptidic vinylsulfones targeting the S2 and S3 subsites of parasite cysteine proteases. Bioorg Med Chem Lett. 2009 Nov 1;19(21):6218-21.
6 Opportunities and challenges in antiparasitic drug discovery. Nat Rev Drug Discov. 2005 Sep;4(9):727-40.
7 Synthesis and evaluation of isatins and thiosemicarbazone derivatives against cruzain, falcipain-2 and rhodesain. Bioorg Med Chem Lett. 2003 Oct 20;13(20):3527-30.
8 Cathepsin B and L inhibitors: a patent review (2010 - present).Expert Opin Ther Pat. 2017 Jun;27(6):643-656.
9 Selective nitrile inhibitors to modulate the proteolytic synergism of cathepsins S and F. J Med Chem. 2012 Jun 28;55(12):5982-6.
10 The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42.