General Information of Drug (ID: DM9123M)

Drug Name
9-Aminomethyl-9H-fluorene-2,5,6-triol Drug Info
Synonyms
9-(Aminomethyl)-9H-fluorene-2,5,6-triol; CHEMBL57672; 103692-55-3; 9H-Fluorene-2,5,6-triol,9-(aminomethyl)-; 2,5,6-Tfma; 9-Aminomethyl-9H-fluorene-2,5,6-triol; AC1L3YRM; ACMC-1C8EO; 2,5,6-Trihydroxy-9H-fluorene-9-methanamine; CTK4A2322; BDBM50025202; 9H-Fluorene-2,5,6-triol, 9-(aminomethyl)-
Indication
Disease Entry ICD 11 Status REF
Discovery agent N.A. Investigative [1]
Cross-matching ID
PubChem CID
124618
CAS Number
CAS 103692-55-3
TTD Drug ID
DM9123M

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
Drug Status:
Approved Drug(s)
Clinical Trial Drug(s)
Discontinued Drug(s)
Drug(s) Targeting Dopamine D1 receptor (D1R)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Phenyltoloxamine DMKAEQW Allergy 4A80-4A85 Approved [2]
Pergolide DM14MAE Parkinson disease 8A00.0 Approved [3]
Methylergonovine DMBEX4O Spontaneous abortion JA00.0 Approved [4]
Fenoldopam DMFAOKP Hypertension BA00-BA04 Approved [5]
Zicronapine DMP8ESD Schizophrenia 6A20 Phase 3 [6]
Ecopipam DMS9R43 Cocaine addiction 6C45.2 Phase 3 [7]
DAS-431 DMM3BPL Dementia 6D80-6D86 Phase 2 [8]
Dihydrexidine DMACPQO Psychotic disorder 6A20-6A25 Phase 1/2 [9]
Lu AF28996 DMY572G Parkinson disease 8A00.0 Phase 1 [10]
BAM-1110 DMPMKUF Parkinson disease 8A00.0 Discontinued in Phase 2 [11]
⏷ Show the Full List of 10 Drug(s)

Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Dopamine D1 receptor (D1R) TTZFYLI DRD1_HUMAN Inhibitor [1]

References

1 Synthesis and dopaminergic binding of 2-aryldopamine analogues: phenethylamines, 3-benzazepines, and 9-(aminomethyl)fluorenes. J Med Chem. 1986 Oct;29(10):1904-12.
2 Dopamine/serotonin receptor ligands. 9. Oxygen-containing midsized heterocyclic ring systems and nonrigidized analogues. A step toward dopamine D5 ... J Med Chem. 2004 Aug 12;47(17):4155-8.
3 Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services.
4 Reinforcement in an in vitro analog of appetitive classical conditioning of feeding behavior in Aplysia: blockade by a dopamine antagonist. Learn Mem. 2005 May-Jun;12(3):216-20.
5 Etiology of iodinated radiocontrast nephrotoxicity and its attenuation by beraprost. Yakugaku Zasshi. 2008 Jul;128(7):1023-9.
6 Clinical pipeline report, company report or official report of Lundbeck.
7 A D1 receptor antagonist, ecopipam, for treatment of tics in Tourette syndrome.Clin Neuropharmacol.2014 Jan-Feb;37(1):26-30.
8 Adrogolide HCl (ABT-431; DAS-431), a prodrug of the dopamine D1 receptor agonist, A-86929: preclinical pharmacology and clinical data. CNS Drug Rev. 2001 Fall;7(3):305-16.
9 trans-2,3-dihydroxy-6a,7,8,12b-tetrahydro-6H-chromeno[3,4-c]isoquinoline: synthesis, resolution, and preliminary pharmacological characterization o... J Med Chem. 2006 Nov 16;49(23):6848-57.
10 Clinical pipeline report, company report or official report of Lundbeck
11 Therapeutic effects of dopamine D1/D2 receptor agonists on detrusor hyperreflexia in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-lesioned parkinso... J Pharmacol Exp Ther. 1998 Jul;286(1):228-33.