Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DM9EZM0)

Drug Name

Iptacopan Drug Info

Synonyms

LNP-023; UNII-8E05T07Z6W; 8E05T07Z6W; 1644670-37-0; 4-((2S,4S)-4-ethoxy-1-((5-methoxy-7-methyl-1H-indol-4-yl)methyl)piperidin-2-yl)benzoic acid; 4-[(2~{S},4~{S})-4-ethoxy-1-[(5-methoxy-7-methyl-1~{H}-indol-4-yl)methyl]piperidin-2-yl]benzoic acid; 4-[(2S,4S)-4-ethoxy-1-[(5-methoxy-7-methyl-1H-indol-4-yl)methyl]piperidin-2-yl]benzoic acid; Iptacopan [INN]; CHEMBL4594448; SCHEMBL16400416; GTPL10710; US9682968, Example-26a; BDBM160475; ZINC223246892; compound 41 [PMID: 32073845]; HY-127105; CS-0093107; 4-((2S,4S)-(4-ethoxy-1-((5-methoxy-7-methyl-1H-indol-4-yl)methyl)piperidin-2-yl))benzoic acid; Benzoic acid, 4-((2S,4S)-4-ethoxy-1-((5-methoxy-7-methyl-1H-indol-4-yl)methyl)-2-piperidinyl)-; JGQ

Indication

Disease Entry	ICD 11	Status	REF
Paroxysmal nocturnal haemoglobinuria	3A21.0	Approved	[1]
IgA nephropathy	MF8Y	Phase 3	[2]

Cross-matching ID

PubChem CID: 90467622
CAS Number: CAS 1644670-37-0
TTD Drug ID: DM9EZM0

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Clinical Trial Drug(s)

Discontinued Drug(s)

Investigative Drug(s)

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Drug(s) Targeting Complement factor B (CFB)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
LPN023	DM7BN5W	IgA nephropathy	MF8Y	Phase 2	[4]
RG6299	DMVJL8W	Geographic atrophy	9B75	Phase 2	[5]
SAR443809	DMSUQTW	Discovery agent	N.A.	Phase 1	[6]
CAB-2	DMQ4HUA	Coronary artery disease	BA80	Discontinued in Phase 1	[7]
TA-106	DME2PFQ	Asthma	CA23	Investigative	[8]
PMID19743866C51	DMTX0ZJ	Discovery agent	N.A.	Investigative	[9]
NM-9308	DMC89HI	Age-related macular degeneration	9B75.0	Investigative	[8]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

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Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Complement factor B (CFB)	TTA0P7K	CFAB_HUMAN	Inhibitor	[3]

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References

1	FDA Approved Drug Products from FDA Official Website. 2023. Application Number: 218276
2	ClinicalTrials.gov (NCT04578834) Study of Efficacy and Safety of LNP023 in Primary IgA Nephropathy Patients (APPLAUSE-IgAN). U.S. National Institutes of Health.
3	Discovery of 4-((2 S,4 S)-4-Ethoxy-1-((5-methoxy-7-methyl-1 H-indol-4-yl)methyl)piperidin-2-yl)benzoic Acid (LNP023), a Factor B Inhibitor Specifically Designed To Be Applicable to Treating a Diverse Array of Complement Mediated Diseases. J Med Chem. 2020 Jun 11;63(11):5697-5722.
4	Complement Inhibitors in Clinical Trials for Glomerular Diseases. Front Immunol. 2019 Sep 27;10:2166.
5	Clinical pipeline report, company report or official report of Roche
6	Clinical pipeline report, company report or official report of Sanofi
7	A soluble chimeric inhibitor of C3 and C5 convertases, complement activation blocker-2, prolongs graft survival in pig-to-rhesus monkey heart transplantation. Xenotransplantation. 2002 Mar;9(2):125-34.
8	URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 2339).
9	Structure-activity relationships for substrate-based inhibitors of human complement factor B. J Med Chem. 2009 Oct 8;52(19):6042-52.