Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DM9K3LM)

Drug Name

MPDL-3280A Drug Info

Indication

Disease Entry	ICD 11	Status	REF
Melanoma	2C30	Phase 3	[1]

Cross-matching ID

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Approved Drug(s)

Clinical Trial Drug(s)

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Drug(s) Targeting Programmed cell death 1 ligand 1 (PD-L1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Avelumab	DMSZLJR	Merkel cell carcinoma	2C34	Approved	[3]
Durvalumab	DM4PVDY	Urothelial carcinoma	2C92.0	Approved	[4]
RG-7446	DM69XMQ	Urothelial carcinoma	2C92.0	Approved	[5]
Bavencio	DMU9C8F	Merkel cell carcinoma	2C34	Approved	[6]
Atezolizumab	DMMF8U0	Non-small-cell lung cancer	2C25	Approved	[7]
Sugemalimab	DMH5YQ3	Non-small-cell lung cancer	2C25	Approved in China	[8]
KN046	DMSDBPG	Non-small-cell lung cancer	2C25.Y	Phase 3	[9]
MEDI4736	DM5X849	Solid tumour/cancer	2A00-2F9Z	Phase 3	[10]
CS1001	DMSY0NE	Non-small-cell lung cancer	2C25	Phase 3	[11]
A167	DME00MM	Nasopharyngeal carcinoma	2B6B	Phase 3	[12]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

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Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Programmed cell death 1 ligand 1 (PD-L1)	TT8ZLTI	PD1L1_HUMAN	Modulator	[2]

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References

1	URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7990).
2	Targeted immunotherapy for non-small cell lung cancer. World J Clin Oncol. 2014 May 10; 5(2): 39-47.
3	Antibody-Dependent Cellular Cytotoxicity Activity of a Novel Anti-PD-L1 Antibody Avelumab (MSB0010718C) on Human Tumor Cells. Cancer Immunol Res. 2015 Oct;3(10):1148-57.
4	Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services.
5	PD-1 as a potential target in cancer therapy. Cancer Med. 2013 October; 2(5): 662-673.
6	ClinicalTrials.gov (NCT03403777) Avelumab in Refractory Testicular Germ Cell Cancer.. U.S. National Institutes of Health.
7	Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health Human Services. 2019
8	Sugemalimab: First Approval. Drugs. 2022 Apr;82(5):593-599.
9	Clinical pipeline report, company report or official report of Alphamab Oncology.
10	National Cancer Institute Drug Dictionary (drug id 740856).
11	GEMSTONE-301: a phase III clinical trial of CS1001 as consolidation therapy in patients with locally advanced/unresectable (stage III) non-small cell lung cancer (NSCLC) who did not have disease progression after prior concurrent/sequential chemoradiotherapy. Transl Lung Cancer Res. 2020 Oct;9(5):2008-2015.
12	Clinical pipeline report, company report or official report of Klus Pharma