Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DM9X24J)

Drug Name
A-70826 Drug Info
Synonyms A-70826; AC1OCF5L; 7-[3-[[(2S)-2-[[(2S)-2-aminopentanoyl]amino]pentanoyl]amino]pyrrolidin-1-yl]-1-(2,4-difluorophenyl)-6-fluoro-4-oxo-1,8-naphthyridine-3-carboxylic acid hydrochloride
Indication
Disease Entry ICD 11 Status REF
Bacterial infection 1A00-1C4Z Terminated [1]
Cross-matching ID
PubChem CID
6918207
TTD Drug ID
DM9X24J

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
Drug Status:
Approved Drug(s)
Download the Complete Related Drug List
Drug(s) Targeting Bacterial DNA gyrase (Bact gyrase)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Grepafloxacin DMGLX0T Chronic bronchitis CA20.1 Approved [3]
Ciprofloxacin XR DM2NLS9 Acute gonococcal cervicitis Approved [4]
Levofloxacin DMS60RB Acute maxillary sinusitis Approved [4]
Gatifloxacin DMSL679 Acute gonococcal cervicitis Approved [4]
Norfloxacin DMIZ6W2 Acute gonococcal cervicitis Approved [4]
Ozenoxacin DM6KZMG Impetigo 1B72 Approved [5]
Sparfloxacin DMB4HCT Bacterial infection 1A00-1C4Z Approved [4]
Gemifloxacin DMHT34O Bacterial infection 1A00-1C4Z Approved [4]
Besifloxacin DMPHXMI Ocular inflammation 9C61.24 Approved [6]
Finafloxacin DMZEONG Urinary tract infection GC08 Approved [7]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas
Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Bacterial DNA gyrase (Bact gyrase) TTN6J5F GYRA_STAAU; GYRB_STAAU Modulator [2]

References

1 Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800001978)
2 Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800001978)
3 Grepafloxacin, a dimethyl derivative of ciprofloxacin, acts preferentially through gyrase in Streptococcus pneumoniae: role of the C-5 group in tar... Antimicrob Agents Chemother. 2002 Feb;46(2):582-5.
4 Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services.
5 In vitro and in vivo antibacterial activity of T-3912, a novel non-fluorinated topical quinolone. J Antimicrob Chemother. 2002 Mar;49(3):455-65.
6 Hughes B: 2009 FDA drug approvals. Nat Rev Drug Discov. 2010 Feb;9(2):89-92.
7 2014 FDA drug approvals. Nat Rev Drug Discov. 2015 Feb;14(2):77-81.