Details of the Drug

General Information of Drug (ID: DMSL679)

Drug Name
Gatifloxacin
Synonyms
Bonoq; GTFX; Gaity; Gatiflo; Gatilox; Gatiquin; Gatispan; Tequin; Zymar; Zymaxid; Zymer; AM 1155; CG 5501;PD 135432; PD135432; AM-1155; BMS 206584-01; BMS-206584; CG-5501; Gatiflo (TN); Gatifloxacin & Gamma Interferon; Gatifloxacin (INN); Gatifloxacin (TN); Gatifloxacin [USAN:INN]; PD-135432; Tequin (TN); Tequin in dextrose 5% in plastic container; Zymar (TN); Zymer (TN); BMS-206584-01; Gatiflo,Tequin and Zymar, Gatifloxacin; AM-1155 (*Sesquihydrate*); (+-)-1-Cyclopropyl-6-fluoro-1,4-dihydro-8-methoxy-7-(3-methyl-1-piperazinyl)-4-oxo-3-quinolinecarboxylic acid; 1-Cyclopropyl-1,4-dihydro-6-fluoro-8-methoxy-7-(3-methyl-1-piperazinyl)-4-oxo-3-quinolinecarboxylic acid; 1-Cyclopropyl-6-fluoro-1,4-dihydro-8-methoxy-7-(3-methyl-1-piperazinyl)-4-oxo-3-quinolinecarboxylic acid; 1-cyclopropyl-6-fluoro-8-methoxy-7-(3-methylpiperazin-1-yl)-4-oxo-1,4-dihydroquinoline-3-carboxylic acid; 1-cyclopropyl-6-fluoro-8-methoxy-7-(3-methylpiperazin-1-yl)-4-oxoquinoline-3-carboxylic acid
Indication
Disease Entry ICD 11 Status REF
Acute gonococcal cervicitis N.A. Approved [1]
Mycoplasma pneumoniae pneumonia N.A. Approved [1]
Respiratory tract infection CA45 Approved [2]
Staphylococcal pneumonia N.A. Approved [1]
Staphylococcus aureus infection N.A. Approved [1]
Streptococcal pneumonia N.A. Approved [1]
Pneumonia caused by chlamydia N.A. Investigative [1]
⏷ Show the Full List of Indication(s)
Therapeutic Class
Antiinfective Agents
Drug Type
Small molecular drug
Structure
3D MOL 2D MOL
#Ro5 Violations (Lipinski): 0 Molecular Weight (mw) 375.4
Logarithm of the Partition Coefficient (xlogp) -0.7
Rotatable Bond Count (rotbonds) 4
Hydrogen Bond Donor Count (hbonddonor) 2
Hydrogen Bond Acceptor Count (hbondacc) 8
ADMET Property
Bioavailability
The bioavailability of drug is 96% []
Clearance
The drug present in the plasma can be removed from the body at the rate of 2.8 mL/min/kg [3]
Half-life
The concentration or amount of drug in body reduced by one-half in 7 - 14 hours [3]
Unbound Fraction
The unbound fraction of drug in plasma is 0.8% [3]
Vd
Fluid volume that would be required to contain the amount of drug present in the body at the same concentration as in the plasma 1.7 L/kg [3]
Chemical Identifiers
Formula
C19H22FN3O4
IUPAC Name
1-cyclopropyl-6-fluoro-8-methoxy-7-(3-methylpiperazin-1-yl)-4-oxoquinoline-3-carboxylic acid
Canonical SMILES
CC1CN(CCN1)C2=C(C=C3C(=C2OC)N(C=C(C3=O)C(=O)O)C4CC4)F
InChI
InChI=1S/C19H22FN3O4/c1-10-8-22(6-5-21-10)16-14(20)7-12-15(18(16)27-2)23(11-3-4-11)9-13(17(12)24)19(25)26/h7,9-11,21H,3-6,8H2,1-2H3,(H,25,26)
InChIKey
XUBOMFCQGDBHNK-UHFFFAOYSA-N
Cross-matching ID
PubChem CID
5379
ChEBI ID
CHEBI:5280
CAS Number
112811-59-3
DrugBank ID
DB01044
TTD ID
D03CQE
VARIDT ID
DR01165
Combinatorial Drugs (CBD) Click to Jump to the Detailed CBD Information of This Drug
Repurposed Drugs (RPD) Click to Jump to the Detailed RPD Information of This Drug

Molecular Interaction Atlas of This Drug


Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Bacterial DNA gyrase (Bact gyrase) TTN6J5F GYRA_STAAU ; GYRB_STAAU Modulator [4]
Staphylococcus Topoisomerase IV (Stap-coc parC) TTIXTO3 PARC_STAAS Modulator [4]

Drug Transporter (DTP)
DTP Name DTP ID UniProt ID MOA REF
Multidrug resistance-associated protein 2 (ABCC2) DTFI42L MRP2_HUMAN Substrate [5]
Organic anion transporting polypeptide 1A2 (SLCO1A2) DTE2B1D SO1A2_HUMAN Substrate [6]
P-glycoprotein 1 (ABCB1) DTUGYRD MDR1_HUMAN Substrate [7]

Drug Off-Target (DOT)
DOT Name DOT ID UniProt ID Interaction REF
Neuroendocrine convertase 1 (PCSK1) OTPBRJ54 NEC1_HUMAN Gene/Protein Processing [8]
Pro-glucagon (GCG) OTXU08VF GLUC_HUMAN Gene/Protein Processing [8]
Molecular Interaction Atlas (MIA) Jump to Detail Molecular Interaction Atlas of This Drug

Drug-Drug Interaction (DDI) Information of This Drug

Coadministration of a Drug Treating the Disease Different from Gatifloxacin (Comorbidity)
DDI Drug Name DDI Drug ID Severity Mechanism Comorbidity REF
Ivosidenib DM8S6T7 Major Increased risk of prolong QT interval by the combination of Gatifloxacin and Ivosidenib. Acute myeloid leukaemia [2A60] [9]
Midostaurin DMI6E0R Major Increased risk of prolong QT interval by the combination of Gatifloxacin and Midostaurin. Acute myeloid leukaemia [2A60] [9]
Idarubicin DMM0XGL Major Increased risk of prolong QT interval by the combination of Gatifloxacin and Idarubicin. Acute myeloid leukaemia [2A60] [9]
Arn-509 DMT81LZ Major Increased risk of prolong QT interval by the combination of Gatifloxacin and Arn-509. Acute myeloid leukaemia [2A60] [9]
Gilteritinib DMTI0ZO Major Increased risk of prolong QT interval by the combination of Gatifloxacin and Gilteritinib. Acute myeloid leukaemia [2A60] [9]
Oliceridine DM6MDCF Major Increased risk of prolong QT interval by the combination of Gatifloxacin and Oliceridine. Acute pain [MG31] [9]
Ivabradine DM0L594 Major Increased risk of ventricular arrhythmias by the combination of Gatifloxacin and Ivabradine. Angina pectoris [BA40] [10]
Bepridil DM0RKS4 Major Increased risk of prolong QT interval by the combination of Gatifloxacin and Bepridil. Angina pectoris [BA40] [11]
Dronedarone DMA8FS5 Major Increased risk of prolong QT interval by the combination of Gatifloxacin and Dronedarone. Angina pectoris [BA40] [12]
Bedaquiline DM3906J Major Increased risk of prolong QT interval by the combination of Gatifloxacin and Bedaquiline. Antimicrobial drug resistance [MG50-MG52] [9]
Cilostazol DMZMSCT Major Increased risk of prolong QT interval by the combination of Gatifloxacin and Cilostazol. Arterial occlusive disease [BD40] [9]
Posaconazole DMUL5EW Major Increased risk of prolong QT interval by the combination of Gatifloxacin and Posaconazole. Aspergillosis [1F20] [9]
Levalbuterol DM5YBO1 Moderate Increased risk of ventricular arrhythmias by the combination of Gatifloxacin and Levalbuterol. Asthma [CA23] [13]
Pirbuterol DMI5678 Moderate Increased risk of prolong QT interval by the combination of Gatifloxacin and Pirbuterol. Asthma [CA23] [13]
Lisdexamfetamine DM6W8V5 Major Increased risk of prolong QT interval by the combination of Gatifloxacin and Lisdexamfetamine. Attention deficit hyperactivity disorder [6A05] [9]
Desipramine DMT2FDC Major Increased risk of prolong QT interval by the combination of Gatifloxacin and Desipramine. Attention deficit hyperactivity disorder [6A05] [9]
Clarithromycin DM4M1SG Major Increased risk of prolong QT interval by the combination of Gatifloxacin and Clarithromycin. Bacterial infection [1A00-1C4Z] [9]
Retigabine DMGNYIH Major Increased risk of prolong QT interval by the combination of Gatifloxacin and Retigabine. Behcet disease [4A62] [9]
Lomustine DMMWSUL Minor Decreased absorption of Gatifloxacin due to intestinal mucosa variation caused by Lomustine. Brain cancer [2A00] [14]
Eribulin DM1DX4Q Major Increased risk of prolong QT interval by the combination of Gatifloxacin and Eribulin. Breast cancer [2C60-2C6Y] [9]
Lapatinib DM3BH1Y Major Increased risk of prolong QT interval by the combination of Gatifloxacin and Lapatinib. Breast cancer [2C60-2C6Y] [9]
Thiotepa DMIZKOP Minor Decreased absorption of Gatifloxacin due to intestinal mucosa variation caused by Thiotepa. Breast cancer [2C60-2C6Y] [14]
Bosutinib DMTI8YE Major Increased risk of prolong QT interval by the combination of Gatifloxacin and Bosutinib. Breast cancer [2C60-2C6Y] [9]
PF-04449913 DMSB068 Major Increased risk of prolong QT interval by the combination of Gatifloxacin and PF-04449913. Chronic myelomonocytic leukaemia [2A40] [9]
Olodaterol DM62B78 Moderate Increased risk of prolong QT interval by the combination of Gatifloxacin and Olodaterol. Chronic obstructive pulmonary disease [CA22] [15]
Vilanterol DMF5EK1 Moderate Increased risk of ventricular arrhythmias by the combination of Gatifloxacin and Vilanterol. Chronic obstructive pulmonary disease [CA22] [13]
Indacaterol DMQJHR7 Moderate Increased risk of prolong QT interval by the combination of Gatifloxacin and Indacaterol. Chronic obstructive pulmonary disease [CA22] [15]
Arformoterol DMYM974 Moderate Increased risk of prolong QT interval by the combination of Gatifloxacin and Arformoterol. Chronic obstructive pulmonary disease [CA22] [15]
Capecitabine DMTS85L Minor Decreased absorption of Gatifloxacin due to intestinal mucosa variation caused by Capecitabine. Colorectal cancer [2B91] [14]
Isoproterenol DMK7MEY Major Increased risk of ventricular arrhythmias by the combination of Gatifloxacin and Isoproterenol. Conduction disorder [BC63] [15]
Mestranol DMG3F94 Moderate Decreased absorption of Gatifloxacin due to formation of complexes caused by Mestranol. Contraceptive management [QA21] [16]
Halothane DM80OZ5 Major Increased risk of prolong QT interval by the combination of Gatifloxacin and Halothane. Corneal disease [9A76-9A78] [9]
Sevoflurane DMC9O43 Major Increased risk of prolong QT interval by the combination of Gatifloxacin and Sevoflurane. Corneal disease [9A76-9A78] [9]
Probucol DMVZQ2M Major Increased risk of prolong QT interval by the combination of Gatifloxacin and Probucol. Coronary atherosclerosis [BA80] [9]
Pasireotide DMHM7JS Major Increased risk of prolong QT interval by the combination of Gatifloxacin and Pasireotide. Cushing syndrome [5A70] [9]
Osilodrostat DMIJC9X Major Increased risk of prolong QT interval by the combination of Gatifloxacin and Osilodrostat. Cushing syndrome [5A70] [9]
Sertraline DM0FB1J Major Increased risk of prolong QT interval by the combination of Gatifloxacin and Sertraline. Depression [6A70-6A7Z] [9]
Escitalopram DMFK9HG Major Increased risk of prolong QT interval by the combination of Gatifloxacin and Escitalopram. Depression [6A70-6A7Z] [12]
Clomipramine DMINRKW Major Increased risk of prolong QT interval by the combination of Gatifloxacin and Clomipramine. Depression [6A70-6A7Z] [9]
Doxepin DMPI98T Major Increased risk of prolong QT interval by the combination of Gatifloxacin and Doxepin. Depression [6A70-6A7Z] [9]
Tetrabenazine DMYWQ0O Major Increased risk of prolong QT interval by the combination of Gatifloxacin and Tetrabenazine. Dissociative neurological symptom disorder [6B60] [9]
Deutetrabenazine DMUPFLI Major Increased risk of prolong QT interval by the combination of Gatifloxacin and Deutetrabenazine. Dystonic disorder [8A02] [9]
Ingrezza DMVPLNC Major Increased risk of prolong QT interval by the combination of Gatifloxacin and Ingrezza. Dystonic disorder [8A02] [9]
Solifenacin DMG592Q Major Increased risk of prolong QT interval by the combination of Gatifloxacin and Solifenacin. Functional bladder disorder [GC50] [9]
Sunitinib DMCBJSR Major Increased risk of prolong QT interval by the combination of Gatifloxacin and Sunitinib. Gastrointestinal stromal tumour [2B5B] [9]
Procarbazine DMIK367 Minor Decreased absorption of Gatifloxacin due to intestinal mucosa variation caused by Procarbazine. Hodgkin lymphoma [2B30] [14]
Fostemsavir DM50ILT Major Increased risk of prolong QT interval by the combination of Gatifloxacin and Fostemsavir. Human immunodeficiency virus disease [1C60-1C62] [9]
Saquinavir DMG814N Major Increased risk of prolong QT interval by the combination of Gatifloxacin and Saquinavir. Human immunodeficiency virus disease [1C60-1C62] [17]
Lopinavir DMITQS0 Major Increased risk of prolong QT interval by the combination of Gatifloxacin and Lopinavir. Human immunodeficiency virus disease [1C60-1C62] [9]
Rilpivirine DMJ0QOW Major Increased risk of prolong QT interval by the combination of Gatifloxacin and Rilpivirine. Human immunodeficiency virus disease [1C60-1C62] [9]
Bempedoic acid DM1CI9R Major Increased risk of tendinitis/tendon rupture by the combination of Gatifloxacin and Bempedoic acid. Hyper-lipoproteinaemia [5C80] [18]
Melatonin DMKWFBT Minor Decreased metabolism of Gatifloxacin caused by Melatonin mediated inhibition of CYP450 enzyme. Insomnia [7A00-7A0Z] [19]
Iron DMAP8MV Moderate Decreased absorption of Gatifloxacin due to formation of complexes caused by Iron. Iron deficiency anaemia [3A00] [20]
Polyethylene glycol DM4I1JP Moderate Increased risk of lowers seizure threshold by the combination of Gatifloxacin and Polyethylene glycol. Irritable bowel syndrome [DD91] [12]
Phenolphthalein DM5SICT Moderate Increased risk of ventricular arrhythmias by the combination of Gatifloxacin and Phenolphthalein. Irritable bowel syndrome [DD91] [19]
Crizotinib DM4F29C Major Increased risk of prolong QT interval by the combination of Gatifloxacin and Crizotinib. Lung cancer [2C25] [21]
Ceritinib DMB920Z Major Increased risk of prolong QT interval by the combination of Gatifloxacin and Ceritinib. Lung cancer [2C25] [12]
Lurbinectedin DMEFRTZ Minor Decreased absorption of Gatifloxacin due to intestinal mucosa variation caused by Lurbinectedin. Lung cancer [2C25] [14]
Osimertinib DMRJLAT Major Increased risk of prolong QT interval by the combination of Gatifloxacin and Osimertinib. Lung cancer [2C25] [9]
Selpercatinib DMZR15V Major Increased risk of prolong QT interval by the combination of Gatifloxacin and Selpercatinib. Lung cancer [2C25] [9]
Halofantrine DMOMK1V Major Increased risk of prolong QT interval by the combination of Gatifloxacin and Halofantrine. Malaria [1F40-1F45] [19]
Hydroxychloroquine DMSIVND Major Increased risk of prolong QT interval by the combination of Gatifloxacin and Hydroxychloroquine. Malaria [1F40-1F45] [9]
Primaquine DMWQ16I Major Increased risk of prolong QT interval by the combination of Gatifloxacin and Primaquine. Malaria [1F40-1F45] [9]
Inotuzumab ozogamicin DMAC130 Major Increased risk of prolong QT interval by the combination of Gatifloxacin and Inotuzumab ozogamicin. Malignant haematopoietic neoplasm [2B33] [9]
Fludarabine DMVRLT7 Minor Decreased absorption of Gatifloxacin due to intestinal mucosa variation caused by Fludarabine. Malignant haematopoietic neoplasm [2B33] [14]
Arsenic trioxide DM61TA4 Major Increased risk of prolong QT interval by the combination of Gatifloxacin and Arsenic trioxide. Mature B-cell lymphoma [2A85] [22]
Vemurafenib DM62UG5 Major Increased risk of prolong QT interval by the combination of Gatifloxacin and Vemurafenib. Melanoma [2C30] [12]
Lanthanum carbonate DMMJQSH Moderate Decreased absorption of Gatifloxacin due to formation of complexes caused by Lanthanum carbonate. Mineral absorption/transport disorder [5C64] [12]
Panobinostat DM58WKG Major Increased risk of prolong QT interval by the combination of Gatifloxacin and Panobinostat. Multiple myeloma [2A83] [23]
Melphalan flufenamide DMWF5R4 Minor Decreased absorption of Gatifloxacin due to intestinal mucosa variation caused by Melphalan flufenamide. Multiple myeloma [2A83] [14]
Siponimod DM2R86O Major Increased risk of ventricular arrhythmias by the combination of Gatifloxacin and Siponimod. Multiple sclerosis [8A40] [19]
Fingolimod DM5JVAN Major Increased risk of ventricular arrhythmias by the combination of Gatifloxacin and Fingolimod. Multiple sclerosis [8A40] [12]
Ozanimod DMT6AM2 Major Increased risk of prolong QT interval by the combination of Gatifloxacin and Ozanimod. Multiple sclerosis [8A40] [9]
Deflazacort DMV0RNS Major Increased risk of tendinitis/tendon rupture by the combination of Gatifloxacin and Deflazacort. Muscular dystrophy [8C70] [24]
Nilotinib DM7HXWT Major Increased risk of prolong QT interval by the combination of Gatifloxacin and Nilotinib. Myeloproliferative neoplasm [2A20] [12]
Dasatinib DMJV2EK Major Increased risk of prolong QT interval by the combination of Gatifloxacin and Dasatinib. Myeloproliferative neoplasm [2A20] [9]
Promethazine DM6I5GR Major Increased risk of prolong QT interval by the combination of Gatifloxacin and Promethazine. Nausea/vomiting [MD90] [9]
Bupropion DM5PCS7 Major Increased risk of lowers seizure threshold by the combination of Gatifloxacin and Bupropion. Nicotine use disorder [6C4A] [25]
Entrectinib DMMPTLH Major Increased risk of prolong QT interval by the combination of Gatifloxacin and Entrectinib. Non-small cell lung cancer [2C25] [9]
Levomethadyl Acetate DM06HG5 Major Increased risk of prolong QT interval by the combination of Gatifloxacin and Levomethadyl Acetate. Opioid use disorder [6C43] [10]
Lofexidine DM1WXA6 Major Increased risk of prolong QT interval by the combination of Gatifloxacin and Lofexidine. Opioid use disorder [6C43] [9]
Rucaparib DM9PVX8 Major Increased risk of prolong QT interval by the combination of Gatifloxacin and Rucaparib. Ovarian cancer [2C73] [9]
Ibuprofen DM8VCBE Moderate Additive CNS depression effects by the combination of Gatifloxacin and Ibuprofen. Pain [MG30-MG3Z] [26]
Triclabendazole DMPWGBR Major Increased risk of prolong QT interval by the combination of Gatifloxacin and Triclabendazole. Parasitic worm infestation [1F90] [9]
Pimavanserin DMR7IVC Major Increased risk of prolong QT interval by the combination of Gatifloxacin and Pimavanserin. Parkinsonism [8A00] [9]
Macimorelin DMQYJIR Major Increased risk of prolong QT interval by the combination of Gatifloxacin and Macimorelin. Pituitary gland disorder [5A60-5A61] [27]
Lefamulin DME6G97 Major Increased risk of prolong QT interval by the combination of Gatifloxacin and Lefamulin. Pneumonia [CA40] [27]
Choline salicylate DM8P137 Moderate Additive CNS stimulant effects by the combination of Gatifloxacin and Choline salicylate. Postoperative inflammation [1A00-CA43] [28]
Degarelix DM3O8QY Major Increased risk of prolong QT interval by the combination of Gatifloxacin and Degarelix. Prostate cancer [2C82] [9]
ABIRATERONE DM8V75C Major Increased risk of prolong QT interval by the combination of Gatifloxacin and ABIRATERONE. Prostate cancer [2C82] [9]
Enzalutamide DMGL19D Major Increased risk of prolong QT interval by the combination of Gatifloxacin and Enzalutamide. Prostate cancer [2C82] [9]
Relugolix DMK7IWL Major Increased risk of prolong QT interval by the combination of Gatifloxacin and Relugolix. Prostate cancer [2C82] [9]
Bicalutamide DMZMSPF Major Increased risk of prolong QT interval by the combination of Gatifloxacin and Bicalutamide. Prostate cancer [2C82] [9]
Levomepromazine DMIKFEL Major Increased risk of prolong QT interval by the combination of Gatifloxacin and Levomepromazine. Psychotic disorder [6A20-6A25] [9]
Salsalate DM13P4C Moderate Additive CNS stimulant effects by the combination of Gatifloxacin and Salsalate. Rheumatoid arthritis [FA20] [26]
Dexamethasone DMMWZET Major Increased risk of tendinitis/tendon rupture by the combination of Gatifloxacin and Dexamethasone. Rheumatoid arthritis [FA20] [24]
Quetiapine DM1N62C Major Increased risk of prolong QT interval by the combination of Gatifloxacin and Quetiapine. Schizophrenia [6A20] [9]
Aripiprazole DM3NUMH Moderate Increased risk of prolong QT interval by the combination of Gatifloxacin and Aripiprazole. Schizophrenia [6A20] [19]
Iloperidone DM6AUFY Major Increased risk of prolong QT interval by the combination of Gatifloxacin and Iloperidone. Schizophrenia [6A20] [12]
Paliperidone DM7NPJS Major Increased risk of prolong QT interval by the combination of Gatifloxacin and Paliperidone. Schizophrenia [6A20] [9]
Amisulpride DMSJVAM Major Increased risk of prolong QT interval by the combination of Gatifloxacin and Amisulpride. Schizophrenia [6A20] [9]
Asenapine DMSQZE2 Major Increased risk of prolong QT interval by the combination of Gatifloxacin and Asenapine. Schizophrenia [6A20] [9]
Pimozide DMW83TP Major Increased risk of prolong QT interval by the combination of Gatifloxacin and Pimozide. Schizophrenia [6A20] [10]
Ifosfamide DMCT3I8 Minor Decreased absorption of Gatifloxacin due to intestinal mucosa variation caused by Ifosfamide. Solid tumour/cancer [2A00-2F9Z] [14]
Docetaxel DMDI269 Minor Decreased absorption of Gatifloxacin due to intestinal mucosa variation caused by Docetaxel. Solid tumour/cancer [2A00-2F9Z] [14]
Mitoxantrone DMM39BF Minor Decreased absorption of Gatifloxacin due to intestinal mucosa variation caused by Mitoxantrone. Solid tumour/cancer [2A00-2F9Z] [14]
LEE011 DMMX75K Major Increased risk of prolong QT interval by the combination of Gatifloxacin and LEE011. Solid tumour/cancer [2A00-2F9Z] [9]
Vandetanib DMRICNP Major Increased risk of prolong QT interval by the combination of Gatifloxacin and Vandetanib. Solid tumour/cancer [2A00-2F9Z] [12]
Triptorelin DMTK4LS Major Increased risk of prolong QT interval by the combination of Gatifloxacin and Triptorelin. Solid tumour/cancer [2A00-2F9Z] [9]
Taxol DMUOT9V Minor Decreased absorption of Gatifloxacin due to intestinal mucosa variation caused by Taxol. Solid tumour/cancer [2A00-2F9Z] [14]
Pitolisant DM8RFNJ Major Increased risk of prolong QT interval by the combination of Gatifloxacin and Pitolisant. Somnolence [MG42] [9]
Telavancin DM58VQX Major Increased risk of prolong QT interval by the combination of Gatifloxacin and Telavancin. Staphylococcal/streptococcal disease [1B5Y] [9]
Plicamycin DM7C8YV Minor Decreased absorption of Gatifloxacin due to intestinal mucosa variation caused by Plicamycin. Testicular cancer [2C80] [14]
Lenvatinib DMB1IU4 Major Increased risk of prolong QT interval by the combination of Gatifloxacin and Lenvatinib. Thyroid cancer [2D10] [9]
Cabozantinib DMIYDT4 Major Increased risk of prolong QT interval by the combination of Gatifloxacin and Cabozantinib. Thyroid cancer [2D10] [9]
Papaverine DMCA9QP Major Increased risk of prolong QT interval by the combination of Gatifloxacin and Papaverine. Tonus and reflex abnormality [MB47] [29]
Trimeprazine DMEMV9D Major Increased risk of prolong QT interval by the combination of Gatifloxacin and Trimeprazine. Vasomotor/allergic rhinitis [CA08] [9]
Propafenone DMPIBJK Major Increased risk of prolong QT interval by the combination of Gatifloxacin and Propafenone. Ventricular tachyarrhythmia [BC71] [9]
Flecainide DMSQDLE Major Increased risk of prolong QT interval by the combination of Gatifloxacin and Flecainide. Ventricular tachyarrhythmia [BC71] [9]
Amiodarone DMUTEX3 Major Increased risk of prolong QT interval by the combination of Gatifloxacin and Amiodarone. Ventricular tachyarrhythmia [BC71] [9]
⏷ Show the Full List of 120 DDI Information of This Drug

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