General Information of Drug (ID: DMA6LR3)

Drug Name
OV101 Drug Info
Synonyms Gaboxadol
Indication
Disease Entry ICD 11 Status REF
Angelman syndrome LD90.0 Phase 3 [1]
Fragile X syndrome LD55 Phase 2 [2]
Cross-matching ID
TTD Drug ID
DMA6LR3

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
Drug Status:
Clinical Trial Drug(s)
Drug(s) Targeting GABA(A) receptor (GABAR)
Drug Name Drug ID Indication ICD 11 Highest Status REF
PH94B NS DMDC7OH Social anxiety disorder 6B04 Phase 3 [4]
Padsevonil DMRZ1F2 Epilepsy 8A60-8A68 Phase 2/3 [5]
BTD-001 DMS6ZA0 Narcolepsy 7A20 Phase 2 [6]
SAGE-324 DM5NC39 Essential tremor or related tremors 8A04.1 Phase 2 [7]
Evt201 DM8QXEY Sleep-wake disorder 7A00-7B2Z Phase 2 [8]

Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
GABA(A) receptor (GABAR) TTCI43M NOUNIPROTAC Agonist [3]

References

1 ClinicalTrials.gov (NCT03882918) An Open-Label Study to Evaluate the Long-Term Safety, Tolerability, and Efficacy of OV101 in Individuals With Angelman Syndrome. U.S.National Institutes of Health.
2 ClinicalTrials.gov (NCT03697161) A Phase 2, Randomized, Double-Blind, Parallel-Group Study Evaluating the Safety, Tolerability, and Efficacy of OV101 in Fragile X Syndrome. U.S.National Institutes of Health.
3 Gaboxadol in Fragile X Syndrome: A 12-Week Randomized, Double-Blind, Parallel-Group, Phase 2a Study. Front Pharmacol. 2021 Oct 8;12:757825.
4 Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
5 Pharmacological Profile of the Novel Antiepileptic Drug Candidate Padsevonil: Characterization in Rodent Seizure and Epilepsy Models. J Pharmacol Exp Ther. 2020 Jan;372(1):11-20.
6 Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
7 Antibodies and venom peptides: new modalities for ion channels. Nat Rev Drug Discov. 2019 May;18(5):339-357.
8 The partial positive allosteric GABA(A) receptor modulator EVT 201 is efficacious and safe in the treatment of adult primary insomnia patients. Sleep Med. 2009 Sep;10(8):859-64.