Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMAIOQB)

Drug Name

RQ-00203066 Drug Info

Synonyms

Nav1.3 antagonists (pain), RaQualia

Indication

Disease Entry	ICD 11	Status	REF
Pain	MG30-MG3Z	Investigative	[1]

Cross-matching ID

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Approved Drug(s)

Patented Agent(s)

Discontinued Drug(s)

Investigative Drug(s)

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Drug(s) Targeting Voltage-gated sodium channel alpha Nav1.3 (SCN3A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
LIDOFLAZINE	DMV23GL	Angina pectoris	BA40	Approved	[2]
Aryl carboxamide derivative 1	DMTZRCW	N. A.	N. A.	Patented	[3]
Aryl carboxamide derivative 2	DM146TA	N. A.	N. A.	Patented	[3]
Pyrimidine derivative 1	DMN9VQM	N. A.	N. A.	Patented	[3]
Pyrrolo-pyridinone derivative 6	DMXGNP8	N. A.	N. A.	Patented	[3]
Pyrrolo-pyridinone derivative 5	DMK2FSY	N. A.	N. A.	Patented	[3]
SIPATRIGINE	DMMQ4GC	Neurological disorder	6B60	Discontinued in Phase 2	[4]
U-92032	DMTYO3P	N. A.	N. A.	Terminated	[5]
PD-85639	DMNUKB4	N. A.	N. A.	Terminated	[2]
batrachotoxin	DMYH9SU	Discovery agent	N.A.	Investigative	[1]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

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Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Voltage-gated sodium channel alpha Nav1.3 (SCN3A)	TTAXZ0K	SCN3A_HUMAN	Antagonist	[1]

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References

1	URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 580).
2	Synthesis and pharmacological evaluation of phenylacetamides as sodium-channel blockers. J Med Chem. 1994 Jan 21;37(2):268-74.
3	Sodium channel blockers: a patent review (2010 - 2014).Expert Opin Ther Pat. 2015 Mar;25(3):279-90.
4	Synthesis and structure-activity relationships of 6,7-benzomorphan derivatives as use-dependent sodium channel blockers for the treatment of stroke. J Med Chem. 2002 Aug 15;45(17):3755-64.
5	Discovery of (2S)-1-(4-amino-2,3,5- trimethylphenoxy)-3-[4-[4-(4- fluorobenzyl)phenyl]-1-piperazinyl]-2-propanol dimethanesulfonate (SUN N8075): a ... J Med Chem. 2000 Sep 7;43(18):3372-6.