Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMB3LQU)

Drug Name

HuA33 Drug Info

Synonyms

CDP-833; A33-radionuclides, American Cyanamid; A33-radionuclides, Celltech; HuA33, Ludwig Institute for Cancer Research/Life Science Pharmaceuticals

Indication

Disease Entry	ICD 11	Status	REF
Colorectal cancer	2B91.Z	Phase 1	[1]

Cross-matching ID

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Clinical Trial Drug(s)

Download the Complete Related Drug List

Drug(s) Targeting Cell surface A33 antigen (GPA33)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
MGD007	DMAHWLR	Colorectal cancer	2B91.Z	Phase 1/2	[3]
KRN-330	DMA5B1S	Colorectal cancer	2B91.Z	Phase 1/2	[4]
Radiolabelled-huA33	DMIEJ0W	Colorectal cancer	2B91.Z	Phase 1	[2]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)

References

1	ClinicalTrials.gov (NCT00199797) Phase I Trial of huA33 Plus Chemotherapy in Patients With Metastatic Colorectal Cancer. U.S. National Institutes of Health.
2	(124)I-huA33 antibody PET of colorectal cancer. J Nucl Med. 2011 Aug;52(8):1173-80.
3	Bispecific antibodies rise again. Nat Rev Drug Discov. 2014 Nov;13(11):799-801.
4	Phase 1/2 study of KRN330, a fully human anti-A33 monoclonal antibody, plus irinotecan as second-line treatment for patients with metastatic colorectal cancer. Invest New Drugs. 2014 Aug;32(4):682-90.