Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMB5VQK)

Drug Name

1,4-dideoxy-1,4-imino-D-arabinito Drug Info

Synonyms

1,4-dideoxy-1,4-imino-d-arabinitol; imino-D-arabinitol; CHEMBL80254; 3,4-Pyrrolidinediol, 2-(hydroxymethyl-14C)-, (2R,3R,4R)-; (2R,3R,4R)-2-(hydroxymethyl)pyrrolidine-3,4-diol; 259140-24-4; (2R,3R,4R)-2-Hydroxymethyl-pyrrolidine-3,4-diol; BDBM50031485; AC1L9PZY; 100937-52-8; DAB-1; Lopac0_000366; MLS002153179; SCHEMBL143519; CHEMBL305131; DTXSID10180589; OQEBIHBLFRADNM-UOWFLXDJSA-N; HMS2233K17; ZINC1492250; 1,4-Dideoxy-1,4-imino-arabinitol; BDBM50016703

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

Cross-matching ID

PubChem CID: 451991
CAS Number: CAS 259140-24-4
TTD Drug ID: DMB5VQK

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Approved Drug(s)

Clinical Trial Drug(s)

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Drug(s) Targeting Intestinal maltase-glucoamylase (MGAM)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Voglibose	DMUBP9O	Diabetic complication	5A2Y	Approved	[2]
Acarbose	DMRM3AW	Diabetic complication	5A2Y	Approved	[3]
Miglitol	DMXBQAM	Diabetic complication	5A2Y	Approved	[4]
Rh-alphaglucosidase	DMNF0G8	Pompe disease	5C51.3	Approved	[5]
Deoxynojirimycin	DM2ATZB	Pompe disease	5C51.3	Phase 3	[6]
Alpha-glucosidase	DM2RTGP	Muscle disease	FB3Z	Phase 3	[7]
PAZ-320	DMU0812	Type-2 diabetes	5A11	Phase 2	[8]
SC-49483	DM180VX	Acquired immune deficiency syndrome	1C62.3	Phase 2	[9]
Maltose	DMH0ROP	N. A.	N. A.	Phase 1/2	[10]
SALACINOL	DMVKQT8	N. A.	N. A.	Phase 1/2	[11]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

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Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Intestinal maltase-glucoamylase (MGAM)	TTXWASR	MGA_HUMAN	Inhibitor	[1]

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References

1	New sugar-mimic alkaloids from the pods of Angylocalyx pynaertii. J Nat Prod. 2002 Feb;65(2):198-202.
2	Effects of changeover from voglibose to acarbose on postprandial triglycerides in type 2 diabetes mellitus patients. Adv Ther. 2009 Jun;26(6):660-6.
3	Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services.
4	Drug therapy of postprandial hyperglycaemia. Drugs. 1999 Jan;57(1):19-29.
5	2006 drug approvals: finding the niche. Nat Rev Drug Discov. 2007 Feb;6(2):99-101.
6	Nitrogen-in-the-ring pyranoses and furanoses: structural basis of inhibition of mammalian glycosidases. J Med Chem. 1994 Oct 28;37(22):3701-6.
7	URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 2627).
8	Treatment With Novel Galactomannan Derivative Reduces 2-Hour Postprandial Glucose Excursions in Individuals With Type 2 Diabetes Treated With Oral Medications and/or Insulin. J Diabetes Sci Technol. 2014 September; 8(5): 1018-1022.
9	Pathology of perbutylated-N-butyl-1-deoxynojiromycin (an alpha-glucosidase-1 inhibitor) in Sprague-Dawley rats. Toxicol Pathol. 1996 Sep-Oct;24(5):531-8.
10	DrugBank 3.0: a comprehensive resource for 'omics' research on drugs. Nucleic Acids Res. 2011 Jan;39(Database issue):D1035-41.
11	Probing the active-site requirements of human intestinal N-terminal maltase-glucoamylase: Synthesis and enzyme inhibitory activities of a six-membe... Bioorg Med Chem. 2010 Nov 15;18(22):7794-8.