Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMBF6KS)

Drug Name

TPMPA Drug Info

Synonyms

(1,2,5,6-tetrahydropyridine-4-yl)methylphosphinic acid

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

Cross-matching ID

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Investigative Drug(s)

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Drug(s) Targeting GABA(A) receptor rho3 (GABRR3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
TBPS	DMFC3XP	Discovery agent	N.A.	Investigative	[4]
isonipecotic acid	DMO1ZHE	Discovery agent	N.A.	Investigative	[4]
piperidine-4-sulphonic acid	DMMIZWE	Discovery agent	N.A.	Investigative	[4]
trans-3-ACPBPA	DM6HI8W	Discovery agent	N.A.	Investigative	[4]
cis-3-ACPBPA	DMQ0EA7	Discovery agent	N.A.	Investigative	[4]
5-Me-IAA	DMFZN7J	Discovery agent	N.A.	Investigative	[4]
aza-THIP	DML70NC	Discovery agent	N.A.	Investigative	[4]
(+/-)-cis-2-CAMP	DMY3J0B	Discovery agent	N.A.	Investigative	[4]
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Drug(s) Targeting GABA(A) receptor rho2 (GABRR2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
TBPS	DMFC3XP	Discovery agent	N.A.	Investigative	[3]
isonipecotic acid	DMO1ZHE	Discovery agent	N.A.	Investigative	[3]
piperidine-4-sulphonic acid	DMMIZWE	Discovery agent	N.A.	Investigative	[3]
trans-3-ACPBPA	DM6HI8W	Discovery agent	N.A.	Investigative	[3]
cis-3-ACPBPA	DMQ0EA7	Discovery agent	N.A.	Investigative	[3]
5-Me-IAA	DMFZN7J	Discovery agent	N.A.	Investigative	[3]
aza-THIP	DML70NC	Discovery agent	N.A.	Investigative	[3]
(+/-)-cis-2-CAMP	DMY3J0B	Discovery agent	N.A.	Investigative	[3]
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Drug(s) Targeting GABA(A) receptor rho1 (GABRR1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
TBPS	DMFC3XP	Discovery agent	N.A.	Investigative	[2]
isonipecotic acid	DMO1ZHE	Discovery agent	N.A.	Investigative	[2]
piperidine-4-sulphonic acid	DMMIZWE	Discovery agent	N.A.	Investigative	[2]
trans-3-ACPBPA	DM6HI8W	Discovery agent	N.A.	Investigative	[2]
cis-3-ACPBPA	DMQ0EA7	Discovery agent	N.A.	Investigative	[2]
5-Me-IAA	DMFZN7J	Discovery agent	N.A.	Investigative	[2]
aza-THIP	DML70NC	Discovery agent	N.A.	Investigative	[2]
(+/-)-cis-2-CAMP	DMY3J0B	Discovery agent	N.A.	Investigative	[2]
CACA	DMPKFYZ	Discovery agent	N.A.	Investigative	[5]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
GABA(A) receptor rho1 (GABRR1)	TT6XFEU	GBRR1_HUMAN	Antagonist	[2]
GABA(A) receptor rho2 (GABRR2)	TTQMXLS	GBRR2_HUMAN	Antagonist	[3]
GABA(A) receptor rho3 (GABRR3)	TT4N6D8	GBRR3_HUMAN	Antagonist	[4]

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References

1	URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 4328).
2	URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 420).
3	URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 421).
4	URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 422).
5	Characterization of bicuculline/baclofen-insensitive (rho-like) gamma-aminobutyric acid receptors expressed in Xenopus oocytes. II. Pharmacology of gamma-aminobutyric acidA and gamma-aminobutyric acidB receptor agonists and antagonists. Mol Pharmacol. 1993 Apr;43(4):609-25.