Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMBNZKH)

Drug Name

1-(2-Naphthyl)-2-aminopropane Drug Info

Synonyms

1-(naphthalen-2-yl)propan-2-amine; CHEMBL471839; 1-(2-Naphthyl)-2-aminopropane; AC1Q2BAX; SCHEMBL268036; 1-(2-naphthyl)propan-2-amine; 1-(2-Naphthyl)-2-propanamine; CTK6A7105; MolPort-004-323-272; BDBM50276189; AKOS022488613; AKOS000160972; MCULE-4757807613; NE51647; EN300-62738

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

Cross-matching ID

PubChem CID: 10219723
CAS Number: CAS 18085-03-5
TTD Drug ID: DMBNZKH

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Approved Drug(s)

Clinical Trial Drug(s)

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Drug(s) Targeting Monoamine oxidase type A (MAO-A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Moclobemide	DMNZWL7	Depression	6A70-6A7Z	Approved	[2]
Tranylcypromine	DMGB5RE	Major depressive disorder	6A70.3	Approved	[3]
Clorgyline	DMCEUJD	Parkinson disease	8A00.0	Approved	[4]
Isocarboxazid	DMAF1NB	Depression	6A70-6A7Z	Approved	[5]
TRYPTAMINE	DMAFPHB	N. A.	N. A.	Phase 3	[6]
Psoralen	DMIZJ8M	N. A.	N. A.	Phase 3	[7]
CHF-3381	DMQ2O8V	Neuropathic pain	8E43.0	Phase 2	[8]
Ladostigil	DMJSY3Q	Alzheimer disease	8A20	Phase 2	[9]
CX157	DMS2WB5	Mood disorder	6A60-6E23	Phase 2	[10]
PIPERINE	DMYEAB1	Vitiligo	ED63.0	Phase 1/2	[11]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

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Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Monoamine oxidase type A (MAO-A)	TT3WG5C	AOFA_HUMAN	Inhibitor	[1]

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References

1	Naphthylisopropylamine and N-benzylamphetamine derivatives as monoamine oxidase inhibitors. Bioorg Med Chem. 2009 Mar 15;17(6):2452-60.
2	Efficacy of citalopram and moclobemide in patients with social phobia: some preliminary findings. Hum Psychopharmacol. 2002 Dec;17(8):401-5.
3	Tramadol and another atypical opioid meperidine have exaggerated serotonin syndrome behavioural effects, but decreased analgesic effects, in genetically deficient serotonin transporter (SERT) mice. Int J Neuropsychopharmacol. 2009 Mar 11:1-11.
4	Further investigation into the mechanism of tachykinin NK(2) receptor-triggered serotonin release from guinea-pig proximal colon. J Pharmacol Sci. 2009 May;110(1):122-6.
5	MAOIs in the contemporary treatment of depression. Neuropsychopharmacology. 1995 May;12(3):185-219.
6	Binding of beta-carbolines at imidazoline I2 receptors: a structure-affinity investigation. Bioorg Med Chem Lett. 2004 Feb 23;14(4):999-1002.
7	Inhibition of rat brain monoamine oxidase activities by psoralen and isopsoralen: implications for the treatment of affective disorders. Pharmacol Toxicol. 2001 Feb;88(2):75-80.
8	Emerging drugs in neuropathic pain. Expert Opin Emerg Drugs. 2007 Mar;12(1):113-26.
9	Ladostigil: a novel multimodal neuroprotective drug with cholinesterase and brain-selective monoamine oxidase inhibitory activities for Alzheimer's disease treatment. Curr Drug Targets. 2012 Apr;13(4):483-94.
10	Reversible inhibitors of monoamine oxidase-A (RIMAs): robust, reversible inhibition of human brain MAO-A by CX157. Neuropsychopharmacology. 2010 Feb;35(3):623-31.
11	Proposed structural basis of interaction of piperine and related compounds with monoamine oxidases. Bioorg Med Chem Lett. 2010 Jan 15;20(2):537-40.