Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMBXGVH)

Drug Name

Guttiferone I Drug Info

Synonyms

Guttiferone I

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

Cross-matching ID

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Patented Agent(s)

Investigative Drug(s)

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Drug(s) Targeting Oxysterols receptor LXR-alpha (NR1H3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
US9073931, E2	DMK9FJG	N. A.	N. A.	Patented	[2]
BDBM50177019	DMEL28G	N. A.	N. A.	Patented	[3]
US9006244, E2b	DMP0TBO	N. A.	N. A.	Patented	[4]
US9073931, E1	DM2Z43I	N. A.	N. A.	Patented	[2]
US9006244, E1	DMBF1C0	N. A.	N. A.	Patented	[4]
BDBM50177012	DM52IQF	N. A.	N. A.	Patented	[3]
US9006244, E2a	DMPDF9B	N. A.	N. A.	Patented	[4]
67S	DMJL1MB	N. A.	N. A.	Patented	[3]
US9073931, E3	DMCYM8P	N. A.	N. A.	Patented	[2]
desmosterol	DMV8SUM	Discovery agent	N.A.	Investigative	[5]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

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Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Oxysterols receptor LXR-alpha (NR1H3)	TTECBXN	NR1H3_HUMAN	Inhibitor	[1]

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References

1	Guttiferone I, a new prenylated benzophenone from Garcinia humilis as a liver X receptor ligand. J Nat Prod. 2005 Apr;68(4):617-9.
2	Liver X receptor modulators. US9073931.
3	Piperazine derivatives as liver X receptor modulators. US10144715.
4	Liver X receptor modulators. US9006244.
5	Sterol intermediates from cholesterol biosynthetic pathway as liver X receptor ligands. J Biol Chem. 2006 Sep 22;281(38):27816-26.