General Information of Drug (ID: DMC64XQ)

Drug Name
PMID29130358-Compound-SB-3CT Drug Info
Cross-matching ID
TTD Drug ID
DMC64XQ

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
Drug Status:
Clinical Trial Drug(s)
Patented Agent(s)
Approved Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Curcumin DMQPH29 Solid tumour/cancer 2A00-2F9Z Phase 3 [2]
DP-b99 DM97S10 Stroke 8B20 Phase 3 [3]
GS-5745 DMP8MDW Gastric adenocarcinoma 2B72 Phase 3 [4]
Andecaliximab DMLDB1X Gastric adenocarcinoma 2B72 Phase 3 [5]
BLZ-100 DMFKA4G Glioma 2A00.0 Phase 1/2 [6]
Neovastat DMXTYWJ Non-small-cell lung cancer 2C25.Y Phase 1 [7]
PMID29130358-Compound-Figure18(14a) DMHIBTZ N. A. N. A. Patented [1]
PMID29130358-Compound-Figure17(12) DMML4PA N. A. N. A. Patented [1]
PMID29130358-Compound-Figure17(10) DMVA15O N. A. N. A. Patented [1]
PMID29130358-Compound-Figure17(11) DMSZA9L N. A. N. A. Patented [1]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Prinomastat DM9HOKG Lung cancer 2C25.0 Approved [8]
Epigallocatechin gallate DMCGWBJ Hepatic fibrosis DB93.0 Phase 3 [9]
Marimastat DM6V34C Pancreatic cancer 2C10 Phase 3 [10]
Neovastat DMXTYWJ Non-small-cell lung cancer 2C25.Y Phase 1 [7]
Metastat DMTQ4PN Acne vulgaris ED80 Phase 1 [11]
PMID29130358-Compound-Figure18(14a) DMHIBTZ N. A. N. A. Patented [1]
PMID29130358-Compound-Figure10(2a) DMFWXPS N. A. N. A. Patented [1]
PMID29130358-Compound-Figure16(9b) DMPAQLZ N. A. N. A. Patented [1]
PMID29130358-Compound-Figure16(9a) DMKX5R8 N. A. N. A. Patented [1]
PMID29130358-Compound-Figure18(14) DM7WXJ9 N. A. N. A. Patented [1]
⏷ Show the Full List of 10 Drug(s)

Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Matrix metalloproteinase-2 (MMP-2) TTLM12X MMP2_HUMAN Inhibitor [1]
Matrix metalloproteinase-9 (MMP-9) TT6X50U MMP9_HUMAN Inhibitor [1]

References

1 Gelatinase inhibitors: a patent review (2011-2017).Expert Opin Ther Pat. 2018 Jan;28(1):31-46.
2 Synthesis and biological evaluation of curcuminoid pyrazoles as new therapeutic agents in inflammatory bowel disease: effect on matrix metalloprote... Bioorg Med Chem. 2009 Feb 1;17(3):1290-6.
3 DP-b99 modulates matrix metalloproteinase activity and neuronal plasticity. PLoS One. 2014 Jun 11;9(6):e99789.
4 National Cancer Institute Drug Dictionary (drug id 747683).
5 Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
6 Antibodies and venom peptides: new modalities for ion channels. Nat Rev Drug Discov. 2019 May;18(5):339-357.
7 Neovastat, a naturally occurring multifunctional antiangiogenic drug, in phase III clinical trials. Semin Oncol. 2001 Dec;28(6):620-5.
8 AG-3340 (Agouron Pharmaceuticals Inc). IDrugs. 2000 Mar;3(3):336-45.
9 Regioselective synthesis of methylated epigallocatechin gallate via nitrobenzenesulfonyl (Ns) protecting group. Bioorg Med Chem Lett. 2009 Aug 1;19(15):4171-4.
10 Metalloelastase (MMP-12) induced inflammatory response in mice airways: effects of dexamethasone, rolipram and marimastat. Eur J Pharmacol. 2007 Mar 15;559(1):75-81.
11 Strategies for MMP inhibition in cancer: innovations for the post-trial era. Nat Rev Cancer. 2002 Sep;2(9):657-72.