General Information of Drug (ID: DMC7TNF)

Drug Name
Benzoyl-Arginine-Alanine-Methyl Ketone Drug Info
Synonyms AC1NRDMD; benzyl N-[(2S)-5-(diaminomethylamino)-1-oxo-1-(3-oxobutan-2-ylamino)pentan-2-yl]carbamate; molecular hydrogen
Indication
Disease Entry ICD 11 Status REF
Discovery agent N.A. Investigative [1]
Cross-matching ID
PubChem CID
6398520
CAS Number
CAS 1033745-37-7
TTD Drug ID
DMC7TNF

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
Drug Status:
Approved Drug(s)
Clinical Trial Drug(s)
Discontinued Drug(s)
Investigative Drug(s)
Patented Agent(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
TRICLABENDAZOLE DMPWGBR Helminth infection 1F90.0 Approved [2]
MANIDIPINE DMJPGUA N. A. N. A. Phase 3 [2]
L-755507 DMPWBNU N. A. N. A. Terminated [3]
GNF-PF-4478 DMCDU8K Discovery agent N.A. Investigative [4]
K-777 DMIFCMW Discovery agent N.A. Investigative [5]
WRR-99 DM8ZA6K Discovery agent N.A. Investigative [1]
Vinylsulphones DMNFVO7 Infection of P. falciparum 1F40 Investigative [6]
WRR-112 DMP761U Discovery agent N.A. Investigative [1]
1-(3-Methoxy-benzyl)-5-methyl-1H-indole-2,3-dione DM30M9H Discovery agent N.A. Investigative [7]
3-amino-5-(furan-2-yl)biphenyl-2,4-dicarbonitrile DM6Y2KW Discovery agent N.A. Investigative [3]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Targeting Cathepsin F (CTSF)
Drug Name Drug ID Indication ICD 11 Highest Status REF
PMID27998201-Compound-12 DM8QZNC Bone cancer 2B5Z Patented [8]
PMID27998201-Compound-5 DMVZ0ND Chronic obstructive pulmonary disease CA22 Patented [8]
PMID22686657C(R)-26 DM19D7G Discovery agent N.A. Investigative [9]
WRR-99 DM8ZA6K Discovery agent N.A. Investigative [1]
WRR-112 DMP761U Discovery agent N.A. Investigative [1]
HOMOPHENYLALANINYLMETHANE DMVBTHA Discovery agent N.A. Investigative [10]
BENZOYL-TYROSINE-ALANINE-METHYL KETONE DMIRD8S Discovery agent N.A. Investigative [10]
⏷ Show the Full List of 7 Drug(s)

Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Cathepsin F (CTSF) TTJOKD1 CATF_HUMAN Inhibitor [1]
Trypanosoma Cruzipain (Trypano CYSP) TTEAID7 CYSP_TRYCR Inhibitor [1]

References

1 How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6.
2 Colloid formation by drugs in simulated intestinal fluid. J Med Chem. 2010 May 27;53(10):4259-65.
3 Quantitative analyses of aggregation, autofluorescence, and reactivity artifacts in a screen for inhibitors of a thiol protease. J Med Chem. 2010 Jan 14;53(1):37-51.
4 Complementarity between a docking and a high-throughput screen in discovering new cruzain inhibitors. J Med Chem. 2010 Jul 8;53(13):4891-905.
5 Novel non-peptidic vinylsulfones targeting the S2 and S3 subsites of parasite cysteine proteases. Bioorg Med Chem Lett. 2009 Nov 1;19(21):6218-21.
6 Opportunities and challenges in antiparasitic drug discovery. Nat Rev Drug Discov. 2005 Sep;4(9):727-40.
7 Synthesis and evaluation of isatins and thiosemicarbazone derivatives against cruzain, falcipain-2 and rhodesain. Bioorg Med Chem Lett. 2003 Oct 20;13(20):3527-30.
8 Cathepsin B and L inhibitors: a patent review (2010 - present).Expert Opin Ther Pat. 2017 Jun;27(6):643-656.
9 Selective nitrile inhibitors to modulate the proteolytic synergism of cathepsins S and F. J Med Chem. 2012 Jun 28;55(12):5982-6.
10 The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42.