Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMC7TNF)

Drug Name

Benzoyl-Arginine-Alanine-Methyl Ketone Drug Info

Synonyms

AC1NRDMD; benzyl N-[(2S)-5-(diaminomethylamino)-1-oxo-1-(3-oxobutan-2-ylamino)pentan-2-yl]carbamate; molecular hydrogen

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

Cross-matching ID

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Approved Drug(s)

Clinical Trial Drug(s)

Discontinued Drug(s)

Investigative Drug(s)

Patented Agent(s)

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Drug(s) Targeting Trypanosoma Cruzipain (Trypano CYSP)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
TRICLABENDAZOLE	DMPWGBR	Helminth infection	1F90.0	Approved	[2]
MANIDIPINE	DMJPGUA	N. A.	N. A.	Phase 3	[2]
L-755507	DMPWBNU	N. A.	N. A.	Terminated	[3]
GNF-PF-4478	DMCDU8K	Discovery agent	N.A.	Investigative	[4]
K-777	DMIFCMW	Discovery agent	N.A.	Investigative	[5]
WRR-99	DM8ZA6K	Discovery agent	N.A.	Investigative	[1]
Vinylsulphones	DMNFVO7	Infection of P. falciparum	1F40	Investigative	[6]
WRR-112	DMP761U	Discovery agent	N.A.	Investigative	[1]
1-(3-Methoxy-benzyl)-5-methyl-1H-indole-2,3-dione	DM30M9H	Discovery agent	N.A.	Investigative	[7]
3-amino-5-(furan-2-yl)biphenyl-2,4-dicarbonitrile	DM6Y2KW	Discovery agent	N.A.	Investigative	[3]
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Drug(s) Targeting Cathepsin F (CTSF)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
PMID27998201-Compound-12	DM8QZNC	Bone cancer	2B5Z	Patented	[8]
PMID27998201-Compound-5	DMVZ0ND	Chronic obstructive pulmonary disease	CA22	Patented	[8]
PMID22686657C(R)-26	DM19D7G	Discovery agent	N.A.	Investigative	[9]
WRR-99	DM8ZA6K	Discovery agent	N.A.	Investigative	[1]
WRR-112	DMP761U	Discovery agent	N.A.	Investigative	[1]
HOMOPHENYLALANINYLMETHANE	DMVBTHA	Discovery agent	N.A.	Investigative	[10]
BENZOYL-TYROSINE-ALANINE-METHYL KETONE	DMIRD8S	Discovery agent	N.A.	Investigative	[10]
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⏷ Show the Full List of 7 Drug(s)

Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Cathepsin F (CTSF)	TTJOKD1	CATF_HUMAN	Inhibitor	[1]
Trypanosoma Cruzipain (Trypano CYSP)	TTEAID7	CYSP_TRYCR	Inhibitor	[1]

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References

1	How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6.
2	Colloid formation by drugs in simulated intestinal fluid. J Med Chem. 2010 May 27;53(10):4259-65.
3	Quantitative analyses of aggregation, autofluorescence, and reactivity artifacts in a screen for inhibitors of a thiol protease. J Med Chem. 2010 Jan 14;53(1):37-51.
4	Complementarity between a docking and a high-throughput screen in discovering new cruzain inhibitors. J Med Chem. 2010 Jul 8;53(13):4891-905.
5	Novel non-peptidic vinylsulfones targeting the S2 and S3 subsites of parasite cysteine proteases. Bioorg Med Chem Lett. 2009 Nov 1;19(21):6218-21.
6	Opportunities and challenges in antiparasitic drug discovery. Nat Rev Drug Discov. 2005 Sep;4(9):727-40.
7	Synthesis and evaluation of isatins and thiosemicarbazone derivatives against cruzain, falcipain-2 and rhodesain. Bioorg Med Chem Lett. 2003 Oct 20;13(20):3527-30.
8	Cathepsin B and L inhibitors: a patent review (2010 - present).Expert Opin Ther Pat. 2017 Jun;27(6):643-656.
9	Selective nitrile inhibitors to modulate the proteolytic synergism of cathepsins S and F. J Med Chem. 2012 Jun 28;55(12):5982-6.
10	The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42.