Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMCA0WJ)

• Drug Name: Biliverdine Ix Alpha Drug Info
• Synonyms: biliverdine; UNII-O9MIA842K9; NSC 62793; O9MIA842K9; CHEBI:17033; Biliverdin IX; 8,12-bis(2-carboxyethyl)-2,7,13,17-tetramethyl-3,18-divinylbilin-1(19)(21H,24H)-dione; Biliverdine dihydrochloride; QBUVFDKTZJNUPP-BBROENKCSA-N; Protobiliverdin IX; EINECS 204-042-2
• Cross-matching ID:
  PubChem CID: 5280353
  ChEBI ID: CHEBI:17033
  CAS Number: CAS 114-25-0
  TTD Drug ID: DMCA0WJ

Molecule-Related Drug Atlas

Drug(s) Targeting Heme oxygenase 1 (HMOX1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Stannsoporfin	DMEG4TC	Neonatal hyperbilirubinemia	KA87	Phase 2	[3]
Heme	DMGC287	Discovery agent	N.A.	Investigative	[4]
Formic Acid	DMNFZC6	Discovery agent	N.A.	Investigative	[1]
2-Propanol, Isopropanol	DML5O0H	Discovery agent	N.A.	Investigative	[1]
2-Phenylheme	DMPIQTE	Discovery agent	N.A.	Investigative	[1]
Verdoheme	DM7NRK5	Discovery agent	N.A.	Investigative	[5]
Tin protoporphyrin	DMTXJ5S	Discovery agent	N.A.	Investigative	[6]
1-(adamantan-1-yl)-2-(1H-imidazol-1-yl)ethanone	DMOTJWZ	Discovery agent	N.A.	Investigative	[4]
12-Phenylheme	DMLR2FB	Discovery agent	N.A.	Investigative	[1]

Drug(s) Affected By Interleukin-18 (IL18)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[7]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[8]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[9]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[10]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[11]
Ergotidine	DM78IME	Osteoarthritis	FA00-FA05	Approved	[12]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[13]
Propofol	DMB4OLE	Anaesthesia	9A78.6	Approved	[14]
Dihydroartemisinin	DMBXVMZ	Malaria	1F40-1F45	Approved	[15]
Sevoflurane	DMC9O43	Anaesthesia	9A78.6	Approved	[14]

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Heme oxygenase 1 (HMOX1)	TTI6V2A	HMOX1_HUMAN	Inhibitor	[1]

Drug Off-Target (DOT)

DOT Name	DOT ID	UniProt ID	Interaction	REF
Interleukin-18 (IL18)	OTBB2A8O	IL18_HUMAN	Protein Interaction/Cellular Processes	[2]

References

• [1] How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6.
• [2] Carbon monoxide donors or heme oxygenase-1 (HO-1) overexpression blocks interleukin-18-mediated NF-kappaB-PTEN-dependent human cardiac endothelial cell death. Free Radic Biol Med. 2008 Feb 1;44(3):284-98. doi: 10.1016/j.freeradbiomed.2007.08.012. Epub 2007 Aug 24.
• [3] Chemoprevention of severe neonatal hyperbilirubinemia. Semin Perinatol. 2004 Oct;28(5):365-8.
• [4] The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42.
• [5] DrugBank 3.0: a comprehensive resource for 'omics' research on drugs. Nucleic Acids Res. 2011 Jan;39(Database issue):D1035-41.
• [6] Adenovirus-mediated heme oxygenase-1 gene delivery inhibits injury-induced vascular neointima formation. Circulation. 2001 Nov 27;104(22):2710-5.
• [7] Cannabidiol Modulates the Immunophenotype and Inhibits the Activation of the Inflammasome in Human Gingival Mesenchymal Stem Cells. Front Physiol. 2016 Nov 24;7:559. doi: 10.3389/fphys.2016.00559. eCollection 2016.
• [8] Microarray analysis of H2O2-, HNE-, or tBH-treated ARPE-19 cells. Free Radic Biol Med. 2002 Nov 15;33(10):1419-32.
• [9] The contribution of methotrexate exposure and host factors on transcriptional variance in human liver. Toxicol Sci. 2007 Jun;97(2):582-94.
• [10] AS3MT facilitates NLRP3 inflammasome activation by m(6)A modification during arsenic-induced hepatic insulin resistance. Cell Biol Toxicol. 2023 Oct;39(5):2165-2181. doi: 10.1007/s10565-022-09703-7. Epub 2022 Feb 28.
• [11] Hydroquinone triggers pyroptosis and endoplasmic reticulum stress via AhR-regulated oxidative stress in human lymphocytes. Toxicol Lett. 2023 Mar 1;376:39-50. doi: 10.1016/j.toxlet.2023.01.005. Epub 2023 Jan 13.
• [12] Cimetidine induces interleukin-18 production through H2-agonist activity in monocytes. Mol Pharmacol. 2006 Aug;70(2):450-3. doi: 10.1124/mol.106.025890. Epub 2006 May 24.
• [13] Integrative "-Omics" analysis in primary human hepatocytes unravels persistent mechanisms of cyclosporine A-induced cholestasis. Chem Res Toxicol. 2016 Dec 19;29(12):2164-2174.
• [14] The differential cancer growth associated with anaesthetics in a cancer xenograft model of mice: mechanisms and implications of postoperative cancer recurrence. Cell Biol Toxicol. 2023 Aug;39(4):1561-1575. doi: 10.1007/s10565-022-09747-9. Epub 2022 Aug 12.
• [15] Dihydroartemisinin induces pyroptosis by promoting the AIM2/caspase-3/DFNA5 axis in breast cancer cells. Chem Biol Interact. 2021 May 1;340:109434. doi: 10.1016/j.cbi.2021.109434. Epub 2021 Mar 6.