Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMCJFLS)

Drug Name

MEDI-570 Drug Info

Indication

Disease Entry	ICD 11	Status	REF
Systemic lupus erythematosus	4A40.0	Phase 1	[1]

Cross-matching ID

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Clinical Trial Drug(s)

Download the Complete Related Drug List

Drug(s) Targeting Inducible T-cell costimulator (ICOS)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
JTX-2011	DMGXTOP	Solid tumour/cancer	2A00-2F9Z	Phase 2	[3]
KY1044	DMXJ683	Solid tumour/cancer	2A00-2F9Z	Phase 1/2	[4]
XmAb23104	DMK9XUQ	Solid tumour/cancer	2A00-2F9Z	Phase 1	[5]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Inducible T-cell costimulator (ICOS)	TTE5VP6	ICOS_HUMAN	Modulator	[2]

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References

1	ClinicalTrials.gov (NCT01127321) A Safety and Tolerability Study of MEDI-570 in Systemic Lupus Erythematosus. U.S. National Institutes of Health.
2	B-cell targeted therapeutics in clinical development. Arthritis Res Ther. 2013;15 Suppl 1:S4.
3	Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
4	Clinical pipeline report, company report or official report of Kymab.
5	Clinical pipeline report, company report or official report of Xencor.