Details of the Drug

General Information of Drug (ID: DMK9XUQ)

Drug Name

XmAb23104

Synonyms

XmAb104

Indication

Disease Entry	ICD 11	Status	REF
Solid tumour/cancer	2A00-2F9Z	Phase 1	[1]
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Drug Type

Antibody

Cross-matching ID

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Inducible T-cell costimulator (ICOS)	TTE5VP6	ICOS_HUMAN	Not Available	[2]
Programmed cell death protein 1 (PD-1)	TTNBFWK	PDCD1_HUMAN	Not Available	[2]

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Molecular Interaction Atlas (MIA)

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Molecular Expression Atlas of This Drug

The Studied Disease

Solid tumour/cancer

ICD Disease Classification

2A00-2F9Z

Molecule Name	Molecule Type	Gene Name	p-value	Fold-Change	Z-score
Programmed cell death protein 1 (PD-1)	DTT	PDCD1	7.26E-01	-0.01	-0.03

Molecular Expression Atlas (MEA)

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References

1	ClinicalTrials.gov (NCT03752398) A Study of XmAb23104 in Subjects With Selected Advanced Solid Tumors (DUET-3) (DUET-3). U.S. National Institutes of Health.
2	Clinical pipeline report, company report or official report of Xencor.