Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMCKZUT)

Drug Name

GlyT1 PET radiotracers Drug Info

Synonyms

GlyT1 PET radiotracers (schizophrenia); Glycine transporter 1 positron emission tomography radiotracers, Merck; [11C]-CMPyPB; Fluorine-18-CFpyPB; [18F]-MK-6577; GlyT1 PET radiotracers (schizophrenia), Merck & Co; 18F-CFpyPB

Indication

Disease Entry	ICD 11	Status	REF
Schizophrenia	6A20	Phase 1	[1]

Cross-matching ID

TTD Drug ID: DMCKZUT
VARIDT Drug ID: DR01154

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Clinical Trial Drug(s)

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Drug(s) Targeting Glycine transporter GlyT-1 (SLC6A9)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
R1678	DM4K9WH	Schizophrenia	6A20	Phase 3	[3]
BI 425809	DMH3XDR	Schizophrenia	6A20	Phase 3	[4]
Iclepertin	DM83JCK	Schizophrenia	6A20	Phase 3	[5]
AMG 747	DMWPGB8	Schizophrenia	6A20	Phase 2	[6]
ORG-25935	DMWN2EC	Psychotic disorder	6A20-6A25	Phase 2	[7]
PF-3463275	DMO02LU	Schizophrenia	6A20	Phase 2	[6]
ALX-5407	DMLJWPN	Schizophrenia	6A20	Phase 1	[8]
JNJ-17305600	DMMI4XR	Schizophrenia	6A20	Phase 1	[9]
DCCCyB	DMQ8ACY	Schizophrenia	6A20	Phase 1	[10]
MK-2637	DMUHOJP	Schizophrenia	6A20	Phase 1	[1]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

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Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Glycine transporter GlyT-1 (SLC6A9)	TTHJTF7	SC6A9_HUMAN	Modulator	[2]

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References

1	Characterization of the novel GlyT1 PET tracer [18F]MK-6577 in humans. Synapse. 2015 Jan;69(1):33-40.
2	Glycine Transport Inhibitors for the Treatment of Schizophrenia. Open Med Chem J. 2010; 4: 10-19.
3	Clinical pipeline report, company report or official report of Roche (2009).
4	Efficacy and safety of the novel glycine transporter inhibitor BI 425809 once daily in patients with schizophrenia: a double-blind, randomised, placebo-controlled phase 2 study. Lancet Psychiatry. 2021 Mar;8(3):191-201.
5	Effects of the Glycine Transporter-1 Inhibitor Iclepertin (BI 425809) on Sensory Processing, Neural Network Function, and Cognition in Animal Models Related to Schizophrenia. J Pharmacol Exp Ther. 2022 Aug;382(2):223-232.
6	Glycine transporters as novel therapeutic targets in schizophrenia, alcohol dependence and pain. Nat Rev Drug Discov. 2013 Nov;12(11):866-85.
7	The selective glycine uptake inhibitor org 25935 as an adjunctive treatment to atypical antipsychotics in predominant persistent negative symptoms of schizophrenia: results from the GIANT trial. J Clin Psychopharmacol. 2014 Apr;34(2):190-8.
8	ALX 5407: a potent, selective inhibitor of the hGlyT1 glycine transporter. Mol Pharmacol. 2001 Dec;60(6):1414-20.
9	URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 935).
10	Identification of an Orally Bioavailable, Potent, and Selective Inhibitor of GlyT1. ACS Med Chem Lett. 2010 October 14; 1(7): 350-354.