Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMCLA2D)

Drug Name

triazine compound PC10 Drug Info

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

Cross-matching ID

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Investigative Drug(s)

Patented Agent(s)

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Drug(s) Targeting Prokineticin receptor 2 (PKR2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
PKR-A	DMSJCKN	Discovery agent	N.A.	Investigative	[3]
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Drug(s) Targeting Prokineticin receptor-1 (PROKR1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
US9475795, 80	DM0ZDL3	N. A.	N. A.	Patented	[4]
ZINC19658740	DMLZDAK	N. A.	N. A.	Patented	[5]
US9475795, 89	DMR6ODL	N. A.	N. A.	Patented	[4]
US9475795, 19	DMGPDEF	N. A.	N. A.	Patented	[4]
IS1	DMNF70P	Discovery agent	N.A.	Investigative	[6]
IS20	DMQ5GA9	Discovery agent	N.A.	Investigative	[6]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

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Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Prokineticin receptor 2 (PKR2)	TTM67AX	PKR2_HUMAN	Antagonist	[2]
Prokineticin receptor-1 (PROKR1)	TTB9CIL	PKR1_HUMAN	Antagonist	[2]

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References

1	URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 6433).
2	Prokineticin receptor 1 antagonist PC-10 as a biomarker for imaging inflammatory pain. J Nucl Med. 2011 Apr;52(4):600-7.
3	Prokineticin 2 is an endangering mediator of cerebral ischemic injury. Proc Natl Acad Sci U S A. 2012 Apr 3;109(14):5475-80.
4	Sulfonyl piperidine derivatives and their use for treating prokineticin mediated diseases. US9475795.
5	Sulfonyl piperidine derivatives and their use for treating prokineticin mediated diseases. US10167273.
6	Discovery and cardioprotective effects of the first non-Peptide agonists of the G protein-coupled prokineticin receptor-1. PLoS One. 2015 Apr 1;10(4):e0121027.