Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMDO083)

Drug Name
6,7-dibromoquinoline-5,8-dione Drug Info
Synonyms
6,7-dibromoquinoline-5,8-dione; CHEMBL488961; 18633-05-1; 6,7-Dibrom-5,8-dihydrochinolin-5,8-dion; NSC82128; AC1L5TKN; SCHEMBL6866292; AC1Q6K93; 6,7-dibromo-5,8-quinolindion; CTK4D9216; DTXSID40292366; CPZKOUMVYNIHQE-UHFFFAOYSA-N; BDBM50264041; NSC-82128
Indication
Disease Entry ICD 11 Status REF
Discovery agent N.A. Investigative [1]
Cross-matching ID
PubChem CID
255964
CAS Number
CAS 18633-05-1
TTD Drug ID
DMDO083

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
Drug Status:
Clinical Trial Drug(s)
Discontinued Drug(s)
Investigative Drug(s)
Download the Complete Related Drug List
Drug(s) Targeting M-phase inducer phosphatase 2 (MPIP2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Avastin+/-Tarceva DMA86FL Non-small-cell lung cancer 2C25.Y Phase 3 [2]
MX-7065 DMP26BW Solid tumour/cancer 2A00-2F9Z Terminated [3]
2-Sulfhydryl-Ethanol DMJBO3D Discovery agent N.A. Investigative [4]
Double Oxidized Cysteine DM6TU84 Discovery agent N.A. Investigative [4]
Cysteinesulfonic Acid DMXI8FP Discovery agent N.A. Investigative [4]
Cysteine Sulfenic Acid DM4GZUJ N. A. N. A. Investigative [5]
3-isopropyl-4-(phenylthio)naphthalene-1,2-dione DMJZEMB Discovery agent N.A. Investigative [6]
4-(p-toluidino)-3-isopropylnaphthalene-1,2-dione DMQA0EJ Discovery agent N.A. Investigative [6]
ADOCIAQUINONE B DMPOU86 Discovery agent N.A. Investigative [1]
3-isopropyl-4-phenylnaphthalene-1,2-dione DMYZCWX Discovery agent N.A. Investigative [6]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas
Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
M-phase inducer phosphatase 2 (MPIP2) TTR0SWN MPIP2_HUMAN Inhibitor [1]

References

1 Novel naphthoquinone and quinolinedione inhibitors of CDC25 phosphatase activity with antiproliferative properties. Bioorg Med Chem. 2008 Oct 1;16(19):9040-9.
2 Bioactivities of simplified adociaquinone B and naphthoquinone derivatives against Cdc25B, MKP-1, and MKP-3 phosphatases. Bioorg Med Chem. 2009 Mar 15;17(6):2276-81.
3 Handbook of Assay Development in Drug Discovery, Lisa K. Minor, 2013. Page(11).
4 How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6.
5 DrugBank 3.0: a comprehensive resource for 'omics' research on drugs. Nucleic Acids Res. 2011 Jan;39(Database issue):D1035-41.
6 Synthesis of miltirone analogues as inhibitors of Cdc25 phosphatases. Bioorg Med Chem Lett. 2006 Apr 1;16(7):1905-8.