Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMDUIG3)

Drug Name

ISIS 11221 Drug Info

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

Cross-matching ID

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Discontinued Drug(s)

Investigative Drug(s)

Download the Complete Related Drug List

Drug(s) Targeting Bcl-x messenger RNA (BCL2L1 mRNA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
PURPUROGALLIN	DM63O4F	N. A.	N. A.	Terminated	[2]
TW-37	DMDE8YS	Discovery agent	N.A.	Investigative	[3]
QEDIIRNIARHLAQVGDSMDR	DMJ38YV	Discovery agent	N.A.	Investigative	[4]
4,5-dibenzylbenzene-1,2-diol	DMHURXY	Discovery agent	N.A.	Investigative	[5]
ISIS 11219	DMW3145	Discovery agent	N.A.	Investigative	[1]
ISIS 11220	DMNJS0K	Discovery agent	N.A.	Investigative	[1]
ISIS 11224	DMMGA6K	Discovery agent	N.A.	Investigative	[1]
ISIS 11223	DM7LPI4	Discovery agent	N.A.	Investigative	[1]
ISIS 16010	DMZID0W	Discovery agent	N.A.	Investigative	[1]
ISIS 16009	DMBRKFC	Discovery agent	N.A.	Investigative	[1]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

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Drug Therapeutic Target (DTT)

References

1	US patent application no. 7,148,204, Antisense modulation of bcl-x expression.
2	Discovery, characterization, and structure-activity relationships studies of proapoptotic polyphenols targeting B-cell lymphocyte/leukemia-2 proteins. J Med Chem. 2003 Sep 25;46(20):4259-64.
3	Fragment-based deconstruction of Bcl-xL inhibitors. J Med Chem. 2010 Mar 25;53(6):2577-88.
4	Structure-based design of potent small-molecule inhibitors of anti-apoptotic Bcl-2 proteins. J Med Chem. 2006 Oct 19;49(21):6139-42.
5	Vaccinia virus virulence factor N1L is a novel promising target for antiviral therapeutic intervention. J Med Chem. 2010 May 27;53(10):3899-906.