Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMDZIHT)

Drug Name

mast cell degranulating peptide Drug Info

Synonyms

MCDP; MCD peptide; Peptide 401

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

Cross-matching ID

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Investigative Drug(s)

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Drug(s) Targeting Voltage-gated potassium channel Kv1.2 (KCNA2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
[14C]TEA	DM6SFYH	Discovery agent	N.A.	Investigative	[2]
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Drug(s) Targeting Voltage-gated potassium channel Kv1.6 (KCNA6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
[14C]TEA	DM6SFYH	Discovery agent	N.A.	Investigative	[3]
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Drug(s) Targeting Voltage-gated potassium channel Kv1.1 (KCNA1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
[14C]TEA	DM6SFYH	Discovery agent	N.A.	Investigative	[2]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

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Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Voltage-gated potassium channel Kv1.1 (KCNA1)	TTS3DIK	KCNA1_HUMAN	Blocker (channel blocker)	[2]
Voltage-gated potassium channel Kv1.2 (KCNA2)	TTVFB0O	KCNA2_HUMAN	Blocker (channel blocker)	[2]
Voltage-gated potassium channel Kv1.6 (KCNA6)	TTJ2W69	KCNA6_HUMAN	Blocker (channel blocker)	[3]

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References

1	URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 2548).
2	Pharmacological characterization of five cloned voltage-gated K+ channels, types Kv1.1, 1.2, 1.3, 1.5, and 3.1, stably expressed in mammalian cell lines. Mol Pharmacol. 1994 Jun;45(6):1227-34.
3	Cloning and expression of a human voltage-gated potassium channel. A novel member of the RCK potassium channel family. EMBO J. 1990 Jun;9(6):1749-56.