General Information of Drug (ID: DME2PFQ)

Drug Name
TA-106 Drug Info
Synonyms FAb antibody fragment (inflammation), Taligen Therapeutics; Anti-factor B FAb (inflammation), Alexion
Indication
Disease Entry ICD 11 Status REF
Asthma CA23 Investigative [1]
Cross-matching ID
TTD Drug ID
DME2PFQ

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
Drug Status:
Approved Drug(s)
Clinical Trial Drug(s)
Discontinued Drug(s)
Investigative Drug(s)
Drug(s) Targeting Complement factor B (CFB)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Iptacopan DM9EZM0 Paroxysmal nocturnal haemoglobinuria 3A21.0 Approved [2]
LPN023 DM7BN5W IgA nephropathy MF8Y Phase 2 [3]
RG6299 DMVJL8W Geographic atrophy 9B75 Phase 2 [4]
SAR443809 DMSUQTW Discovery agent N.A. Phase 1 [5]
CAB-2 DMQ4HUA Coronary artery disease BA80 Discontinued in Phase 1 [6]
PMID19743866C51 DMTX0ZJ Discovery agent N.A. Investigative [7]
NM-9308 DMC89HI Age-related macular degeneration 9B75.0 Investigative [1]
⏷ Show the Full List of 7 Drug(s)

Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Complement factor B (CFB) TTA0P7K CFAB_HUMAN Not Available [1]

References

1 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 2339).
2 Discovery of 4-((2 S,4 S)-4-Ethoxy-1-((5-methoxy-7-methyl-1 H-indol-4-yl)methyl)piperidin-2-yl)benzoic Acid (LNP023), a Factor B Inhibitor Specifically Designed To Be Applicable to Treating a Diverse Array of Complement Mediated Diseases. J Med Chem. 2020 Jun 11;63(11):5697-5722.
3 Complement Inhibitors in Clinical Trials for Glomerular Diseases. Front Immunol. 2019 Sep 27;10:2166.
4 Clinical pipeline report, company report or official report of Roche
5 Clinical pipeline report, company report or official report of Sanofi
6 A soluble chimeric inhibitor of C3 and C5 convertases, complement activation blocker-2, prolongs graft survival in pig-to-rhesus monkey heart transplantation. Xenotransplantation. 2002 Mar;9(2):125-34.
7 Structure-activity relationships for substrate-based inhibitors of human complement factor B. J Med Chem. 2009 Oct 8;52(19):6042-52.