General Information of Drug (ID: DMEDSVJ)

Drug Name
Ociperlimab Drug Info
Synonyms BGB-A1217
Indication
Disease Entry ICD 11 Status REF
Non-small-cell lung cancer 2C25.Y Phase 3 [1]
Cervical cancer 2C77.0 Phase 2 [2]
Cross-matching ID
TTD Drug ID
DMEDSVJ

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
Drug Status:
Clinical Trial Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
AB154 DMUES7Y Non-small-cell lung cancer 2C25 Phase 3 [4]
GSK4428859 DMIOIU8 Aggressive cancer 2A00-2F9Z Phase 2 [5]
Rilvegostomig DMDWCM2 Non-small-cell lung cancer 2C25 Phase 1/2 [6]
ASP8374 DMA71OL Solid tumour/cancer 2A00-2F9Z Phase 1 [7]
SEA-TGT DM7GUH3 Solid tumour/cancer 2A00-2F9Z Phase 1 [8]
COM902 DMR6T8L Solid tumour/cancer 2A00-2F9Z Phase 1 [9]
M6223 DM6J085 Solid tumour/cancer 2A00-2F9Z Phase 1 [10]
⏷ Show the Full List of 7 Drug(s)

Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
V-set and immunoglobulin domain-containing protein 9 (TIGIT) TTWNL74 TIGIT_HUMAN Inhibitor [3]

References

1 ClinicalTrials.gov (NCT04746924) A Study of BGB-A1217 With Tislelizumab Compared to Pembrolizumab in Participants With Untreated Lung Cancer. U.S. National Institutes of Health.
2 ClinicalTrials.gov (NCT04693234) AdvanTIG-202: Anti-PD-1 Monoclonal Antibody Tislelizumab (BGB-A317) Combined With or Without Anti-TIGIT Monoclonal Antibody Ociperlimab (BGB-A1217) in Participants With Previously Treated Recurrent or Metastatic Cervical Cancer. U.S. National Institutes of Health.
3 Clinical pipeline report, company report or official report of BeiGene.
4 Clinical pipeline report, company report or official report of Arcus Biosciences.
5 Clinical pipeline report, company report or official report of GlaxoSmithKline
6 ClinicalTrials.gov (NCT04995523) Phase I/II, Open-label, Dose Escalation and Dose Expansion Study to Evaluate Safety, Pharmacokinetics, Pharmacodynamics and Efficacy of AZD2936 Anti-TIGIT/Anti-PD-1 Bispecific Antibody in Participants With Advanced or Metastatic NSCLC. U.S.National Institutes of Health.
7 Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
8 Clinical pipeline report, company report or official report of Seagen.
9 COM902, a novel therapeutic antibody targeting TIGIT augments anti-tumor T cell function in combination with PVRIG or PD-1 pathway blockade. Cancer Immunol Immunother. 2021 Apr 26.
10 ClinicalTrials.gov (NCT04457778) First in Human Study of M6223. U.S. National Institutes of Health.