Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMEL28G)

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Patented Agent(s)

Investigative Drug(s)

Download the Complete Related Drug List

Drug(s) Targeting Oxysterols receptor LXR-alpha (NR1H3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
US9073931, E2	DMK9FJG	N. A.	N. A.	Patented	[2]
US9006244, E2b	DMP0TBO	N. A.	N. A.	Patented	[3]
US9073931, E1	DM2Z43I	N. A.	N. A.	Patented	[2]
US9006244, E1	DMBF1C0	N. A.	N. A.	Patented	[3]
BDBM50177012	DM52IQF	N. A.	N. A.	Patented	[1]
US9006244, E2a	DMPDF9B	N. A.	N. A.	Patented	[3]
67S	DMJL1MB	N. A.	N. A.	Patented	[1]
US9073931, E3	DMCYM8P	N. A.	N. A.	Patented	[2]
desmosterol	DMV8SUM	Discovery agent	N.A.	Investigative	[4]
L-783483	DM6OTGE	Discovery agent	N.A.	Investigative	[5]
------------------------------------------------------------------------------------


⏷ Show the Full List of 10 Drug(s)

Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Oxysterols receptor LXR-alpha (NR1H3)	TTECBXN	NR1H3_HUMAN	Inhibitor	[1]

------------------------------------------------------------------------------------

References

1	Piperazine derivatives as liver X receptor modulators. US10144715.
2	Liver X receptor modulators. US9073931.
3	Liver X receptor modulators. US9006244.
4	Sterol intermediates from cholesterol biosynthetic pathway as liver X receptor ligands. J Biol Chem. 2006 Sep 22;281(38):27816-26.
5	A novel liver X receptor agonist establishes species differences in the regulation of cholesterol 7alpha-hydroxylase (CYP7a). Endocrinology. 2002 Jul;143(7):2548-58.