Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMENF5K)

Drug Name

Liatermin Drug Info

Synonyms

RGDNF; GDNF, Amgen; Glial derived neurotrophic factor, Amgen/Medtronic

Indication

Disease Entry	ICD 11	Status	REF
Lateral sclerosis	8B61	Phase 1/2	[1]

Cross-matching ID

Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Glial cell line-derived neurotrophic factor (GDNF)	TTF23ML	GDNF_HUMAN	Modulator	[2]

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References

1	ClinicalTrials.gov (NCT00111982) Trial of Extended Treatment With Liatermin (r-metHuGDNF) Administered by Continuous Intraputaminal (IPu)Infusion to Subjects With Idiopathic Parkinson's Disease Who Have Completed a Previous Trial of Liatermin. U.S. National Institutes of Health.
2	Interpreting expression profiles of cancers by genome-wide survey of breadth of expression in normal tissues. Genomics 2005 Aug;86(2):127-41.