General Information of Drug (ID: DMF3BCK)

Drug Name
PUUPEHENONE Drug Info
Synonyms
puupehenone; NSC292446; 73573-17-8; AC1Q6CTP; AC1L1JD3; CTK5D8271; NSC-292446; 10-hydroxy-4,4,6a,12b-tetramethyl-1,2,3,4,4a,5,6,6a,12a,12b-decahydro-9h-benzo[a]xanthen-9-one; 10-hydroxy-4,4,6a,12b-tetramethyl-2,3,4a,5,6,12a-hexahydro-1H-benzo[a]xanthen-9-one
Indication
Disease Entry ICD 11 Status REF
Discovery agent N.A. Investigative [1]
Cross-matching ID
PubChem CID
72536
CAS Number
CAS 73573-17-8
TTD Drug ID
DMF3BCK

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
Drug Status:
Patented Agent(s)
Discontinued Drug(s)
Investigative Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Indolizine derivative 1 DM4GZBI N. A. N. A. Patented [3]
Imidazole derivative 10 DMI7W3K N. A. N. A. Patented [4]
Indole and benzimidazole derivative 1 DMS0169 N. A. N. A. Patented [4]
Triazole derivative 3 DMZR0TH N. A. N. A. Patented [4]
Isothiazolone derivative 1 DMHAJCM N. A. N. A. Patented [4]
PMID26560362-Compound-90 DM9V13U N. A. N. A. Patented [4]
Imidazole derivative 11 DMTJ0DP N. A. N. A. Patented [4]
Tri-substituted benzene derivative 1 DMEQ3RD N. A. N. A. Patented [4]
NSC-661755 DMDJT7U N. A. N. A. Terminated [5]
KAEMPFEROL DMHEMUB Discovery agent N.A. Investigative [6]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
NSC-661755 DMDJT7U N. A. N. A. Terminated [5]
PUUPEHEDIONE DMF28IU Discovery agent N.A. Investigative [1]
MANGOSTIN DMYQGDV Discovery agent N.A. Investigative [5]
Isojaspic acid DMHTBDN Discovery agent N.A. Investigative [1]
(+)-(5S,8S,10S)-20-methoxy-9,15-ene-puupehenol DMLDQWT Discovery agent N.A. Investigative [2]
3,4,6-Tribromo-2-(2,4-dibromo-phenoxy)-phenol DMO34LJ Discovery agent N.A. Investigative [7]
NSC-292213 DMNUSKT Discovery agent N.A. Investigative [5]
Jaspic acid DMOF0TB Discovery agent N.A. Investigative [2]
DYSIDENIN DMIZQTX Discovery agent N.A. Investigative [5]
Polybrominated diphenyl ether derivative DMG7K84 Discovery agent N.A. Investigative [7]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
TEBUFELONE DMMUE8P Pain MG30-MG3Z Discontinued in Phase 2 [8]
ZD-2138 DMVFCX7 Asthma CA23 Discontinued in Phase 2 [9]
BW A4C DMNUMDG Arthritis FA20 Terminated [10]
KAEMPFEROL DMHEMUB Discovery agent N.A. Investigative [6]
2,4'-Dimethoxy-5,3'-di-(2-propenyl)-biphenyl DMWNJ84 Discovery agent N.A. Investigative [11]
METHYLHONOKIOL DM9YE6K Discovery agent N.A. Investigative [11]
HONOKIOL DMJWT3X Discovery agent N.A. Investigative [11]
PUUPEHEDIONE DMF28IU Discovery agent N.A. Investigative [1]
Isojaspic acid DMHTBDN Discovery agent N.A. Investigative [1]
5,3'-Dipropyl-biphenyl-2,4'-diol DMJRXLD Discovery agent N.A. Investigative [11]
⏷ Show the Full List of 10 Drug(s)

Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Arachidonate 12-lipoxygenase (12-LOX) TT12ABZ LOX12_HUMAN Inhibitor [2]
Arachidonate 15-lipoxygenase (15-LOX) TTN9T81 LOX15_HUMAN Inhibitor [1]
LOX-5 messenger RNA (ALOX5 mRNA) TTSJ6Q4 LOX5_HUMAN Inhibitor [1]

References

1 Using enzyme assays to evaluate the structure and bioactivity of sponge-derived meroterpenes. J Nat Prod. 2009 Oct;72(10):1857-63.
2 Exploring sponge-derived terpenoids for their potency and selectivity against 12-human, 15-human, and 15-soybean lipoxygenases. J Nat Prod. 2003 Feb;66(2):230-5.
3 Inhibitors of phospholipase A2 and their therapeutic potential: an update on patents (2012-2016).Expert Opin Ther Pat. 2017 Feb;27(2):217-225.
4 15-Lipoxygenase inhibitors: a patent review.Expert Opin Ther Pat. 2016;26(1):65-88.
5 Discovery of platelet-type 12-human lipoxygenase selective inhibitors by high-throughput screening of structurally diverse libraries. Bioorg Med Chem. 2007 Nov 15;15(22):6900-8.
6 Lipoxygenase inhibitory constituents of the fruits of noni (Morinda citrifolia) collected in Tahiti. J Nat Prod. 2007 May;70(5):859-62.
7 Probing the activity differences of simple and complex brominated aryl compounds against 15-soybean, 15-human, and 12-human lipoxygenase. J Med Chem. 2004 Jul 29;47(16):4060-5.
8 New cyclooxygenase-2/5-lipoxygenase inhibitors. 3. 7-tert-butyl-2, 3-dihydro-3,3-dimethylbenzofuran derivatives as gastrointestinal safe antiinflam... J Med Chem. 1998 Aug 27;41(18):3515-29.
9 Synthesis and biological activity of N-aroyl-tetrahydro-gamma-carbolines. Bioorg Med Chem. 2010 Jun 1;18(11):3910-24.
10 Novel and potent inhibitors of 5-lipoxygenase product synthesis based on the structure of pirinixic acid. J Med Chem. 2008 Sep 11;51(17):5449-53.
11 Design and synthesis of ten biphenyl-neolignan derivatives and their in vitro inhibitory potency against cyclooxygenase-1/2 activity and 5-lipoxyge... Bioorg Med Chem. 2009 Jul 1;17(13):4459-65.