General Information of Drug (ID: DMFUNL1)

Drug Name
Pyridoxine-5'-Phosphate Drug Info
Synonyms
Pyridoxine phosphate; Pyridoxine 5-phosphate; pyridoxine-5'-phosphate; Pyridoxyl-5-phosphate; Pyridoxol 5-phosphate; 447-05-2; Pyridoxol 5'-phosphate; UNII-RG20W8WYLS; 5-Hydroxy-4-(hydroxymethyl)-6-methyl-3-pyridylmethyl dihydrogen phosphate; PYRIDOXINE 5'-PHOSPHATE; EINECS 207-179-6; NSC 83119; RG20W8WYLS; BRN 0233737; Pyridoxol, 5-(dihydrogen phosphate); [5-hydroxy-4-(hydroxymethyl)-6-methylpyridin-3-yl]methyl dihydrogen phosphate; pyridoxine-P; pyridoxine-5P; 3,4-Pyridinedimethanol, 5-hydroxy-6-methyl-, alpha(3)-(dihydrog
Indication
Disease Entry ICD 11 Status REF
Discovery agent N.A. Investigative [1]
Cross-matching ID
PubChem CID
1055
ChEBI ID
CHEBI:28803
CAS Number
CAS 447-05-2
TTD Drug ID
DMFUNL1
INTEDE Drug ID
DR1373

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
DME
Drug Status:
Investigative Drug(s)
Approved Drug(s)
Discontinued Drug(s)
Clinical Trial Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
3-Phosphoglycerol DM9BDV2 Discovery agent N.A. Investigative [1]
1-Deoxy-D-Xylulose-5-Phosphate DMCSPU4 Discovery agent N.A. Investigative [1]
Drug Name Drug ID Indication ICD 11 Highest Status REF
Eflornithine DMJOQM3 African trypanosomiasis 1F51 Approved [3]
Putrescine DMWE6V1 Burn and burn infection ND90-NE2Z Discontinued in Phase 2 [1]
N'-Pyridoxyl-Lysine-5'-Monophosphate DM3ZHBO Discovery agent N.A. Investigative [1]
G418 DMKTJBU Discovery agent N.A. Investigative [1]
APA DMVG3K1 Discovery agent N.A. Investigative [4]
AMXT-1501 DMPSRZ0 Head and neck cancer 2D42 Investigative [5]
(2R,5R)-delta-methyl-alpha-acetylenic putrescine DMSFXEO Discovery agent N.A. Investigative [3]
ZAPOTIN DMM4ZKU Discovery agent N.A. Investigative [6]
LONCHOCARPUSONE DMWFAPJ Discovery agent N.A. Investigative [7]
Alpha-monofluoromethyl-3,4-dehydroornithine methyl ester DMGI9SM Discovery agent N.A. Investigative [3]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Pyridoxamine DMVDCGZ Diabetic kidney disease GB61.Z Phase 3 [8]

Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Bacterial Pyridoxal phosphate biosynthetic pdxJ (Bact pdxJ) TTHB48R PDXJ_ECOLI Inhibitor [1]
Ornithine decarboxylase (ODC1) TTUMGNO DCOR_HUMAN Inhibitor [1]

Drug-Metabolizing Enzyme (DME)
DME Name DME ID UniProt ID MOA REF
Pyridoxamine-phosphate oxidase (PNPO) Main DME DE3Z1RA PNPO_HUMAN Substrate [2]

References

1 How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6.
2 Pyridoxine 5'-phosphate oxidase is a novel therapeutic target and regulated by the TGF-beta signalling pathway in epithelial ovarian cancer. Cell Death Dis. 2017 Dec 13;8(12):3214.
3 Plasmodium falciparum and Plasmodium berghei: effects of ornithine decarboxylase inhibitors on erythrocytic schizogony. Exp Parasitol. 1987 Oct;64(2):237-43.
4 2-substituted 3-(aminooxy)propanamines as inhibitors of ornithine decarboxylase: synthesis and biological activity. J Med Chem. 1992 Apr 17;35(8):1339-44.
5 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1276).
6 Synthesis and cancer chemopreventive activity of zapotin, a natural product from Casimiroa edulis. J Med Chem. 2007 Jan 25;50(2):350-5.
7 New bioactive flavonoids and stilbenes in cub resin insecticide. J Nat Prod. 1999 Feb;62(2):205-10.
8 An LC-MS/MS-based method for the quantification of pyridox(am)ine 5'-phosphate oxidase activity in dried blood spots from patients with epilepsy. Anal Chem. 2017 Sep 5;89(17):8892-8900.