Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMFW5VK)

Drug Name

ISIS 100748 Drug Info

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

Cross-matching ID

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Investigative Drug(s)

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Drug(s) Targeting ADAM10 messenger RNA (ADAM10 mRNA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
ISIS 100742	DMIB6JL	Discovery agent	N.A.	Investigative	[1]
ISIS 100743	DMI7PGZ	Discovery agent	N.A.	Investigative	[1]
ISIS 100749	DMSMJ37	Discovery agent	N.A.	Investigative	[1]
PMID18068976C25	DMTZQUJ	Discovery agent	N.A.	Investigative	[2]
ISIS 100750	DMFJES5	Discovery agent	N.A.	Investigative	[1]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

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Drug Therapeutic Target (DTT)

References

1	US patent application no. 6,228,648, Antisense modulation of ADAM10 expression.
2	Conversion of an MMP-potent scaffold to an MMP-selective HER-2 sheddase inhibitor via scaffold hybridization and subtle P1' permutations. Bioorg Med Chem Lett. 2008 Jan 15;18(2):560-4.