General Information of Drug (ID: DMG9HIA)

Drug Name
Urofollitropin Drug Info
Synonyms
Bravelle; Fertinex; Metrodin; Urofollitrophin; Fertinorm HP; Bravelle (TN); Fertinex (TN); Follistim (TN); Gonal-F(TN); (4-Threonine)oxytocin; 1,2-Dithia-5,8,11,14,17-penaazacycloeicosane, cyclic peptide deriv.; 4-(L-Threonine)oxytocin
Indication
Disease Entry ICD 11 Status REF
Female infertility GA31.Z Approved [1]
Therapeutic Class
Fertility Agents
Cross-matching ID
PubChem CID
62819
TTD Drug ID
DMG9HIA
ACDINA Drug ID
D01515

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
Drug Status:
Approved Drug(s)
Clinical Trial Drug(s)
Investigative Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Menotropins DM4CF18 Female infertility GA31.Z Approved [3]
Follitropin beta DM2JTS5 Female infertility GA31.Z Approved [4]
Suramin DMTOUY9 African trypanosomiasis 1F51 Phase 1 [5]
Recombinant follicle stimulating hormone DMNHOI3 Female infertility GA31.Z Investigative [6]
PRX-111 DMSPH30 Female infertility GA31.Z Investigative [7]
Long-acting FSH conjugate DMD32IN Female infertility GA31.Z Investigative [6]
FSHR NAM DMPRMOD Contraception QA21 Investigative [6]
⏷ Show the Full List of 7 Drug(s)

Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Follicle-stimulating hormone receptor (FSHR) TTZFDBT FSHR_HUMAN Binder [2]

References

1 Natural products as sources of new drugs over the last 25 years. J Nat Prod. 2007 Mar;70(3):461-77.
2 Follicle-stimulating hormone in clinical practice: an update. Treat Endocrinol. 2004;3(3):161-71.
3 The role of gonadotropins in ovulation induction. Am J Obstet Gynecol. 1995 Feb;172(2 Pt 2):759-65.
4 Follitropin-alpha (Gonal-F) versus follitropin-beta (Puregon) in controlled ovarian hyperstimulation for in vitro fertilization: is there any diffe... Fertil Steril. 2009 Apr;91(4 Suppl):1522-5.
5 Suramin: clinical uses and structure-activity relationships. Mini Rev Med Chem. 2008 Nov;8(13):1384-94.
6 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 253).
7 A naturally occurring basically charged human follicle-stimulating hormone (FSH) variant inhibits FSH-induced androgen aromatization and tissue-type plasminogen activator enzyme activity in vitro. Neuroendocrinology. 1998 Mar;67(3):153-63.