Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMGJ0RM)

Drug Name

Pyrenemethanol Drug Info

Synonyms

4-Pyrenemethanol; (PYREN-4-YL)METHANOL; 22245-54-1; SCHEMBL975512; 4-hydroxymethylpyrene; CTK0J6579

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

Cross-matching ID

Molecule-Related Drug Atlas

Molecule Type:

DME

Drug Status:

Approved Drug(s)

Investigative Drug(s)

Clinical Trial Drug(s)

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Drug(s) Metabolized By Alcohol dehydrogenase class-I gamma (ADH1C)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[3]
Octanol	DMBGHPE	Discovery agent	N.A.	Investigative	[2]
Acetaldehyde	DMJFKG4	Discovery agent	N.A.	Investigative	[2]
Pyrene-1-aldehyde	DMEF6IP	Discovery agent	N.A.	Investigative	[2]
Hydroxymethylpyrene	DMPGAR2	Discovery agent	N.A.	Investigative	[2]
BRN-2330710	DM87VP6	Discovery agent	N.A.	Investigative	[2]
Octanal	DMTN0OK	Discovery agent	N.A.	Investigative	[2]
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Drug(s) Metabolized By Alcohol dehydrogenase class-II (ADH4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[2]
Androsterone	DMITJAK	N. A.	N. A.	Phase 3	[4]
Octanol	DMBGHPE	Discovery agent	N.A.	Investigative	[2]
Acetaldehyde	DMJFKG4	Discovery agent	N.A.	Investigative	[2]
Pyrene-1-aldehyde	DMEF6IP	Discovery agent	N.A.	Investigative	[2]
Hydroxymethylpyrene	DMPGAR2	Discovery agent	N.A.	Investigative	[2]
BRN-2330710	DM87VP6	Discovery agent	N.A.	Investigative	[2]
Octanal	DMTN0OK	Discovery agent	N.A.	Investigative	[2]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

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Drug-Metabolizing Enzyme (DME)

DME Name	DME ID	UniProt ID	MOA	REF
Alcohol dehydrogenase class-II (ADH4)	DEOCWU3	ADH4_HUMAN	Substrate	[2]
Alcohol dehydrogenase class-I gamma (ADH1C)	DEM1HNL	ADH1G_HUMAN	Substrate	[2]

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References

1	Opposing--activating or inhibitory--effects of cimetidine and daidzein on human ADH1C activity depending on substrates and solvents. Drug Metab Lett. 2012;6(4):258-64.
2	Oxidation of alcohols and reduction of aldehydes derived from methyl- and dimethylpyrenes by cDNA-expressed human alcohol dehydrogenases. Toxicology. 2008 Mar 12;245(1-2):65-75.
3	Natural alcohol exposure: is ethanol the main substrate for alcohol dehydrogenases in animals? Chem Biol Interact. 2011 May 30;191(1-3):14-25.
4	13-cis-retinoic acid competitively inhibits 3 alpha-hydroxysteroid oxidation by retinol dehydrogenase RoDH-4: a mechanism for its anti-androgenic effects in sebaceous glands? Biochem Biophys Res Commun. 2003 Mar 28;303(1):273-8.