Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMHAJ6W)

• Drug Name: 3-isopropyl-4-(phenylamino)naphthalene-1,2-dione Drug Info
• Synonyms: CHEMBL204939; 3-isopropyl-4-(phenylamino)naphthalene-1,2-dione

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

• Cross-matching ID:
  PubChem CID: 44409841
  TTD Drug ID: DMHAJ6W

Molecule-Related Drug Atlas

Drug(s) Targeting M-phase inducer phosphatase 1 (MPIP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
MX-7065	DMP26BW	Solid tumour/cancer	2A00-2F9Z	Terminated	[2]
Ro 20-1724	DM0PSCF	Asthma	CA23	Terminated	[3]
3-isopropyl-4-(phenylthio)naphthalene-1,2-dione	DMJZEMB	Discovery agent	N.A.	Investigative	[1]
4-(p-toluidino)-3-isopropylnaphthalene-1,2-dione	DMQA0EJ	Discovery agent	N.A.	Investigative	[1]
1-dodecyl-1H-indole-2,3-dione	DMK6BWV	Discovery agent	N.A.	Investigative	[4]
3-isopropyl-4-phenylnaphthalene-1,2-dione	DMYZCWX	Discovery agent	N.A.	Investigative	[1]
NSC-95397	DMX0TAM	Discovery agent	N.A.	Investigative	[5]
3-isopropylnaphthalene-1,2-dione	DM46ID2	Discovery agent	N.A.	Investigative	[1]
2-(1-dodecyl-1H-indol-3-yl)acetic acid	DMF2XHZ	Discovery agent	N.A.	Investigative	[4]
(E)-2-(1-decyl-2-oxoindolin-3-ylidene)acetic acid	DMI146O	Discovery agent	N.A.	Investigative	[4]

Drug(s) Targeting M-phase inducer phosphatase 2 (MPIP2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Avastin+/-Tarceva	DMA86FL	Non-small-cell lung cancer	2C25.Y	Phase 3	[6]
MX-7065	DMP26BW	Solid tumour/cancer	2A00-2F9Z	Terminated	[2]
2-Sulfhydryl-Ethanol	DMJBO3D	Discovery agent	N.A.	Investigative	[7]
Double Oxidized Cysteine	DM6TU84	Discovery agent	N.A.	Investigative	[7]
Cysteinesulfonic Acid	DMXI8FP	Discovery agent	N.A.	Investigative	[7]
Cysteine Sulfenic Acid	DM4GZUJ	N. A.	N. A.	Investigative	[8]
3-isopropyl-4-(phenylthio)naphthalene-1,2-dione	DMJZEMB	Discovery agent	N.A.	Investigative	[1]
4-(p-toluidino)-3-isopropylnaphthalene-1,2-dione	DMQA0EJ	Discovery agent	N.A.	Investigative	[1]
ADOCIAQUINONE B	DMPOU86	Discovery agent	N.A.	Investigative	[9]
3-isopropyl-4-phenylnaphthalene-1,2-dione	DMYZCWX	Discovery agent	N.A.	Investigative	[1]

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
M-phase inducer phosphatase 1 (MPIP1)	TTLZS4Q	MPIP1_HUMAN	Inhibitor	[1]
M-phase inducer phosphatase 2 (MPIP2)	TTR0SWN	MPIP2_HUMAN	Inhibitor	[1]

References

• [1] Synthesis of miltirone analogues as inhibitors of Cdc25 phosphatases. Bioorg Med Chem Lett. 2006 Apr 1;16(7):1905-8.
• [2] Handbook of Assay Development in Drug Discovery, Lisa K. Minor, 2013. Page(11).
• [3] Role of the Cdc25A phosphatase in human breast cancer. J Clin Invest. 2000 Sep;106(6):753-61.
• [4] Design and synthesis of N-alkyl oxindolylidene acetic acids as a new class of potent Cdc25A inhibitors. Bioorg Med Chem Lett. 2008 Jun 1;18(11):3350-3.
• [5] Structure-based de novo design and biochemical evaluation of novel Cdc25 phosphatase inhibitors. Bioorg Med Chem Lett. 2009 Aug 1;19(15):4330-4.
• [6] Bioactivities of simplified adociaquinone B and naphthoquinone derivatives against Cdc25B, MKP-1, and MKP-3 phosphatases. Bioorg Med Chem. 2009 Mar 15;17(6):2276-81.
• [7] How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6.
• [8] DrugBank 3.0: a comprehensive resource for 'omics' research on drugs. Nucleic Acids Res. 2011 Jan;39(Database issue):D1035-41.
• [9] Novel naphthoquinone and quinolinedione inhibitors of CDC25 phosphatase activity with antiproliferative properties. Bioorg Med Chem. 2008 Oct 1;16(19):9040-9.