Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMHF2OX)

Drug Name
US9409892, 19 Drug Info
Synonyms SCHEMBL15268580; CHEMBL3889830; JSYWJICQZNCWHF-UHFFFAOYSA-N; BDBM240924; US9409892, 19; 1-{[(1-Cyano-4-hydroxy-7-phenoxy-isoquinoline-3-carbonyl)-amino]-methyl}-cyclopentanecarboxylic acid
Cross-matching ID
PubChem CID
89812932
TTD Drug ID
DMHF2OX

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
Drug Status:
Clinical Trial Drug(s)
Patented Agent(s)
Download the Complete Related Drug List
Drug(s) Targeting HIF-prolyl hydroxylase 2 (HPH-2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
FG-4592 DM4XSQ2 Anaemia 3A90 Phase 3 [2]
US9422240, 1-298 DMH7DL5 N. A. N. A. Patented [3]
US8598210, Table XV, 2 DMDK98P N. A. N. A. Patented [4]
US8536181, A41 DMF9LNO N. A. N. A. Patented [5]
US8598210, Table XV, 5 DMEU5ST N. A. N. A. Patented [6]
US8536181, C17 DMRTL63 N. A. N. A. Patented [7]
US8598210, Table XV, 4 DM3XWMO N. A. N. A. Patented [8]
US8921389, 210 DME1A80 N. A. N. A. Patented [9]
US8536181, C35 DMAM51Z N. A. N. A. Patented [5]
US10100051, Compound 2 DMWESZ1 N. A. N. A. Patented [10]
⏷ Show the Full List of 10 Drug(s)

Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas
Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
HIF-prolyl hydroxylase 2 (HPH-2) TT9ISBX EGLN1_HUMAN Inhibitor [1]

References

1 4-hydroxy-isoquinoline compounds as HIF hydroxylase inhibitors. US9409892.
2 Crystalline forms of a prolyl hydroxylase inhibitor. US9115085.
3 Partially saturated nitrogen-containing heterocyclic compound. US9422240.
4 Prolyl hydroxylase inhibitors and methods of use. US9598370.
5 Prolyl hydroxylase inhibitors. US8536181.
6 Prolyl hydroxylase inhibitors and method of use. US8722895.
7 Methods for increasing the stabilization of hypoxia inducible factor-1 alpha. US8778412.
8 Prolyl hydroxylase inhibitors and methods of use. US8598210.
9 Naphthyridine derivatives as inhibitors of Hypoxia inducible factor (HIF) hydroxylase. US9695170.
10 Compound of 5-hydroxyl-1,7-naphthyridine substituted by aryloxy or heteroaryloxy, preparation method thereof and pharmaceutical use thereof. US10100051.