Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMHI0KL)

Drug Name

ION373 Drug Info

Synonyms

Zilganersen

Indication

Disease Entry	ICD 11	Status	REF
Alexander disease	8A44.2	Phase 3	[1]

Cross-matching ID

Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Glial fibrillary acidic protein messenger RNA (GFAP mRNA)	TTI6FFX	GFAP_HUMAN	Inhibitor	[2]

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References

1	ClinicalTrials.gov (NCT04849741) A Phase 1-3, Double-Blind, Randomized, Placebo-Controlled Study to Evaluate the Efficacy, Safety, Pharmacokinetics and Pharmacodynamics of Intrathecally Administered Zilganersen (ION373) in Patients With Alexander Disease. U.S.National Institutes of Health.
2	Clinical pipeline report, company report or official report of Ionis