Details of the Drug

General Information of Drug (ID: DMHI0KL)

Drug Name

ION373

Synonyms

Zilganersen

Indication

Disease Entry	ICD 11	Status	REF
Alexander disease	8A44.2	Phase 3	[1]
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Drug Type

Antisense oligonucleotide

Cross-matching ID

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Glial fibrillary acidic protein messenger RNA (GFAP mRNA)	TTI6FFX	GFAP_HUMAN	Inhibitor	[2]

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Molecular Interaction Atlas (MIA)

Jump to Detail Molecular Interaction Atlas of This Drug

References

1	ClinicalTrials.gov (NCT04849741) A Phase 1-3, Double-Blind, Randomized, Placebo-Controlled Study to Evaluate the Efficacy, Safety, Pharmacokinetics and Pharmacodynamics of Intrathecally Administered Zilganersen (ION373) in Patients With Alexander Disease. U.S.National Institutes of Health.
2	Clinical pipeline report, company report or official report of Ionis