Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMHIA7Y)

Drug Name

TAS-1440 Drug Info

Indication

Disease Entry	ICD 11	Status	REF
Acute myeloid leukaemia	2A60	Phase 1	[1]

Cross-matching ID

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Clinical Trial Drug(s)

Patented Agent(s)

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Drug(s) Targeting Lysine-specific histone demethylase 1 (LSD)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
IMG-7289	DML9AVG	Acute myeloid leukaemia	2A60	Phase 2	[3]
CC-90011	DM0EDHJ	Lymphoma	2A80-2A86	Phase 2	[3]
CC-90011	DM0EDHJ	Lymphoma	2A80-2A86	Phase 2	[4]
Vafidemstat	DM64ZGY	Alzheimer disease	8A20	Phase 2	[5]
ORY-2001	DMYM0UY	Alzheimer disease	8A20	Phase 2	[6]
INCB59872	DMRLV7G	Acute myeloid leukaemia	2A60	Phase 1/2	[3]
GSK2879552	DMT3V2W	Small-cell lung cancer	2C25.Y	Phase 1	[7]
Seclidemstat	DMCP7SD	Ewing sarcoma	2B52	Phase 1	[8]
Tarnylcypromine derivative 2	DMEJR2F	N. A.	N. A.	Patented	[9]
Tarnylcypromine derivative 3	DMKJOMC	N. A.	N. A.	Patented	[9]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

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Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Lysine-specific histone demethylase 1 (LSD)	TTNR0UQ	KDM1A_HUMAN	Inhibitor	[2]

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References

1	ClinicalTrials.gov (NCT04282668) A Study of TAS1440 With ATRA in Subjects With r/r AML. U.S. National Institutes of Health.
2	Clinical pipeline report, company report or official report of Astex Pharmaceuticals.
3	Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
4	Discovery of CC-90011: A Potent and Selective Reversible Inhibitor of Lysine Specific Demethylase 1 (LSD1). J Med Chem. 2020 Dec 10;63(23):14522-14529.
5	Efficacy of Vafidemstat in Experimental Autoimmune Encephalomyelitis Highlights the KDM1A/RCOR1/HDAC Epigenetic Axis in Multiple Sclerosis. Pharmaceutics. 2022 Jul 6;14(7):1420.
6	Clinical pipeline report, company report or official report of Oryzon Genomics Boston, MA
7	A DNA Hypomethylation Signature Predicts Antitumor Activity of LSD1 Inhibitors in SCLC. Cancer Cell. 2015 Jul 13;28(1):57-69.
8	Scaffolding LSD1 Inhibitors Impair NK Cell Metabolism and Cytotoxic Function Through Depletion of Glutathione. Front Immunol. 2020 Sep 17;11:2196.
9	LSD1 inhibitors: a patent review (2010-2015).Expert Opin Ther Pat. 2016 May;26(5):565-80.